Association of polymorphisms of chromosome 4q25 in patients with atrial fibrillation

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Abstract

The article deals with the issue of genetic determination of atrial fibrillation. In particular, it is shown that a rare polymorphism rs2200733 T allele on chromosome 4q25 statistically more frequently (p=0,029) in patients with atrial fibrillation compared with the control group data. The question of the functional significance of this polymorphism in the development of electrical instability of the atrial myocardium is also addressed.

About the authors

V. A Shulman

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: shulman36@mail.ru
д-р. мед. наук, проф. каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

S. Yu Nikulina

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: nicoulina@mail.ru
д-р мед. наук, проф., зав. каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

E. E Poplavskaya

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: alenka21121@mail.ru
ординатор каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

V. N Maksimov

Scientific research institute of therapy and prophylactic medicine

Email: medik11@mail.ru
зав. лаб. молекулярно-генетических исследований терапевтических заболеваний ФГБНУ НИИТПМ 630089, Russian Federation, Novosibirsk, ul. Borisa Bogatkova, d. 175/1

N. V Aksyutina

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

Email: aks-n-v@yandex.ru
канд. мед. наук, ассистент каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

B. V Nazarov

Prof. V.F.Voino-Yasenetski Krasnoyarsk State Medical University of the Ministry of Health of the Russian Federation

канд. мед. наук, доц. каф. внутренних болезней №1 ГБОУ ВПО КрасГМУ им. проф. В.Ф.Войно-Ясенецкого 660022, Russian Federation, Krasnoyarsk, ul. Partizana Zhelezniaka, d. 1

References

  1. Диагностика и лечение фибрилляции предсердий. Рекомендации РКО, ВНОА и АССХ. Рос. кардиол. журн. 2013; 4 (Прил. 3).
  2. Gudbjartsson D.F, Arnar D.O, Helgadottir A et al. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007; 448 (7151): 353-7.
  3. Ferran A, Alegret J.M, Subirana I et al. Association between rs2200733 and rs7193343 genetic variants and atrial fibrillation in a Spanish population, and meta - analysis of previous studies. Rev Esp Cardiol (Engl Ed) 2014; 67 (10): 822-9.
  4. Mohanty S, Santangeli P, Bai R et al. Variant rs2200733 on chromosome 4q25 confers increased risk of atrial fibrillation: evidence from a meta - analysis. J Cardiovasc Electrophysiol 2013; 24 (2): 155-61.
  5. Olesen M.S, Holst A.G, Jabbari J et al. Genetic loci on chromosomes 4q25, 7p31, and 12p12 are associated with onset of lone atrial fibrillation before the age of 40 years. Can J Cardiol 2012; 28 (2): 191-5.
  6. Kiliszek M, Franaszczyk M, Kozluk E et al. Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population. PLoS One 2011; 6 (7): e21790.
  7. Goodloe A.H, Herron K.J, Olson T.M. Uncovering an intermediate phenotype associated with rs2200733 at 4q25 in lone atrial fibrillation. Am J Cardiol 2011; 107 (12): 1802-5.
  8. Lubitz S.A, Sinner M.F, Lunetta K.L et al. Independent susceptibility markers for atrial fibrillation on chromosome 4q25. Circulation 2010; 122 (10): 976-84.
  9. Lee K.T, Yeh H.Y, Tung C.P et al. Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population. Cardiology 2010; 116 (3): 151-6.
  10. Viviani Anselmi C, Novelli V, Roncarati R et al. Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population. Heart 2008; 94 (11): 1394-6.
  11. Shi L, Li C, Wang C et al. Assessment of association of rs2200733 on chromosome 4q25 with atrial fibrillation and ischemic stroke in a Chinese Han population. Hum Genet 2009; 126 (6): 843-9.
  12. Kirchhof P, Bax J, Blomstrom-Lundquist C et al. Early and comprehensive management of atrial fibrillation: executive summary of the proceedings from the 2nd AFNET-EHRA consensus conference 'research perspectives in AF'. Eur Heart J 2009; 30 (24): 2969-77.
  13. Page S.P, Siddiqui M.S, Finlay M et al. Catheter ablation for atrial fibrillation on uninterrupted warfarin: can it be done without echo guidance? J Cardiovasc Electrophysiol 2011; 22 (3): 265-70.

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