To the question about diagnostics, prevention and therapy of pathology of the cervix

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Abstract

The review analyzes the latest American clinical guidelines on the effectiveness of cervical cancer screening programs, as well as references on the use of the immunomodulator isoprinosine for the treatment of patients infected with the human papilloma virus (HPV). The high prevalence of HPV and its role in the development of cervical cancer are shown. Isoprinosine belongs to immunomodulators with antiviral activity. It inhibits the replication of viral DNA and RNA by binding to cell ribosomes and changing their stereochemical structure. HPV infection, especially in the early stages, may be successfully cured till the complete elimination of the virus. Inosine Pranobex (Izoprinozin) having dual action and the most abundant evidence base, may be recognized as the optimal treatment option.

About the authors

S O Dubrovina

Rostov State Medical University of the Ministry of Health of the Russian Federation; Rostov Research Institute of Obstetrics and Pediatrics of the Ministry of Health of the Russian Federation

Email: s.dubrovina@gmail.com
д-р мед. наук, проф., гл. науч. сотр. 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29

O A Ardintseva

Rostov State Medical University of the Ministry of Health of the Russian Federation

аспирант 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29

L V Krasilnikova

Medical Center "DA VINCI"

канд. мед. наук, врач акушер-гинеколог 344091, Russian Federation, Rostov-on-Don, ul. Tolmacheva, d. 117

M V Varicheva

Clinical Hospital №20 of Rostov-on-Don

врач акушер-гинеколог гинекологического отделения 344091, Russian Federation, Rostov-on-Don, pr. Kommunisticheskiy, d. 39

O A Afrikyan

Rostov State Medical University of the Ministry of Health of the Russian Federation

студент 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29

References

  1. Bruni L, Barrionuevo-Rosas L, Albero G et al. WHO/ICO Information Centre on HPV and Cancer. Russian Federation: Human Papillomavirus and Related Cancers, Fact Sheet 2017 (October 7, 2016).
  2. National Cancer Institute (NCI). Cancer Stat Facts: cervical cancer. NCI website. https://seer.cancer.gov/statfacts/html/cervix.html. This link goes offsite. Click to read the external link disclaimer. Accessed June 28, 2018.
  3. Melnikow J, Henderson J.T, Burda B.U et al. Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force. JAMA 2018; 320 (7): 687-705. doi: 10.1001/jama.2018.10400
  4. Benard V.B, Watson M, Castle P.E, Saraiya M. Cervical carcinoma rates among young females in the United States. Obstet Gynecol 2012; 120 (5): 1117-23. DOI: http: //10.1097/AOG.0b013e31826e4609
  5. Kim J.J, Burger E.A, Regan C, Sy S. Screening for Cervical Cancer in Primary Care: A Decision Analysis for the U.S. Preventive Services Task Force [Internet]. Rockville, MD: Agency for Healthcare Research and Quality (US); 2018 Aug. U.S. Preventive Services Task Force Evidence Syntheses, formerly Systematic Evidence Reviews.
  6. Melnikow J, Henderson J.T, Burda B.U et al. Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: A Systematic Evidence Review for the US Preventive Services Task Force: Evidence Synthesis No. 158. Rockville, MD: Agency for Healthcare Research and Quality; 2018. AHRQ publication 15-05224-EF-1.
  7. Кедрова А.Г., Леваков С.А., Челнокова Н.Н. Оптимизация медикаментозной терапии начальных повреждений эпителия шейки матки, ассоциированных с вирусом папилломы человека. Акуш. и гинекол. 2014; 8.
  8. Шейка матки, влагалище, вульва. Физиология, патология, кольпоскопия, эстетическая коррекция. Под ред. С.И.Роговской, Е.В.Липовой. М.: StatusPraesence, 2014. [in Russian]
  9. Amador-Molina A, Hernández-Valencia JF, Lamoyi E et al. Role of innate immunity against human papillomavirus (HPV) infections and effect of adjuvants in promoting specific immune response. Viruses 2013; 5 (11): 2624-42. doi: 10.3390/v5112624
  10. Инструкция по медицинскому применению лекарственного препарата Изопринозин. / Instruktsiia po meditsinskomu primeneniiu lekarstvennogo preparata Izoprinozin. [in Russian]
  11. Кисина В.И., Воробьев П.А. Протоколы ведения больных. Инфекции, передаваемые половым путем. М.: Ньюдиамед, 2011
  12. Berek J, Novak E. Berek and Novak’s Gynecology, 14th ed. Philadelphia: Lippincott Williams & Wilkins, 2007; p. 548.
  13. Hafez E.S, Kenemans P. Atlas of Human Reproduction By Scanning Electron Microscopy. Springer Science & Business Media, 2012.
  14. Hillery A.M, Park K. Drug Delivery: Fundamentals and Applications, Second Edition. CRC Press, 2016.
  15. Роговская С.И. Практическая кольпоскопия. М.: ГЭОТАР-Медиа, 2016.
  16. Sadoul G, Beuret T. Treatment of cervical and vulvar condyloma with CO2 laser combined with an immunostimulant [in French]. Rev Franais Gynecol Obstet 1984; 79 (11): 681-4.
  17. Кедрова А.Г., Подистов Ю.И., Кузнецов В.В. и др. Роль противовирусной терапии в комплексном лечении больных эпителиальными дисплазиями и преинвазивным раком шейки матки. Гинекология. 2005; 7 (3): 170-3
  18. Роговская С.И., Теребнева Л.И. Клинические аспекты плоскоклеточных интраэпителиальных поражений низкой степени. Акуш. и гинекол. 2013; 2: 139-43

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