Hypertrophic cardiomyopathy: a modern view of the problem

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Abstract

Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, with a prevalence of approximately 1 in 500 among the adult cohort. It is a common etiological factor of sudden cardiac death in the young and a common cause of morbidity and mortality in all age groups. HCM is characterized by a complex pathophysiology, which is manifested by a heterogeneous clinical picture. The mechanism of development of this variant of hypertrophy is not fully understood. Currently, only a part of the genetic mutations that correlate with the development of this pathology has been identified. In this regard, the issue of genetic diagnosis of HCM is very relevant, as it will allow us to conduct advanced screening. A very important task is to develop a personalized approach in the conservative and surgical treatment of people suffering from this variant of cardiopathy.

About the authors

Amina M. Alieva

Pirogov Russian National Research Medical University

Author for correspondence.
Email: amisha_alieva@mail.ru

Cand. Sci. (Med.), Pirogov Russian National Research Medical University

Russian Federation, Moscow

Ilda I. Almazova

National Medical Research Center for Therapy and Preventive Medicine

Email: almazovai@rambler.ru

doctor-teacher, National Medical Research Center for Therapy and Preventive Medicine

Russian Federation, Moscow

Elena V. Reznik

Pirogov Russian National Research Medical University

Email: elenaresnik@gmail.com

D. Sci. (Med.), Prof., Pirogov Russian National Research Medical University

Russian Federation, Moscow

Tatyana V. Pinchuk

Pirogov Russian National Research Medical University

Email: doktor2000@inbox.ru

Cand. Sci. (Med.), Pirogov Russian National Research Medical University

Russian Federation, Moscow

Irina E. Baykova

Pirogov Russian National Research Medical University

Email: 1498553@mail.ru

Cand. Sci. (Med.), Pirogov Russian National Research Medical University

Russian Federation, Moscow

Vladimir A. Kislyakov

Pirogov Russian National Research Medical University

Email: kvadoctor@mail.ru

Cand. Sci. (Med.), Pirogov Russian National Research Medical University

Russian Federation, Moscow

Vyacheslav I. Svetlakov

Pirogov Russian National Research Medical University

Email: megadoc@mail.ru

Assistant, Pirogov Russian National Research Medical University

Russian Federation, Moscow

Irina V. Kovtyukh

Central Clinical Hospital of the Russian Academy of Sciences

Email: ivkovtuh@mail.ru

head of the Cardiology Department, Central Clinical Hospital of the Russian Academy of Sciences

Russian Federation, Moscow

Sergey A. Korvyakov

Central Clinical Hospital of the Russian Academy of Sciences

Email: wolna@yandex.ru

doctor, Central Clinical Hospital of the Russian Academy of Sciences

Russian Federation, Moscow

Alik M. Rakhaev

Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic

Email: alikrahaev@yandex.ru

D. Sci. (Med.), Main Bureau of Medical and Social Expertise in the Kabardino-Balkarian Republic

Russian Federation, Moscow

Igor G. Nikitin

Pirogov Russian National Research Medical University

Email: igor.nikitin.64@mail.ru

D. Sci. (Med.), Prof., Pirogov Russian National Research Medical University

Russian Federation, Moscow

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