The effect of mood disorders on the course of coronary heart disease: a modern model of pathogenesis of depression, pathophysiological and behavioral patterns

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Abstract

The prevalence of depressive disorders at the population level is from 2,5 to 10% among patients with coronary heart disease - 20%. The presence of depressive disorders in patients with coronary artery disease leads to hypersympathicotonia decrease vagal activity, endothelial dysfunction and blood coagulation system, weighing down the disease. The most significant theories of pathophysiological mechanism of increased mortality in patients with cardiovascular disease in combination with mood disorders are increased thrombus formation and disturbance of the autonomic regulation of heart rhythm.

About the authors

T. G Nonka

Cardiology Research Institute, Siberian Branch of the Academy of Medical Sciences, Tomsk

Email: ntg@sibmail.com
канд. мед. наук, мл. науч. сотр., врач-кардиолог отд-ния реабилитации больных с сердечно-сосудистыми заболеваниями

A. N Repin

Cardiology Research Institute, Siberian Branch of the Academy of Medical Sciences, Tomsk

Email: ran@cardio-tomsk.ru
д-р мед. наук, проф., рук. отд-ния реабилитации больных с сердечно-сосудистыми заболеваниями

T. N Sergienko

Cardiology Research Institute, Siberian Branch of the Academy of Medical Sciences, Tomsk

Email: orb3@cardio.tsu.ru
канд. мед. наук, науч. сотр. отд-ния реабилитации больных с сердечно-сосудистыми заболеваниями

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