The use of B vitamins in the treatment of polyneuropathy of different genesis


Cite item

Full Text

Abstract

Deficiency of B vitamins takes part in the pathogenesis of a number of diseases central and peripheral nervous system. The vitamins of this group are among the the most commonly used drugs in neurology. A widely known indication for the appointment of vitamins of group B is a pain syndrome in neuropathies, that they have their own analgesic effect. A lot of experience has been accumulated clinical application of B vitamins and their clinical effectiveness: more than 100 studies were conducted on both the individual and joint use of vitamins B1, B6 and B12 and their combination with analgesics in the complex therapy of pain syndrome. The article summarizes the data of experimental works and clinical studies of the effectiveness of vitamin B group therapy for peripheral nervous system and pain syndrome, as well as a clinical case of therapy аlcoholic polyneuropathy with injectable drug Neuromultivit

About the authors

A. A Pilipovich

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: aapilipovich@mail.ru
канд. мед. наук, доц. каф. нервных болезней 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

References

  1. Строков И.А., Ахмеджанова Л.Т., Солоха О.А. Витамины группы В в лечении неврологических заболеваний. РМЖ. Неврология. Психиатрия. 2009; 11: 776-84.
  2. Nardin R.A, Amic A.N, Raynor E.M. Vitamin B12 and methylmalonic acid levels in patients presenting with polyneuropathy. Muscle Nerve 2007; 36 (4): 532-5.
  3. Данилов А.Б., Данилов Ал.Б. Управляй болью. Биопсихосоциальный подход. М.: АММ ПРЕСС, 2012: 582.
  4. Воробьева О.В. Диабетическая нейропатия: некоторые вопросы распространенности, патогенеза и лечения. РМЖ. Неврология. Психиатрия. 2009; 11: 748-51.
  5. Dror D.K, Allen L.H. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008; 5: 250-5.
  6. Луцкий И.С., Лютикова Л.В., Луцкий Е.И. Витамины группы В в неврологической практике. Междунар. неврологический журн. 2008; 5.
  7. Mauro G.L, Martorana U, Cataldo P et al. Vitamin B12 in low back pain: a randomised, double-blind, placebo-controlled study. Eur Rev Med Pharmacol Sci 2000; 4 (3): 53-8.
  8. Talaei A, Siavash M, Majidi H et al. Vitamin B12 may be more effective than nortriptyline in improving painful diabetic neuropathy. Int J Food Sci Nutr 2009; 60 (Suppl. 5): 71-6.
  9. Chiu C.K, Low T.H, Tey Y.S et al. The efficacy and safety of intramuscular injections of methylcobalamin in patients with chronic nonspecific low back pain: a randomised controlled trial. Singapore Med J 2011; 52 (12): 868-73.
  10. Данилов А.Б. Применение витаминов группы В при болях в спине: новые анальгетики? РМЖ. 2008; 16: 35-3.
  11. Лечение бенфотиамином. Мильгамма. Научный обзор.
  12. Merete C, Falcon L.M, Tucker K.L. Vitamin B6 is associated with depressive symptomatology in Massachusetts elders. J Am Coll Nutr 2008; 3: 421-7.
  13. Scott K, Zeris S, Kothari M.J. Elevated B6 levels and peripheral neuropathies. Electromyogr Clin Neurophysiol 2008; 5: 219-23.
  14. Анисимова Е.И., Данилов А.Б. Эффективность бенфотиамина в лечении алкогольной полиневропатии. Журн. неврологии и психиатрии им. С.С.Корсакова. 2001; 4: 216-21.
  15. Kasdan M, Janes C. Carpal tunnel syndrome and vitamin B6. Plast Reconstr Surg 1987; 79: 456-8.
  16. Aufiero E, Stitik T, Foye M et al. Piridoxine hydrochloride treatment of carpal tunnel syndrome: a review. Nutr Rev 2004; 3: 96-104.
  17. Katan M.B. How much vitamin B6 is toxic? Ned Tijdschr Geneeskd 2005; 46: 2545-6.
  18. Bettendorff L, Kolb H.A, Schoffeniels E. Thiamine triphosphate activates anion channels of large unit conductance in neuroblastoma cells. J Membr Biol 1993; 136: 281-8.
