Risk factors of subclinical atherosclerosis of obesity women


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Abstract

Research objective: study the metabolic risk factors (RF) of subclinical atherosclerosis of obese women. Material and methods. 89 women have been included in research, 50.6±6.6 years old with abdominal obesity and waist circumference >80 cm without coronary heart disease and atherosclerosis of other localisation. According to the results of the ultrasound study of brachiocephalic arteries (BCA), two groups were formed for comparison: Group 1 (n=60) without atherosclerosis BCA, Group 2 (n=29) with atherosclerosis BCA. Definitions of classical and additional metabolic RF, of adipokines of visceral adipose tissue (VAT) and ghrelin were spent to the surveyed patients. The thickness of epicardial fat (tEF) was defined at transthoracic echocardiography. Results. In the group 2 there were the highest indexes of: LDL 3.7 (2.9; 4.6) mmol/L, Apo B 1.32±0.29 g/L, CRP 2.8±0.96 mg/l, leftin 20.0 (16.4; 23.1) ng/ml, tEF 7 (6; 8) mm; lower indexes of Apo A1 1.16±0.31 g/l and ghrelin 40.7 (39.1; 42.8) pg/dl. Conclusion. The signs of subclinical atherosclerosis of the carotid arteries of obese women were associated with higher amount of VAT (tEF), inflammatory activity of plasma (CRP) and neurohumoral disorders (leftin, ghrelin).

About the authors

N. N Shenkova

Altay State Medical University of the Ministry of Health of the Russian Federation; Sanatorium «Russia»

Email: ninashenkova@mail.ru
аспирант каф. терапии и общей врачебной практики с курсом ДПО ФГБОУ ВО АГМУ, врач-кардиолог ЗАО «Санаторий “Россия”» 656038, Russian Federation, Barnaul, pr-t Lenina, d. 40; 659900, Russian Federation, Belokurikha, ul. Slavskogo, d. 34

G. A Chumakova

Altay State Medical University of the Ministry of Health of the Russian Federation; Research Institute for Complex Issues of Cardiovascular Diseases

Email: g.a.chumakova@mail.ru
д-р мед. наук, проф. каф. терапии и общей врачебной практики с курсом ДПО ФГБОУ ВО АГМУ, вед. науч. сотр. ФГБНУ НИИ КПССЗ 656038, Russian Federation, Barnaul, pr-t Lenina, d. 40; 650002, Russian Federation, Kemerovo, Sosnovyi b-r, d. 6

N. G Veselovskaya

Research Institute for Complex Issues of Cardiovascular Diseases; Altay Regional Cardiology Dispensary

Email: nadezhda100@rambler.ru
д-р мед. наук, ст. науч. сотр. ФГБНУ НИИ КПССЗ, зав. отд-нием КГБУЗ АККД 650002, Russian Federation, Kemerovo, Sosnovyi b-r, d. 6; 656055, Russian Federation, Barnaul, ul. Malakhova, d. 46

E. S Osipova

Altay State Medical University of the Ministry of Health of the Russian Federation

Email: agmu_elena@mail.ru
аспирант каф. терапии и общей врачебной практики с курсом ДПО ФГБОУ ВО АГМУ 656038, Russian Federation, Barnaul, pr-t Lenina, d. 40

A. V Ott

Altay State Medical University of the Ministry of Health of the Russian Federation; Altay Regional Cardiology Dispensary

Email: ott-88@mail.ru
аспирант каф. терапии и общей врачебной практики с курсом ДПО ФГБОУ ВО АГМУ, врач-кардиолог КГБУЗ АККД 656038, Russian Federation, Barnaul, pr-t Lenina, d. 40; 656055, Russian Federation, Barnaul, ul. Malakhova, d. 46

