Chemical pleurodesis using povidon-iodine for chylothorax treatment in newborns
- Authors: Kozlov Y.A.1,2,3, Rasputin A.A.1, Kovalkov K.A.4, Poloyan S.S.5, Baradieva P.Z.1, Zvonkov D.A.1, Ochirov C.B.1, Cheremnov V.S.1, Kapuller V.M.6
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Affiliations:
- Irkutsk Municipal Pediatric Clinical Hospital
- Irkutsk State Medical Academy of Postgraduate Education
- Irkutsk State Medical University
- Children’s City Clinical Hospital
- Center for Maternity and Infancy
- Assuta University Medical Center, Ben Gurion University
- Issue: Vol 10, No 4 (2020)
- Pages: 391-399
- Section: Original Study Articles
- URL: https://journals.rcsi.science/2219-4061/article/view/122936
- DOI: https://doi.org/10.17816/psaic707
- ID: 122936
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Abstract
Introduction. Chylothorax is a rare condition that results from abnormal accumulation of lymphatic fluid in the chest and one of the most common causes of pleural effusion in newborns. The aim of our study is to present our own experience of chemical pleurodesis using povidone-iodine in newborns with chylothorax.
Materials and methods. In the present study, we studied data from 10 patients with chylothorax who, over the past years, starting in 2016, underwent chemical pleurodesis using the drug povidone-iodine. Congenital accumulation of lymph in the pleural cavity was recorded in 2 patients, acquired — in 8 patients. The indications for this procedure were the absence of response to total parenteral nutrition for at least 10 days and the appointment of octreotide at the maximum dosage. Pleurodesis consisted in the introduction into the pleural cavity of a 4% solution of povidone-iodine with a calculated dose of 1 ml/kg. The povidone-iodine solution was kept inside the pleural cavity for the next 4 hours.
Results. Chemical pleurodesis was successfully applied in all 10 patients. In 8 patients, a single prescription of the drug was sufficient, and in 2 remaining patients, the pleurodesis session was repeated. After the procedure of chemical pleurodesis, 2 patients developed respiratory distress syndrome caused by massive atelectasis of the homolateral lung, which was confirmed by X-ray examination. These patients required mechanical ventilation for 24 and 48 hours. The average time for the disappearance of chylothorax was 4 days. In the long-term follow-up, 1 patient died from progressive deterioration of pulmonary function against the background of lung hypoplasia.
Conclusions. Our data demonstrate that povidone iodine pleurodesis is a effective treatment for chylothorax in newborns.
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##article.viewOnOriginalSite##About the authors
Yury A. Kozlov
Irkutsk Municipal Pediatric Clinical Hospital; Irkutsk State Medical Academy of Postgraduate Education; Irkutsk State Medical University
Email: yuriherz@hotmail.com
ORCID iD: 0000-0003-2313-897X
Head of Department of neonatal surgery, Irkutsk Municipal Pediatric Clinical Hospital, professor of the Department of pediatric surgery, Irkutsk State Medical University Russia, professor of the Department of pediatric surgery, Irkutsk State Medical Academy of Continuing Education
Russian Federation, Irkutsk; Irkutsk; IrkutskAndrey A. Rasputin
Irkutsk Municipal Pediatric Clinical Hospital
Email: arasputin@mail.ru
ORCID iD: 0000-0002-5690-790X
surgeon of department of neonatal surgery
Russian Federation, IrkutskKonstantin A. Kovalkov
Children’s City Clinical Hospital
Email: gs-det-hirurg@kuzdrav.ru
ORCID iD: 0000-0001-6126-4198
Cand. Sci. (Med.), Head of pediatric surgery
Russian Federation, KemerovoSimon S. Poloyan
Center for Maternity and Infancy
Author for correspondence.
Email: kkkc@pericentr.ru
ORCID iD: 0000-0001-7042-6646
pediatric surgeon
Russian Federation, KrasnoyarskPolina Z. Baradieva
Irkutsk Municipal Pediatric Clinical Hospital
Email: p.baradieva@icloud.com
ORCID iD: 0000-0002-5463-6763
surgeon of department of neonatal surgery
Russian Federation, IrkutskDenis A. Zvonkov
Irkutsk Municipal Pediatric Clinical Hospital
Email: Denis.Zvonkov@mail.ru
ORCID iD: 0000-0002-7167-2520
pediatric surgeon
Russian Federation, IrkutskChimit B. Ochirov
Irkutsk Municipal Pediatric Clinical Hospital
Email: chimitbator@gmail.com
ORCID iD: 0000-0002-6045-1087
Surgeon of Department of neonatal surgery
Russian Federation, IrkutskVladislav S. Cheremnov
Irkutsk Municipal Pediatric Clinical Hospital
Email: chervl@mail.ru
ORCID iD: 0000-0001-6135-4054
Surgeon of Department of neonatal surgery
Russian Federation, IrkutskVadim M. Kapuller
Assuta University Medical Center, Ben Gurion University
Email: ru-office@hadassah.org.il
ORCID iD: 0000-0003-0076-5778
surgeon in Hadassah University Medical Center
Israel, Ashdod