Risk factors for the threat of termination of pregnancy in women with recurrent miscarriage: a suvey-based study

Background. Habitual miscarriage remains an urgent problem of modern obstetrics and does not tend to decrease.

Aim. To identify risk factors for the threat of abortion in the first trimester in women with recurrent miscarriage.

Materials and methods. A survey of 353 pregnant women at a gestational age of 5–12 weeks was carried out. The main group consisted of 111 women with signs of the threat of termination at the time of examination and recurrent miscarriage. The control group consisted of 242 women with uncomplicated pregnancy without recurrent miscarriage. Each patient was monitored throughout pregnancy and the postpartum period, the condition of the newborn was assessed according to the medical documentation of the pediatric departments. Statistical data processing was carried out using standard licensed programs Microsoft Excel 2007, the calculation of the odds ratio of risk factors was carried out using the OpenEpi system.

Results. We identified the following risk factors for termination of pregnancy in women with recurrent miscarriage: the age of women over 30; alimentary factors – insufficient consumption of meat, eggs, while more frequent use of alcoholic beverages; burdened obstetric and gynecological history: acute/chronic endometritis, endometriosis; the presence of surgical interventions on the pelvic organs in the history of infertility, ectopic pregnancy, anomalies in the development of the genital organs; the presence of extragenital diseases and their combinations, in particular, thyroid disease.

Conclusion. With the timely identification of significant risk factors, it becomes possible to carry out measures aimed at correcting controllable factors, careful pregravid preparation in order to improve the perinatal outcomes of future pregnancy.