SFRP5 as a new cardiovascular biological marker: a literature review
- Authors: Alieva A.M.1, Teplova N.V.1, Baykova I.E.1, Voronkova K.V.1, Shnakhova L.M.2, Makeeva L.M.1, Kotikova I.A.1, Nikitin I.G.1
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Affiliations:
- Pirogov Russian National Research Medical University
- Sechenov First Moscow State Medical University (Sechenov Unuiversity)
- Issue: Vol 13, No 4 (2022)
- Pages: 206-212
- Section: Reviews
- URL: https://journals.rcsi.science/2221-7185/article/view/134167
- DOI: https://doi.org/10.17816/CS139218
- ID: 134167
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Abstract
Research into new biological markers may help early diagnosis and effective therapy for cardiology patients. The use of biomarkers to evaluate patients has made a major impact in oncology, but is still in its infancy in the cardiology field. Studies on secreted frizzled-related protein 5 (SFRP5) have revealed its potential use as a marker of cardiovascular pathology. Preclinical studies have highlighted the important role this protein plays in many biological processes. It reduces the proliferation and migration of cardiac fibroblasts and suppresses the Wnt5A/JNK signaling pathway thus reducing the severity of oxidative stress and inflammation. It normalizes nitric oxide production and has several other effects. However, recent clinical studies of SFRP5 have produced conflicting data. Nevertheless, this protein shows promise as a marker for several metabolic and cardiovascular diseases. Preliminary data also suggest SFRP5 may be a therapeutic target. Further study of SFRP5 and its role in cardiovascular pathology is necessary, and will create new diagnostic and prognostic possibilities for this biological marker.
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##article.viewOnOriginalSite##About the authors
Amina M. Alieva
Pirogov Russian National Research Medical University
Author for correspondence.
Email: amisha_alieva@mail.ru
ORCID iD: 0000-0001-5416-8579
SPIN-code: 2749-6427
MD, Cand. Sci. (Med.)
Russian Federation, 1 Ostrovityanova Str., 117997, MoscowNatalia V. Teplova
Pirogov Russian National Research Medical University
Email: teplova.nv@yandex.ru
ORCID iD: 0000-0002-7181-4680
SPIN-code: 9056-1948
MD, D. Sci. (Med.)
Russian Federation, 1 Ostrovityanova Str., 117997, MoscowIrina E. Baykova
Pirogov Russian National Research Medical University
Email: 1498553@mail.ru
ORCID iD: 0000-0003-0886-6290
SPIN-code: 3054-8884
MD, Cand. Sci. (Med.)
Russian Federation, 1 Ostrovityanova Str., 117997, MoscowKira V. Voronkova
Pirogov Russian National Research Medical University
Email: kiravoronkova@yandex.ru
ORCID iD: 0000-0003-1111-6378
SPIN-code: 1636-7627
MD, D. Sci. (Med.)
Russian Federation, 1 Ostrovityanova Str., 117997, MoscowLidiya M. Shnakhova
Sechenov First Moscow State Medical University (Sechenov Unuiversity)
Email: shnakhova_l_m@staff.sechenov.ru
ORCID iD: 0000-0003-3000-0987
SPIN-code: 5549-5823
doctor consultant
Russian Federation, MoscowLyudmila M. Makeeva
Pirogov Russian National Research Medical University
Email: mila-mm@yandex.ru
ORCID iD: 0000-0003-0755-4869
Department Assist.
Russian Federation, 1 Ostrovityanova Str., 117997, MoscowIrina A. Kotikova
Pirogov Russian National Research Medical University
Email: kotikova.ia@mail.ru
ORCID iD: 0000-0001-5352-8499
SPIN-code: 1423-7300
6th year student
Russian Federation, 1 Ostrovityanova Str., 117997, MoscowIgor G. Nikitin
Pirogov Russian National Research Medical University
Email: igor.nikitin.64@mail.ru
ORCID iD: 0000-0003-1699-0881
SPIN-code: 3595-1990
MD, D. Sci. (Med.), Prof.
Russian Federation, 1 Ostrovityanova Str., 117997, MoscowReferences
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