Lipotoxicity damage of myocardium in obesity


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Abstract

In this article discusses the main mechanisms of development lipolitic damage of myocardial and morphological and structural changes of the heart in obesity.

About the authors

O. V Gritsenko

Altay Regional Cardiological Dispensary; Science Research Institute for Complex Issues of Cardiovascular Diseases

канд. мед. наук, врач-кардиолог, науч. сотр. 656055, Russian Federation, Barnaul, ul. Malakhova, d. 46

G. A Chumakova

Science Research Institute for Complex Issues of Cardiovascular Diseases; Altay State Medical University of the Ministry of Health of the Russian Federation

Email: g.a.chumakova@mail.ru
д-р мед. наук, проф. каф. терапии и общей врачебной практики ФПК и ППС, вед. науч. сотр. 650002, Russian Federation, Kemerovo, Sosnovyi bul., d. 6

S. A Elchaninova

Altay State Medical University of the Ministry of Health of the Russian Federation

д-р биол. наук, проф., зав каф. биохимии и клинической лабораторной диагностики 656038, Россия, Барнаул, пр-т Ленина, д. 40

N. G Veselovskaya

Altay Regional Cardiological Dispensary; Science Research Institute for Complex Issues of Cardiovascular Diseases

д-р мед. наук, зав. кардиологическим отд-нием №4, ст. науч. сотр. 656055, Russian Federation, Barnaul, ul. Malakhova, d. 46

I. V Shevlyakov

Altay Regional Cardiological Dispensary

Email: preobrajensky89@mail.ru
врач 656055, Russian Federation, Barnaul, ul. Malakhova, d. 46

O. A Kalugina

Altay Regional Cardiological Dispensary

Email: heartdoc@mail.ru
врач 656055, Russian Federation, Barnaul, ul. Malakhova, d. 46

