Email this article Assessment of the effect of -blockers on the functional state in patients with ventricular arrhythmias: results of a comparative study
- Authors: Shubitidze I.Z.1, Tregubov V.G.2
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Affiliations:
- Regional Clinical Hospital №2
- Kuban State Medical University
- Issue: Vol 11, No 2 (2020)
- Pages: 23-27
- Section: Original study articles
- URL: https://journals.rcsi.science/2221-7185/article/view/46026
- DOI: https://doi.org/10.26442/22217185.2020.2.200266
- ID: 46026
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Abstract
Aim. Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with ventricular arrhythmias (VA).
Material and methods. 120 patients with VA against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: echocardiography, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram.
Results. With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol increased exercise tolerance to a greater extent, in comparison with bisoprolol and sotalol. Nebivolol and sotalol improved the quality of life, in comparison with bisoprolol.
Conclusion. In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.
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##article.viewOnOriginalSite##About the authors
Iosif Z. Shubitidze
Regional Clinical Hospital №2
Author for correspondence.
Email: iosif.shubitidze@mail.ru
ORCID iD: 0000-0002-4588-9515
cardiologist, Regional Clinical Hospital №2
Russian Federation, KrasnodarVitalii G. Tregubov
Kuban State Medical University
Email: iosif.shubitidze@mail.ru
ORCID iD: 0000-0003-0635-3598
D. Sci. (Med.), Kuban State Medical University
Russian Federation, KrasnodarReferences
- Priori SG, Blomström-Lundqvist C, Mazzanti A et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac Death. The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology. Eur Heart J 2015; 36 (41): 2793–867. doi: 10.1714/2174.23496
- Тарасов А.В. Вопросы безопасности антиаритмической терапии. Consilium Medicum. 2014; 16 (10): 44–9. [Tarasov A.V. Security issues in antiarrhythmic therapy. Consilium Medicum. 2014; 16 (10): 44–9 (in Russian).]
- Трешкур Т.В., Тулинцева Т.Э., Пармон Е.В. и др. Консервативная терапия неишемических желудочковых аритмий: опыт и перспектива. Кардиология и сердечно-сосудистая хирургия. 2013; 6 (5): 58–66. [Treshkur T.V., Tulintseva T.E., Parmon E.V. et al. Conservative treatment of non-ischemic ventricular arrhythmias: experience and prospects. Kardiologiya i serdechno-sosudistaya khirurgiya. 2013; 6 (5): 58–66 (in Russian).]
- Schleifer JW, Sorajja D, Shen WK. Advances in the pharmacologic treatment of ventricular arrhythmias. Expert Opin Pharmacother 2015; 16 (17): 2637–51. DOI: 10.1517/ 14656566.2015.1100170
- Прокофьев А.Б. Влияние антиаритмических лекарственных препаратов на качество жизни больных с нарушениями сердечного ритма. Лекарственные препараты и рациональная фармакотерапия. 2013; 1: 39–44. [Prokofiev A.B. Antiarrhythmic drugs influence on the quality of life of patients with heart rhythm disorders. Lekarstvennie preparati i racionalnaya farmakoterapiya. 2013; 1: 39–44 (in Russian).]
- Минушкина Л.О. Бисопролол: возможности в лечении артериальной гипертонии. Кардиология. 2012; 52 (6): 80–5. [Minuskina L.O. Bisoprolol: opportunities in the treatment of hypertension. Kardiologiia. 2012; 52 (6): 80–5 (in Russian).]
- Toblli JE, DiGennaro F, Giani JF et al. Nebivolol: impact on cardiac and endothelial function and clinical utility. Vascular Health and Risk Management. 2012; 8: 151–60. doi: 10.2147/vhrm.S20669
- Шубик Ю.В., Чирейкин Л.В. Соталол в лечении аритмий. Вестник аритмологии. 1998; 10: 80–3. [Shubik Y.V., Chireikin L.V. Sotalol in treatment of arrhythmias. Vestnik aritmologii. 1998; 10: 80–3 (in Russian).]
