Exercise training and endothelial dysfunction

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Abstract

Recent epidemiological studies have shown that lifestyle modification such as aerobic exercise reduces the incidence of cardiovascular morbidity and mortality in the general population. But still poorly understood mechanisms underlying the antiatherogenic and anti-hypertensive effects of physical training. Hypertension is associated with impaired endothelial function, which is mediated by a decrease in the bioavailability of nitric oxide (NO). In animals with simulated hypertension and in people with essential hypertension exercise had been shown to improve endothelial function. This suggests that hypertension, as well as endothelial dysfunction is reversible. It is assumed that changes in lifestyle, including physical exercise, prevent cardiovascular complications by improving endothelial function in patients with hypertension. It is believed that exercise increase the synthesis of NO and reduce levels of inactivation, which results in increased bioavailability of NO. This review presents the potential mechanisms that underlie the positive effect of training on endothelial function in patients with hypertension.

About the authors

S. A Pomeshkina

Research Institute for Complex Problems of cardiovascular diseases, Kemerovo

Email: рomesa@cardio.kem.ru
канд. мед. наук, зав. лаб. реабилитации

References

  1. Mudau M, Genis A, Lochner A, Strijdom H. Endothelial dysfunction: the early predictor of atherosclerosis. Cardiovasc J Afr 2012; 23 (4): 222-31.
  2. Whelton S.P, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: a meta - analysis of randomized, controlled trials. Ann Intern Med 2002; 136: 493-503.
  3. Mora S, Lee I.M, Buring J.E, Ridker P.M. Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women. JAMA 2006; 295: 1412-9.
  4. Gayda M, Brun C, Juneau M et al. Long - term cardiac rehabilitation and exercise training programs improve metabolic parameters in metabolic syndrome patients with and without coronary heart disease. Nutr Metab Cardiovasc Dis 2008; 18 (2): 142-51.
  5. Tambalis K, Panagiotakos D.B, Kavouras S.A, Sidossis L.S. Responses of blood lipids to aerobic, resistance, and combined aerobic with resistance exercise training: a systematic review of current evidence. Angiology 2009; 60 (5): 614-32.
  6. Wang J.S. Exercise and thrombogenesis. J Biomed Sci 2006; 13: 753-61.
  7. Evrengul H, Seleci D, Tanriverdi H, Kaftan A. The antiarrhythmic effect and clinical consequences of ischemic preconditioning. Coron Artery Dis 2006; 17: 283-8.
  8. Taylor R.S, Brown A, Ebrahim S et al. Exercise - based rehabilitation for patients with coronary heart disease: systematic review and meta - analysis of randomized trials. Am J Med 2004; 116: 682-97.
  9. Mc Allister R.M, Laughlin M.H. Vascular nitric oxide: effects of physical activity, importance for health. Essays Biochem 2006; 42: 119-31.
  10. Griffin K.L, Woodman C.R, Price E.M et al. Endothelium - mediated relaxation of porcine collateral - dependent arterioles is improved by exercise training. Circulation 2001; 104 (12): 1393-8.
  11. Sessa W.C, Pritchard K, Seyedi N et al. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res 1994; 74: 349-53.
  12. Goto C, Nishioka K, Umemura T et al. Acute moderate - intensity exercise induces vasodilation through an increase in nitric oxide bioavailiability in humans. Am J Hypertens 2007; 20 (8): 825-30.
  13. Higashi Y, Sasaki S, Kurisu S et al. Regular aerobic exercise augments endothelium - dependent vascular relaxation in normotensive as well as hypertensive subjects: role of endothelium - derived nitric oxide. Circulation 1999; 100: 1194-202.
  14. Uematsu M, Ohara Y, Navas J.P et al. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol 1995; 269: C1371-C1378.
  15. Hudlicka O, Brown M, Egginton S. Angiogenesis in skeletal and cardiac muscle. Physiol Rev 1992; 72: 369-417.
  16. Lloyd P.G, Prior B.M, Yang H.T, Terjung R..L. Angiogenic growth factor expression in rat skeletal muscle in response to exercise training. Am J Physiol Heart Circ Physiol 2003; 284: H1668-H1678.
  17. Gavin T.P, Robinson C.B, Yeager R.C et al. Angiogenesis growth factor response to acute systemic exercise in human skeletal muscle. J Appl Physiol 2003; 96: 19-24.
  18. Fontana J, Fulton D, Chen Y et al. Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Aktdependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res 2002; 90: 866-73.
  19. Olfert I.M, Breen E.C, Mathieu-Costello O, Wagner P.D. Skeletal muscle capillarity and angiogenic mRNA levels after exercise training in normoxia and chronic hypoxia. J Appl Physiol 2001; 91: 1176-84.
  20. Lönna M.E, Dennis J.M, Stocker R. Actions of «antioxidants» in the protection against atherosclerosis. Free Radic Biol Med 2012; 53 (4): 863-84.
  21. Davis M.E, Cai H, Mc Cann L et al. Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training.Am J Physiol Heart Circ Physiol 2003; 284: H1449-H1453.
  22. Matsumoto A, Hirata Y, Momomura S et al. Increased nitric oxide production during exercise. Lancet 1994; 343: 849-50.
  23. Rush J.W, Turk J.R, Laughlin M.H. Exercise training regulates SOD-1 and oxidative stress in porcine aortic endothelium. Am J Physiol Heart Circ Physiol 2003; 284: H1378-H1387.
  24. Higashi Y, Sasaki S, Nakagawa K et al. Endothelial function and oxidative stress in renovascular hypertension. N Engl J Med 2002; 346: 1954-62.
  25. Van Guilder G.P, Westby C.M, Greiner J.J et al. Endothelin-1 vasoconstrictor tone increases with age in healthy men but can be reduced by regular aerobic exercise. Hypertension 2007; 50 (2): 403-9.
  26. Maeda S, Miyauchi T, Kakiyama T et al. Effects of exercise training of 8 weeks and detraining on plasma levels of endothelium - derived factors, endothelin-1 and nitric oxide, in healthy young humans. Life Sci 2001; 69: 1005-16.
  27. Lavrencic A, Salobir B.G, Keber I. Physical training improves flowmediated dilation in patients with the polymetabolic syndrome. Arterioscler Thromb Vasc Bio 2000; 20: 551-5.
  28. Griffin K.L, Laughlin M.H, Parker J.L. Exercise training improves endothelium - mediated vasorelaxation after chronic coronary occlusion. J Appl Physiol 1999; 87: 1948-56.
  29. Yen M.H, Tang J.H, Sheu J.R et al. Chronic exercise enhances endothelium - mediated dilation in spontaneously hypertensive rats. Life Sci 1995; 57: 2205-13.
  30. Willson J.R, Kapoor S.C. Contribution of prostaglandins to exercise - induced vasodilation in humans. Am J Physiol 1993; 265: H171-H175.

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