目前对间位骨骺骨髓炎的理解。文献综述

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本文回顾了国内外关于幼儿间位骨骺骨髓炎的诊断和治疗、免疫系统及其细胞因子成分的变化特点以及对由此导致的疾病的针对性纠正的文献。该研究的目的是说明目前诊断和治疗幼儿间位骨骺骨髓炎的方法。把重点放在病人免疫状态的变化上。

在俄语的eLibrary.ru和英语的Medline、Web of Science和PubMed数据库中进行了文献检索。 检索的关键词是：“метаэпифизарный остеомиелит”: “дети раннего возраста”、“иммунная система”、“цитокины”、 “интерлейкины”、 “ронколейкин”（metaepiphyseal osteomyelitis/骨骺线骨髓炎、infants/婴儿、immune system/免疫系统、cytokines/细胞因子、interleukins/白细胞介素、roncoleukin）。总共发现了405篇出版物，其中66篇与本研究的目的完全一致。对它们进行了分析。

出版物中的数据表明，寻找早期诊断幼儿骨髓炎的有效方法仍然是有意义的。所审查的方法中没有一种能完整地反映出病理过程的严重性。众多的研究在评估免疫系统、其细胞因子成分的变化和间位骨骺骨髓炎发展的意义方面缺乏统一的看法。出版物中的数据显示，使用重组人白介素-2对一些幼儿疾病的综合治疗起着积极作用。幼儿间位骨骺骨髓炎是儿童外科学的一个紧迫问题。这主要是由于免疫生物学反应性降低的儿童人数越来越多。这种病理需要在对病人进行综合的病因和病理治疗时使用有效的免疫纠正方法。这主要包括用于重组细胞因子制剂等强大的免疫调节剂。

作者简介

Vadim V. Grishaev

Samarkand State Medical University; GUZ "Odoevskaya Central District Hospital named after P.P.Belousov"

Email: vadim_grishaev@rambler.ru
ORCID iD: 0000-0001-5806-2421
SPIN 代码: 9847-3236

pediatrician

乌兹别克斯坦, Samarkand; Odoev, Tula region, Russia

Azamat M. Shamsiev

Samarkand State Medical University

编辑信件的主要联系方式.
Email: a-shamsiev@mail.ru
ORCID iD: 0000-0001-8482-7037

Dr. Sci. (Med.), professor of the Department of Pediatric Surgery No. 1

乌兹别克斯坦, Samarkand

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