Prophylaxis of rhesus-sensitization of pregnant women. Experience of anti-rhesus immunoglobulin Rhesogam® N using

Cover Page

Cite item

Full Text

Abstract

Aim. Retrospective assessment of the efficiency and safety of the anti-rhesus Rh (D) immunoglobulin Rhesogam® N in preventing isoimmunization in Rh-negative women during pregnancy.

Materials and methods. An analysis of medical records of 196 Rh-negative patients who received anti-Rh immunoglobulin Rhesogam® N in the period 2019–2021 was performed. The indications for the drug were the aspiration of chorionic villi, amniocentesis and prenatal prophylaxis in women with negative level of anti-Rh antibodies and in the case of Rh-positive husbands.

Results. In total, 227 doses of the anti-rhesus immunoglobulin Rhesogam® N were administered, including those women who underwent invasive procedures (aspiration of chorionic villi, amniocentesis). There were no adverse events, including anaphylaxis or drug-related events. 172 rhesus-positive babies were born. No cases of hemolityc disease of the newborns were reported. Anti-Rh antibodies were not found in their mothers after childbirth.

Conclusion. The study confirmed the efficacy and safety of the antiresus Rh (D) immunoglobulin Rhesogam® N for the prevention of Rh isoimmunization.

About the authors

Nail R. Nuriev

Kazan Medical Diagnostic Center “Nurievs Clinic”

Author for correspondence.
Email: nnplus@mail.ru
ORCID iD: 0000-0002-7971-6831

reproductive physician, Chief doctor

Russian Federation, Kazan

Rushania I. Gabidullina

Kazan State Medical University

Email: ru.gabidullina@yandex.ru
ORCID iD: 0000-0002-7567-6043

D. Sci. (Med.)

Russian Federation, Kazan

Diana I. Galautdinova

Kazan Medical Diagnostic Center “Nurievs Clinic”

Email: diana_gi@mail.ru
ORCID iD: 0000-0002-6204-9550

obstetrician-gynecologist

Russian Federation, Kazan

References

  1. Chauhan AR, Nandanwar YS, Ramaiah A, et al. A Multicenter, Randomized, Open-Label Trial Comparing the Efficacy and Safety of Monoclonal Anti-Rh (D) Immunoglobulin with Polyclonal Anti-Rh (D) Immunoglobulin for the Prevention of Maternal Rh-Isoimmunization. J Obstet Gynaecol India. 2019;69(5):420-5. doi: 10.1007/s13224-019-01234-2
  2. McBain RD, Crowther CA, Middleton P; Cochrane Pregnancy and Childbirth Group. Anti-D administration in pregnancy for preventing Rhesus alloimmunisation. Cochrane Database Syst Rev. 2015;2015(9):CD000020. doi: 10.1002/14651858.CD000020.pub3
  3. Прищепенко О.А., Потапова В.Е., Лысенко И.М. Патогенетические основы лечения гемолитической болезни новорожденного. Охрана материнства и детства. 2021;1(37):86-92 [Prischepenko OA, Potapova VE, Lysenko IM. Pathogenetic foundations of treatment of neonatal hemolytic disease. Ohrana materinstva i detstva. 2021;1(37):86-92 (in Russian)].
  4. Устьянцева Н.Ю., Путилова Н.В., Чистякова Г.Н. Современные подходы к диагностике и терапии резус-сенсибилизации. Лечение и профилактика. 2020;10(2):89-94 [Ustyanceva NYu, Putilova NV, Chistyakova GN. Modern approaches to the diagnosis and therapy of rh sensitization. The journal of disease treatment and prevention. 2020;10(2):89-94 (in Russian)].
  5. De Haas M, Thurik FF, Van der Ploeg CP, et al. Sensitivity of fetal RHD screening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the Netherlands. BMJ. 2016;7(355):i5789. doi: 10.1136/bmj.i5789
  6. Pilgrim H, Lloyd-Jones M, Rees A. Routine antenatal anti-D prophylaxis for Rh D negative women: a systematic review and economic evaluation. Health Technol Assess. 2009;13(10):iii, ix-xi, 1-103. doi: 10.3310/hta13100
  7. Costumbrado J, Mansour T, Ghassemzadeh S. Rh Incompatibility. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing, 2018. Available at: https://www.ncbi.nlm.nih.gov/books/NBK459353. Accessed: 27.08.2021.
  8. Stucki M, Moudry R, Kempf C, et al. Characterisation of a chromatographically produced anti-D immunoglobulin product. J Chromatogr B Biomed Sci Appl. 1997;700(1-2):241-8. doi: 10.1016/s0378-4347(97)00319-8
  9. Bichler J, Schondorfer G, Pabst G, Andresen I. Pharmacokinetics of anti-D IgG in pregnant RhD-negative women. BJOG. 2003;110:39-45.
  10. Miescher S, Spycher MO, Amstutz H, et al. A single recombinant anti-RhD IgG prevents RhD immunization: association of RhD-positive red blood cell clearance rate with polymorphisms in the FcyRIIA genes and FcylllA genes. Blood. 2004;103(11):4028-35. doi: 10.1182/blood-2003-11-3929
  11. Резус-сенсибилизация. Гемолитическая болезнь плода. Клинические рекомендации (протокол). М., 2017, 2020 [Rezus-sensibilizatsiia. Gemoliticheskaia bolezn' ploda. Klinicheskie rekomendatsii (protokol). Moscow, 2017, 2020 (in Russian)].
  12. Olovnikova N. Anti-RhD-mediated immunosuppression: can monoclonal antibodies imitate the action of polyclonal antibodies? In: Immunosuppression-role in health and diseases. InTech, 2012. doi: 10.5772/28744
  13. Фаткуллин И.Ф., Субханкулова А.Ф., Мунавирова А.А. Плюс на минус – все равно минус. Профилактика иммуноконфликтной беременности: проблемы и перспективы. Status praesens. 2016,3(32):25-35 [Fatkullin IF, Subhankulova AF, Munavirova AA. Plius na minus – vse ravno minus. Profilaktika immunokonfliktnoi beremennosti: problemy i perspektivy. Status praesens. 2016;3(32):25-35 (in Russian)].
  14. Куклина Л.В., Ожерельева М.А., Мещенкова Е.Ф. Профилактика резус-иммунизации у беременных с потенциально сенсибилизирующими событиями. Бюллетень медицинской науки. 2017;3(7):32-5 [Kuklina LV, Ozherel'eva MA, Meshchenkova EF. Profilaktika rezus-immunizatsii u beremennykh s potentsial'no sensibiliziruiushchimi sobytiiami. Bulletin of medical science. 2017;3(7):32-5 (in Russian)].
  15. Al-Mufti R, Hambley H, Farzaneh F, Nicolaides KH. Distribution of fetal erythroblasts in maternal blood after chorionic villous sampling. BJOG. 2003;110:33-8.
  16. Freda VJ, Gorman J, Pollack W. Successful prevention of experimental Rh sensitization in man with anti-Rh Gamma2-globulin antibody preparation: a preliminary report. Transfusion. 1964;4:26-32. doi: 10.1111/j.1537-2995.1964.tb02824.x
  17. MacKenzie IZ, Bichler J, Mason GC, et al. Efficacy and safety of a new, chromatographically purified rhesus (D) immunoglobulin. Eur J Obstet Gynecol Reprod Biol. 2004;117(2):154-61. doi: 10.1016/j.ejogrb.2004.03.009

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2021 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).