  19. Bа A. Metabolic and structural role of thiamine in nervous tissues. Cell Mol Neurobiol 2008; 7: 923-31.
  20. Дамулин И.В. Терапевтические возможности применения препарата Тригамма® в неврологической практике. Справ. врача общей практики. 2011; 7: 28-35.
  21. Gibson G.E, Blass J.P. Thiamine-dependent processes and treatment strategies in neurodegeneration. Antioxid Redox Signal 2007; 9: 1605-10.
  22. Ang C.D, Alviar M.J, Dans A.L et al. Vitamin B for treating peripheral neuropathy. Cochrane Database Syst Rev 2008; 3: CD004573.
  23. Старчина Ю.А. Витамины группы В в лечении заболеваний нервной системы. Неврология, нейропсихиатрия, психосоматика. 2009; 2: 84-7.
  24. Bruggemann G, Koehler C.O, Koch E.M. Results of a double-blind study of diclofenac + vitamin B1, B6, B12 versus diclofenac in patients with acute pain of the lumbar vertebre. A multicenter study. Klein Wochenschr 1990; 2: 116-20.
  25. Kulwein A, Meyer H.J, Koehler C.O. Reduced diclofenac administration by B vitamins: results of a randomized double-blined study with reduced daily doses of diclofenac (75 mg diclofenac versus 75 mg diclofenac plus B vitsmins) in acute lumbar vertebral syndromes. Klein Wochenschr 1990; 2: 107-15.
  26. Zeng L, Alongkronrusmee D, van Rijn R.M. An integrated perspective on diabetic, alcoholic, and drug-induced neuropathy, etiology, and treatment in the US. J Pain Res 2017; 10: 219-28.
  27. Xu Z, Zhang P, Long L et al. Diabetes mellitus in classical trigeminal neuralgia: a predisposing factor for its development. Clin Neurol Neurosurg 2016; 151: 70-2.
  28. Левин О.С. Полиневропатии: Клиническое руководство. М., 2011; с. 161-221
  29. Tesfaye S, Boulton A.J, Dickenson A.H. Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care 2013; 36: 2456-65.
  30. Калинин А.П., Котов С.В., Рудакова И.Г. Неврологические расстройства при эндокринных заболеваниях. Руководство для врачей. 2-е изд. М.: Медицинское информационное агентство, 2009; с. 235-300.
  31. Шнайдер Н.А., Петрова М.М., Киричкова Г.А. Диабетическая нейропатия: дефиниция, классификация, факторы риска. Вестн. НГУ. Серия: Биология, клиническая медицина. 2008; 6 (Вып. 1): 67-72.
  32. Xu L, Huang Z, He X et al. Adverse effect of metformin therapy on serum vitamin B12 and folate: short-term treatment causes disadvantages? Med Hypotheses 2013; 2: 149-51.
  33. Громова О.А., Стаховская Л.В., Торшин И.Ю., Томилова И.К. Прием метформина провоцирует нарушения гомеостаза витамина В12. Consilium Medicum. 2017; 19 (4): 8-14.
  34. Емельянова А.Ю., Зиновьева О.Е. Алкогольная полиневропатия: клинико-патогенетические варианты, принципы диагностики и лечения. Эффективная фармакотерапия. Неврология. 2015; 2.
  35. Левин О.С. Полинейропатии. Клиническое руководство. М., 2005.
  36. Ангельчева О.И., Зиновьева О.Е., Яхно Н.Н. Нервно-мышечные нарушения при хроническом алкоголизме: учебное пособие. М.: МЕДпресс-Информ, 2009.
  37. Zambelis T, Karandreas N, Tzavellas E et al. Large and small fiber neuropathy in chronic alcohol-dependent subject. J Peripher Nerv Syst 2005; 4: 375-81.
  38. Пилипович А.А., Русая В.В. Применение тиоктовой кислоты в терапии полиневропатий. Consilium Medicum. 2017; (9): 97-101. doi: 10.26442/2075-1753_19.9.97-101
  39. Воробьева О.В., Тверская Е.П. Алкогольная полиневропатия. Consilium Medicum. 2005; 7 (2): 138-42.
  40. Chopra K, Tiwari V. Alcoholic neuropathy: possible mechanisms and future treatment possibilities. Br J Clin Pharmacol 2012; 3: 348-62.
  41. Peters T.J, Kotowicz J, Nyka W et al. Treatment of alcoholic polyneuropathy with vitamin B complex: a randomized controlled trial. Alcohol Alcohol 2006; 6: 636-42.

Copyright (c) 2018 Eco-Vector

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies