Statins in the primary prevention of cardiovascular disease. Rosuvastatin capabilities

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Abstract

The article discusses the modern principles of lipid-lowering therapy and approaches to its administration in terms of levels of cardiovascular risk. The characteristics of groups of patients with different levels of cardiovascular risk (from low to high) in primary prevention are given. The article defines the target levels of low- density lipoprotein cholesterol, which should be achieved with the modern lipid-lowering therapy. The clinical effects of statins in primary prevention are presented. The clinical results of two large studies of rosuvastatin that have changed the approach to statin prescribing in primary prevention are discussed. The article presents the results of the analysis of long-term follow-up of patients in the primary prevention after the completion of randomized clinical studies. Approaches to the use of statins for novel coronavirus infection are considered.

About the authors

Marina G. Bubnova

National Medical Research Center for Therapy and Preventive Medicine

Author for correspondence.
Email: mbubnova@gnicpm.ru
ORCID iD: 0000-0003-2250-5942

D. Sci. (Med.), Prof., National Medical Research Center for Therapy and Preventive Medicine

Russian Federation, Moscow

Marianna Y. Ilchenko

Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia for the Samara Region

Email: ilchenko@yahoo.com
ORCID iD: 0000-0003-4319-3300

deputy head of hospital for medical work, Medical and Sanitary Unit of the Ministry of Internal Affairs of Russia for the Samara Region

Russian Federation, Samara

Petr A. Lebedev

Samara State Medical University

Email: palebedev@yahoo.com
ORCID iD: 0000-0003-1404-7099

D. Sci. (Med.), Prof., Samara State Medical University

Russian Federation, Samara

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