References

  1. Berrington de Gonzalez A, Hartge P, Cerhan J.R. et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med 2010; 363: 2211-9.
  2. Wende A.R, Abel E.D. Lipotoxicity in the Heart. Biochim Biophys Acta 2010; 1801 (3): 311-9.
  3. Асташкин Е.И., Глезер М.Г. Липотоксические эффекты в средце, наблюдаемые при ожирении. Артериальная гипертензия. 2009; 15 (3): 335-41.
  4. Ritchie R.H. Evidence for a causal role of oxidative stress in the myocardial complications of insulin resistance. Heart Lung Circ 2009; 18 (1): 11-8.
  5. Drosatos K, Schulze P.C. Cardiac Lipotoxicity: Molecular Pathways and Therapeutic Implications. Curr Heart Fail Rep 2013; 10 (2): 109-21.
  6. Nanayakkara G, Kariharan T, Wang L. et al. The cardio-protective signaling and mechanisms of adiponectin. Am J Cardiovasc Dis 2012; 2 (4): 253-66.
  7. Haffar T, Bérubé-Simard F, Bousette N. Impaired fatty acid oxidation as a cause for lipotoxicity in cardiomyocytes. Biochem Biophys Res Commun 2015; 468 (1-2): 73-8.
  8. Augustus A.S, Buchanan J, Park T.S. et al. Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction. J Biol Chem 2006; 281: 8716-23.
  9. Drosatos K, Bharadwaj K.G, Lymperopoulos A. et al. Cardiomyocyte lipids impair beta-adrenergic receptor function via pkc activation. Am J Physiol Endocrinol Metab 2011; 300: E489-499.
  10. Gaborti B, Kober F, Jacquier A et al. Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat. Int J Obes (Lond) 2012; 36 (3): 422-30.
  11. McGavock J.M, Lingvay I, Zib.I et al. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation 2007; 116 (10): 1170-5.
  12. Wende A.R, Symons J.D, Abel E.D. Mechanisms of Lipotoxicity in the Cardiovascular System. Curr Hypertens Rep 2012; 14 (6): 517-31.
  13. Stratford S, Hoehn K.L, Liu F. et al. Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of akt/protein kinase b. J Biol Chem 2004; 279: 36608-15.
  14. Son N.H, Park T.S, Yamashita H. et al. Cardiomyocyte expression of ppargamma leads to cardiac dysfunction in mice. J Clin Invest 2007; 117: 2791-801.
  15. Boudina S, Abel E.D. Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord 2010; 11: 31-9.
  16. Mewton N, Ying L.C, Pierre С. et al. Assessment of myocardial fibrosis with cardiac magnetic resonance. J Am Coll Cardiol 2011; 57 (8): 891-903.
  17. Kwon D.H, Halley C.M, Popovic Z.B. et al. Gender differences in survival in patients with severe left ventricular dysfunction despite similar extent of myocardial scar measured on cardiac magnetic resonance. Eur J Heart Fail 2009; 11: 937-44.
  18. Martos R, Baugh J, Ledwidge M et al. Diastolic heart failure: evidence of increased myocardial collagen turnover linked to diastolic dysfunction. Circulation 2007; 115: 888-895.
  19. Lopez B, Gonzalez A, Beaumont J. et al. Identification of a potential cardiac antifibrotic mechanism of torasemide in patients with chronic heart failure. J Am Coll Cardiol 2007; 50: 859-67.
  20. Eguchi K, Boden-Albala B, Jin Z. et al. Association between diabetes mellitus and left ventricular hypertrophy in a multiethnic population. Am J Cardiol 2008; 101 (12): 1787-91.
  21. Woodiwiss A.J, Libhaber C.D, Majane O.H. et al. Obesity promotes left ventricular concentric rather than eccentric geometric remodeling and hypertrophy independent of blood pressure. Am J Hypertens 2008; 21 (10): 1144-51.
  22. Kim M, Oh J.K, Sakata S. et al. Role of resistin in cardiac contractility and hypertrophy. J Mol Cell Cardiol 2008; 45 (2): 270-80.
  23. Bahrami H, Bluemke D.A, Kronmal R. et al. Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. J Am Coll Cardiol 2008; 51 (18): 1775-83.
  24. Brooks B.A, Franjic B, Ban C.R. et al. Diastolic dysfunction and abnormalities of the microcirculation in type 2 diabetes. Diabetes Obes Metab 2008; 10 (9): 739-46.
  25. Hsueh W, Abel E.D, Breslow J.L et al. Recipes for creating animal models of diabetic cardiovascular disease. Circ Res 2007; 100 (10): 1415-27.
  26. Greulich S, De Wiza D.H, Preilowksi S.et al. Secretory products of guinea pig epicardial fat induce insulin resistance and impair primary adult rat cardiomyocyte function. J Cell Mol Med 2011; 15: 2399-410.
  27. Huang G, Wang D, Zeb I. et al. Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS). Atherosclerosis 2012; 221: 198-205.
  28. Iacobellis G. Relation of epicardial fat thickness to right ventricular cavity size in obese subjects. Am J Cardiol 2009; 104 (11): 601-2. doi: 10.1016/j.amjcard.2009.07.032.
  29. Iacobellis G, Leonetti F, Singh N et al. Relationship of epicardial adipose tissue with atrial dimensions and diastolic function in morbidly obese subjects. Int J Cardiol 2007; 115 (2): 272-3.
  30. Mookadam F, Goel R, Alharthi M.S. Epicardial Fat and Its Association with Cardiovascular Risk: A Cross-Sectional Observational Study. Heart Views 2010; 11(3): 103-8.
  31. Kilicaslan B, Ozdogan O, Aydin M et al. Increased epicardial fat thickness is associated with cardiac functional changes in healthy women. J Exp Med 2012; 228 (2): 119-24.
  32. Веселовская Н.Г., Чумакова Г.А., Отт О.В. и др. Особенности ремоделирования миокарда и его функций у больных с эпикардиальным ожирением. Сердечная недостаточность. 2013; 5 (79): 247-51

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