Biochemical predictors of coronary atherosclerosis in patients with metabolic disorders

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Abstract

Metabolic syndrome represents a combination of different major risk factors of cardiovascular diseases and is mainly related to impaired insulin sensitivity in biological tissues. Common understanding of pathogenesis and relationship of different pathological conditions within metabolic syndrome is still missing. New data on endocrine function of adipose tissue suggests that development and progression of atherosclerosis in this situation may be related to adipokines dysbalance. This study investigates correlation of leptin and adiponectin with clinical and laboratory changes in patients with metabolic disorders.

About the authors

E. M Surkichin

A.N.Bakulev Scientific Center of Cardiovascular Surgery

Email: elena.surkichina@yandex.ru
канд. мед. наук, врач-кардиолог клинико-диагностического отд-ния ФГБНУ НЦССХ им. А.Н.Бакулева 121552, Russian Federation, Moscow, Rublevskoe sh., d. 135

I. P Shuvaev

A.N.Bakulev Scientific Center of Cardiovascular Surgery

канд. мед. наук, врач-кардиолог клинико-диагностического отд-ния ФГБНУ НЦССХ им. А.Н. Бакулева 121552, Russian Federation, Moscow, Rublevskoe sh., d. 135

E. U Asymbekova

A.N.Bakulev Scientific Center of Cardiovascular Surgery

д-р мед. наук, вед. науч. сотр. клинико-диагностического отд-ния ФГБНУ НЦССХ им. А.Н.Бакулева 121552, Russian Federation, Moscow, Rublevskoe sh., d. 135

S. T Matskeplishvili

A.N.Bakulev Scientific Center of Cardiovascular Surgery

д-р мед. наук, проф., гл. науч. сотр. клинико-диагностического отд-ния ФГБНУ НЦССХ им. А.Н.Бакулева 121552, Russian Federation, Moscow, Rublevskoe sh., d. 135

References

  1. Cook S, Weitzman M, Auinger P et al. Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey. Arch Pediatr Adolesc Med 2010; 157 (8): 821-7.
  2. De Bakker J, Van Capelle F, Janse M et al. Slow conduction in the infracted human heart, “zigzag” course of activation. Circulation 1999; 88 (3): 915-26.
  3. EGIR definition of metabolic syndrome. Diabet Med 2002; 16: 442-3.
  4. Rasouli N, Kern P.A. Adipocytokines and the metabolic complications of obesity rasouli and kern. J Clin Endocrinol Metab 2008; 93: 64-73.
  5. Beltowski J. Leptin and atherosclerosis. Atherosclerosis 2006; 189: 47-60.
  6. Wannamethee S.G et al. Adipokines and risk of type 2 diabetes in older men. Diabet Care 2007; 30: 1200-5.
  7. Grundy S.M, Cleeman J.I, Daniels S.R et al. Diagnosis and management of the metabolic syndrome: an American Heart Association. National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2007; 112 (17): 2735-52.
  8. Guzder R.N, Gatling W, Mullee M.A, Byrne C.D. Impact of metabolic syndrome criteria on cardiovascular disease risk in people with newly diagnosed type 2 diabetes. Diabetologia 2006; 49 (10): 49-55.
  9. Savage D.B, Petersen K.F, Shulman G.I. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension 2005; 45 (5): 828-33.
  10. Sattar N, Gaw A, Scherbakova O et al. Metabolic syndrome with and without C-reactive protein as a predictor of coronary heart disease and diabetes in the West of Scotland Coronary Prevention Study. Circulation 2003; 108 (4): 414-9.
  11. Оганов Р.Г., Мамедов М.Н. Школа по диагностике и лечению метаболического синдрома. М.: Медицинская книга, 2007.
  12. Chen Y.H, Lin S.J, Lin F.Y et al. High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide - related but not oxidative stress - mediated mechanisms. Diabetes 2007; 56: 1559-68.
  13. Shaw L.J, Marwick T.H, Zoghbi W.A et al. Why all the focus on cardiac imaging? [Editorial]. JACC Cardiovasc Imaging 2010; 3: 789-94. [PMID: 20633864]; 92 (5): 650-7.
  14. Dandona P, Aljada A, Chaudhuri A. et al. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005; 111 (11): 1448-54.
  15. Chandran M, Phillips S.A, Ciaraldi T, Henry R.R. Adiponectin: more than just another fat cell hormone? Diabetes Care 2003; 26 (8): 2442-50.
  16. Vyssoulis G, Karpanou E, Adamopoulos D et al. Metabolic syndrome in patients with essential hypertension. Hypertension Unit, 1st Cardiology Department, Hippokration Hospital, Athens Medical School, Greece. Nutr Metab Cardiovasc Dis 2013; 23 (2): 109-14. doi: 10.1016/j.numecd.2011.03.011.
  17. Ghosh S, Karin M. Missing pieces in the NF-kappa-B puzzle. Cell 2002; 109 (Suppl.): S81-96.
  18. Yamauchi T, Kamon J, Ito Y et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003; 423 (6941): 762-9.
  19. Группа экспертов Всероссийского научного общества кардиологов. Рекомендации экспертов Всероссийского научного общества кардиологов по диагностике и лечению метаболического синдрома. Второй пересмотр. 2009. http://www.cardiosite.ru/recommendations/article
  20. Маколкин В.И. и др. Необходимость гликемического контроля при лечении метаболического синдрома. Consillium Мedicum. 2007; 9 (5): 58-62.

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