A patient with arterial hypertension and a very high risk of complications: a role of a triple fixed drug combination


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Abstract

The article presents a clinical observation of a middle-aged patient with uncontrolled arterial hypertension and a very high cardiovascular risk. Correction of therapy in the form of adding a fixed combination of an angiotensine converting enzyme inhibitor, calcium antagonist and diuretic in maximum doses contributed to a decrease in the levels of office SBP and DBP by 24 and 16%, respectively, SBP and DBP according to daily monitoring of blood pressure - by 16%, SBP time index by 17.1%, DBP - by 37,4% and variability of SBP and DBP by 18 and 30%, respectively, as well as improved adherence to the treatment.

About the authors

V. N Larina

N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation

д-р мед. наук, зав. каф. поликлинической терапии лечебного фак-та 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1

D. A Orlov

N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation

117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1

V. P Sidorova

Diagnostic Center №1 of the Department of Health of Moscow

Email: larinav@mail.ru
канд. мед. наук, глав. врач 117485, Russian Federation, Moscow, ul. Miklukho-Maklaia, d. 29, korp. 2

References

  1. Чазова И.Е., Жернакова Ю.В., Ощепкова Е.В. и др. Распространенность факторов риска сердечно-сосудистых заболеваний в российской популяции больных артериальной гипертонией. Кардиология. 2014; 10: 4-12.
  2. Чазова И.Е. Артериальная гипертония в свете современных рекомендаций. Терапевтический архив. 2018; 90 (9): 4-7.
  3. Forouzanfar M, Liu P, Roth G et al. Global burden of hypertension and systolic blood pressure of at least 110 to 115 mm Hg, 1990-2015. JAMA 2017; 317: 165-82.
  4. Меna L.J, Maestre G.E, Hansen T.W et al. The behalf of the International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes (IDACO) Investigators How Many Measurements Are Needed to Estimate Blood Pressure Variability Without Loss of Prognostic Information? Am J Hypertens 2014; 27 (1): 46-55.
  5. Mancia G, Fagard R et al. ESH/ESC practice guidelines for the management of arterial hypertension. Blood Press 2014; 23: 3-16.
  6. Williams B, Mancia G, Spiering W et al. ESC Scientific Document Group; 2018 ESC/ESH Guidelines for the management of arterial hypertension, Eur Heart J 2018; 39 (33): 3021-104.
  7. Pall D, Szanto L, Szabo Z. Triple Combination Therapy in Hypertension: The Antihypertensive Efficacy of treatment with Perindopril, Amlodipine, and Indapamide SR. Clin Drug Investig 2014; 34 (10): 701-8.
  8. Остроумова О.Д., Кочетков А.И., Павлеева Е.Е., Гусева Т.Ф. Современные представления о выборе фиксированных комбинаций антигипертензивных препаратов: фокус на эффективность и прогноз. Лечебное дело. 2018; 2: 39-48.
  9. Morisky D.E, Ang A, Krousel-Wood M, Harry J. Ward. Predictive validity of a medication adherence measure in an outpatient setting. J Clin Hypertens (Greenwich) 2008; 10 (5): 348-54.
  10. Ferreire S.A. bradykinin-potentiating factor (BPF) present in the venom of Bothrops jararaca. Br J Pharmacol 1965; 24:163-9.
  11. Gavras H, Brunner H.R, Turini G.A et al. Antihypertensive effect of the oral angiotensin convertingenzyme inhibitor SQ 14225 in man. N Engl J Med 1978; 298 (18): 991-5.
  12. Yang L, Zhang J, Li N et al. Bradykinin receptor in immune-mediated renal tubular injury in trichloroethylene-sensitized mice: Impact on NF-kB signaling pathway. J Immunotoxicol 2018; 15 (1): 126-36.
  13. Yousif M, Benter I, Diz D, Chappell M. Angiotensin-(1-7)-dependent vasorelaxation of the renal arteryexhibitsunique angiotensin and bradikinin receptor selektivity. Peptides 2017; 90: 10-6.
  14. Gouni-Berthoid Hanssen R, Ravarani L, Berthold H. Management of Blood Pressure and Heart Rate in Patients with Diabetes Mellitus. Curr Pharm Des 2017; 23 (31): 4573-82.
  15. Jicheng L, Jicheng L, Perkovic V, Foote C.V. Antihypertensive agents for preventing diabetic kidney disease. Cochrane Database Syst Rev 2012; 12: CD004136.
  16. PROGRESS Collaborative Study Group. Randomised trial of perindopril based blood pressure-lowering regimen among 6108 individuals with previous stroke or transient ischaemic attack. Lancet 2001; 358 (9287): 1033-41.
  17. Fox K, Henderson J, Bertrand M et al. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003; 362 (9386): 782-8.
  18. Dahlof B, Sever P, Poulter N et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomized controlled trial. Lancet 2005; 366 (9489): 895-906.
  19. Ferrari R. Perindopril and Remodeling in Elderly with Acute Myocardial Infarction Investigators. Effects of angiotensin-converting enzyme inhibition with perindopril on left ventricular remodeling and clinical outcome: results of the randomized Perindopril and Remodeling in Elderly with Acute Myocardial Infarction (PREAMI) Study. Arch Intern Med 2006; 166 (6): 659-66.
  20. Parati G, Dolan E, Schumacher H. Impact of antihypertensive combination and monotreatments on blood pressure variability: assessment by old and new indices. Data from a large ambulatory blood pressure monitoring database. J Hypertens 2014; 32 (6): 1326-33.
  21. Musini V, Nazer M, Bassett K, Wright J. Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension. Cochrane Database Syst Rev 2014; 29; (5).
  22. Леонова М.В., Белоусов Ю.Б., Штейнберг Л.Л. и др. Результаты фармакоэпидемиологического исследования артериальной гипертонии ПИФАГОР IV (опрос пациентов с артериальной гипертонией). Системные гипертензии. 2015; 12 (3): 11-8.
  23. Ábrahám G, Dézsi C. The Antihypertensive Efficacy of the Triple Fixed Combination of Perindopril, Indapamide, and Amlodipine: The Results of the PETRA Study. Adv Ther 2017; 34 (7): 1753-63.
  24. Tóth K. PIANIST Investigators. Antihypertensive efficacy of triple combination perindopril/indapamide plus amlodipine in high-risk hypertensives: results of the PIANIST study (Perindopril-Indapamide plus AmlodipiNe in high rISk hyperTensive patients). Am J Cardiovasc Drugs 2014; 14 (2): 137-45.
  25. Mourad J, Amodeo C, de Champvallins M et al. Blood pressure-lowering efficacy and safety of perindopril/indapamide/amlodipine single-pill combination in patients with uncontrolled essential hypertension: a multicenter, randomized, double-blind, controlled trial. J Hypertens 2017; 35 (7): 1481-95. doi: 10.1097/HJH.0000000000001359
  26. Chalmers J, Arima H, Woodward M et al. Effects of combination of perindopril, indapamide, and calcium channel blockers in patients with type 2 diabetes mellitus: results from the Action In Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial. Hypertension 2014; 63: 259-64.
  27. Кобалава Ж.Д., Троицкая Е.А., Толкачева В.В. Комбинированная терапия артериальной гипертонии с использованием трехкомпонентной фиксированной комбинации амлодипина, индапамида и периндоприла аргинина в клинической практике: организация и основные результаты программы ДОКАЗАТЕЛЬСТВО. Кардиология. 2018; 58 (9): 21-30
  28. Горбунов В.М. Современные представления о вариабельности артериального давления. Рациональная фармакотерапия в кардиологии. 2012; 8 (6): 810-8. / Gorbunov V.M. Sovremennye predstavleniia o variabel'nosti arterial'nogo davleniia. Ratsional'naia farmakoterapiia v kardiologii. 2012; 8 (6): 810-8. [in Russian]
  29. Феськова А.А., Кравченко А.Я. Особенности клинического течения гипертонической болезни на фоне субклинической гипофункции щитовидной железы. Системный анализ и управление в биомедицинских системах. 2015; 14 (3): 473-6. [in Russian]
  30. Кравченко А.Я., Черных А.А., Будневский А.В. Вариабельность артериального давления у больных артериальной гипертензией и избыточной массой тела. Кардиоваск. терапия и профилактика. 2016; 15 (S): 100.
  31. Lalić J., Radovanović R., Mitić B. et al. Medication Adherence in Outpatients with Arterial Hypertension. Sci J Fac Med Niš 2013; 30: 209-18

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