Possibilities of preservation and realization of reproductive function in girls with Turner syndrome (analytical review)

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Abstract

Turner syndrome (TS) is the most common chromosomal abnormality in females. TS is associated with partial or complete loss of the second X-chromosome in phenotypic females and is associated with increased morbidity and mortality. There are many controversial issues of monitoring, management and counseling of patients with TS. This review emphasizes the need for a multidisciplinary approach to the study of this pathology to enable the realization of reproductive function in patients with TS.

About the authors

Z Kh Kumykova

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: zai-kumykova@yandex.ru
канд. мед. наук, ст. науч. сотр. 2-го гинекологического отд-ния (гинекологии детского и юношеского возраста) 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

Z K Batyrova

V.I.Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: linadoctor@mail.ru
канд. мед. наук, науч. сотр. 2-го гинекологического отд-ния (гинекологии детского и юношеского возраста) 117997, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

References

  1. Reynaud K, Cortvrindt R, Verlinde F et al. Number of ovarian follicles in human fetuses with the 45,X karyotype. Fertility Steril 2004; 81 (4): 1112-9.
  2. Castronovo C, Rossetti R, Rusconi D et al. Gene dosage as a relevant mechanism contributing to the determination of ovarian function in Turner syndrome. Human Reprod 2014; 29 (2): 368-79.
  3. Aso K, Koto S, Higuchi A et al. Serum FSH level below 10 mIU/mL at twelve years old is an index of spontaneous and cyclical menstruation in Turner syndrome. Endocrine J 2010; 57 (10): 909-13.
  4. Visser J.A, Hokken-Koelega A.C, Zandwijken G.R et al. Anti-Mullerian hormone levels in girls and adolescents with Turner syndrome are related to karyotype, pubertal development and growth hormone treatment. Human Reprod 2013; 28: 1899-907.
  5. Bondy C.A. Care of girls and women with turner syndrome: a guideline of the turner syndrome study group. J Clin Endocrinol Metab 2007; 9: 10-25.
  6. Gravholt C.H. Clinical practice in Turner syndrome. Nat Clin Pract Endocrinol Metab 2005; 1 (1): 41-52.
  7. Schoemaker M.J, Swerdlow A.J, Higgins C.D et al. United Kingdom Clinical Cytogenetics G. Mortality in women with turner syndrome in Great Britain: a national cohort study. J Clin Endocrinol Metab 2008; 93 (12): 4735-42.
  8. Oliveira R.M, Verreschi I.T, Lipay M.V et al. Y chromosome in Turner syndrome: review of the literature. Sao Paulo Med J 2009; 127 (6): 373-8.
  9. Курьянова Ю.Н., Уварова Е.В. Молекулярно-генетические основы синдрома Тернера. Клиническое значение тканевого мозаицизма в выборе тактики обследования и лечения больных. Репродуктивное здоровье детей и подростков. 2013; 1: 67-84.
  10. Trolle C, Hjerrild B, Cleemann L et al. Sex hormone replacement in Turner syndrome. Endocrine 2012; 41: 200-19.
  11. Davenport M.L. Moving toward an understanding of hormone replacement therapy in adolescent girls: looking through the lens of Turner syndrome. Ann NY Acad Sci 2008; 1135: 126-37.
  12. Courant F, Aksglaede L, Antignac J.P et al. Assesment of circulation sex steroid levels in prepubertal and pubertal boys and girls by a novel ultrasensitive gas chromatography-tandem mass spectrometry method. J Clin Endocrinol Metab 2010; 95: 82-92.
  13. Oktay K, Bedoschi G, Berkowitz K et al. Fertility preservation in women with turner syndrome: a comprehensive review and practical guidelines. J Ped Adolescent Gynecol 2016; 29: 409-16.
  14. Quigley C.A, Wan X, Garg S et al. Effects of low-dose estrogen replacement during childhood on pubertal development and gonadotropin concentration in patients with Turner Syndrome: results of a randomized, double-blind, placebo-controlled clinical trial. J Clin Endocrinol Metab 2014; 99: 1754-64.
  15. Ross J.L, Quigley C.A, Cao D et al. Growth hormone plus childhood low-dose estrogen in Turner`s syndrome. N Eng J Med 2011; 354: 1230-42.
  16. Chevalier N, Letur H, Lelannou D et al. French Study Group for Oocyte Donation. Materno-fetal cardiovascular complications in Turner syndrome after oocyte donation: insufficient prepregnancy screening and pregnancy follow-up are associated with poor outcome. J Clin Endocrinol Metab 2011; 96 (2): E260-7.
  17. Hagman A, Loft A, Wennerholm U.B et al. Obstetric and neonatal outcome after oocyte donation in 106 women with Turner syndrome: a Nordic cohort study. Hum Reprod 2013; 28: 1598-609.
  18. Bryman I, Lisskulla S, Kerstin B et al. Pregnancy rate and outcome in Swedish women with Turner syndrome. Fertil Steril 2011; 95 (8): 2507-10.
  19. Hovatta O. Ovarian function and in vitro fertilization (IVF) in Turner syndrome. Pediatr Endocrinol Rev 2012; 9 (2): 713-7.
  20. Hadnott T.N, Gould H.N, Gharib A.M, Bondy C.A. Outcomes of spontaneous and assisted pregnancies in Turner syndrome: the U.S. National Institutes of Health experience. Fertil Steril 2011; 95 (7): 2251-6.
  21. Bernard V, Donadille B, Zenaty D et al. Spontaneous fertility and pregnancy outcomes amongst 480 women with Turner syndrome. Hum Reprod 2016; 31: 782-8.

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