References

  1. Оганов Р.Г., Масленникова Г.Я. Демографические тенденции в Российской Федерации: вклад болезней системы кровообращения. Междунар. журн. сердца и сосудистых заболеваний. 2013; 1 (1): 3-10.
  2. Нейфельд И.В., Жирняков А.И., Скупова И.Н. Факторы риска сердечно - сосудистых заболеваний женщин. Бюл. мед. интернет - конференций. 2012; 12 (2): 1001-3.
  3. Sallam T, Watson K.E. Predictors of cardiovascular risk in women. Womens Health (Lond) 2013; 9 (5): 491-8.
  4. Бойцов С.А., Кухарчук В.В., Карпов Ю.А. и др. Субклинический атеросклероз как фактор риска сердечно - сосудистых осложнений. Кардиоваск. терапия и профилактика. 2012; 11 (3): 82-6.
  5. Вельков В.В. Высокочувствительные кардиальные маркеры и реклассификация сердечно - сосудистых рисков. Клинико - лабораторный консилиум. 2012; 1 (41): 47-52.
  6. Jaffer F.A, O'Donnell C.J, Larson M.G. Age and sex distribution of subclinical aortic atherosclerosis: a magnetic resonance imaging examination of the Framingham Heart Study. Arterioscler Thromb Vasc Biol 2002; 22: 849-54.
  7. Johnson M. Ultrasonography in the diagnosis of subclinical atherosclerosis. 2013.
  8. Mitchell S, Shaw D. The worldwide epidemic of female obesity. Best Pract Res Clin Obstet Gynaecol 2015; 29 (3): 289-99.
  9. Rabkin S.W. Epicardial fat: properties, function and relationship to obesity. Obes Rev 2007; 8 (3): 253-61.
  10. Macut D, Bačević M, Božić-Antić I et al. Predictors of subclinical cardiovascular disease in women with polycystic ovary syndrome: interrelationship of dyslipidemaia and arterial blood pressure. Int J Endocrinol 2015; 2015: 812610.
  11. Maturana M.A, Franz R.F, Metzdorf M et al. Subclinical cardiovascular disease in postmenopausal women with low/medium cardiovascular risk by the Framingham risk score. Maturitas 2015; 81 (2): 311-6.
  12. Fagerberg B, Prah Gullberg U, Alm R et al. Circulating autoantibodies against the apolipoprotein B-100 peftides p45 and p210 in relation to the occurrence of carotid plaques in 64 - year - old women. PLoS One 2015; 10 (3).
  13. Munjal Y.P, Surendra K. API Textbook of Medicine, Ninth Edition, Two Volume. Jay Pee Brothers, 2012; p. 663.
  14. Чумакова Г.А., Веселовская Н.Г., Отт А.В. и др. Альтернативный способ оценки висцерального ожирения при диагностике метаболического синдрома. Рос. кардиол. журн. 2014; 3: 82-6.
  15. Molica F, Morel S, Kwak B.R et al. Adipokines at the crossroad between obesity and cardiovascular disease. Thromb Haemost 2015; 113 (3): 553-66.
  16. Yañez-Rivera T.G, Baños-Gonzalez M.A, Ble-Castillo J.L et al. Relationship between epicardial adipose tissue, coronary artery disease and adiponectin in a Mexican population. Cardiovasc Ultrasound 2014; 12: 35.
  17. Чумакова Г.А., Веселовская Н.Г., Гриценко О.В. и др. Эпикардиальное ожирение как фактор риска развития коронарного атеросклероза. Кардиология. 2013; 53 (1): 51-5.
  18. Cakir E, Doğan M, Topaloglu O et al. Subclinical atherosclerosis and hyperandrogenemia are independent risk factors for increased epicardial fat thickness in patients with PCOS and idiopathic hirsutism. Atherosclerosis 2013; 226 (1): 291-5.
  19. Huang G, Wang D, Zeb I et al. Intra - thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen Prevention Study (KEEPS). Atherosclerosis 2012; 221 (1): 198-205.
  20. Арабидзе Г.Г. Клиническая иммунология атеросклероза от теории к практике. Атеросклероз и дислипидемии. 2013; 1 (10): 4-19.
  21. Oh E.G, Kim S.H, Bang S.Y et al. High - sensitivity C-reactive protein is independently associated with arterial stiffness in women with metabolic syndrome. J Cardiovasc Nurs 2012; 27 (1): 61-7.
  22. Nahas E.A, Nahas-Neto J, Orsatti C.L et al. Evaluation of clinical and inflammatory markers of subclinical carotid atherosclerosis in postmenopausal women. Menopause 2014; 21 (9): 982-9.
  23. Веселовская Н.Г., Чумакова Г.А., Козаренко А.А., Бокслер М.И. Адипокины как корригируемый фактор риска сердечно - сосудистых заболеваний. Рос. кардиол. журн. 2010; 6 (86): 88-93.
  24. Mc Mahon M, Skaggs B.J, Sahakian L et al. High plasma leftin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids. Ann Rheum Dis 2011; 70 (9): 1619-24.
  25. Ukkola O. Ghrelin and atherosclerosis. Curr Opin Lipidol 2015; 26 (4): 288-91.
  26. Zhang M, Fang W.Y, Yuan F et al. Plasma ghrelin levels are closely associated with severity and morphology of angiographically - detected coronary atherosclerosis in Chineses patients with diabetes mellitus. Аcta Pharmacologica Sinica 2012; 33: 452-8.
  27. Zwirska-Korczala K, Sodowski K, Konturek S.J et al. Postprandial response of ghrelin and PYY and indices of low - grade chronic inflammation in lean young women with polycystic ovary syndrome. J Physiol Pharmacol 2008; 59 (Suppl. 2): 161-78.
  28. Buss J, Havel P.J, Epel E et al. Associations of ghrelin with eating behaviors, stress, metabolic factors, and telomere length among overweight and obese women: preliminary evidence of attenuated ghrelin effects in obesity. Appetite 2014; 76: 84-94.
  29. Pop D, Peter P, Dădârlat A et al. Serum ghrelin level is associated with cardiovascular risk score. Rom J Intern Med 2015; 53 (2): 140-5.
  30. Pöykkö S.M, Kellokoski E, Ukkola O et al. Plasma ghrelin concentrations are positively associated with carotid artery atherosclerosis in males. Intern Med 2006; 260 (1): 43-52.

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