The case of ineffective conservative treatment of endometriosis of anterior abdominal wall from the point of view of the possible role of stem cells


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Abstract

The article highlights the pathogenetic mechanisms of endometriosis outside the peritoneal cavity from the point of view of the role of bone marrow stem cells, given a possible explanation for the low efficiency of drug therapy of endometriosis outside the peritoneal cavity. The paper presents our own experience of using agonist of gonadotropin-releasing hormone intrauterine device with levonorgestrel at the same time.

About the authors

S O Dubrovina

Rostov State Medical University of the Ministry of Health of the Russian Federation; Rostov Research Institute of Obstetrics and Pediatrics of the Ministry of Health of the Russian Federation

Email: s.dubrovina@gmail.com
д-р мед. наук, проф. каф. акушерства и гинекологии №1 ФГБОУ ВО РостГМУ, гл. науч. сотр. ФГБУ РНИИАП 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29; 344012, Russian Federation, Rostov-on-Don, ul. Mechnikova, d. 43

Yu D Berlim

Rostov State Medical University of the Ministry of Health of the Russian Federation

Email: juliaberlim@yandex.ru
канд. мед. наук, врач гинекологического отд-ния клиники ФГБОУ ВО РостГМУ 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29

V S Gimbut

Rostov Research Institute of Obstetrics and Pediatrics of the Ministry of Health of the Russian Federation

Email: secretary@rniiap.ru
канд. мед. наук, ФГБУ РНИИАП 344012, Russian Federation, Rostov-on-Don, ul. Mechnikova, d. 43

L V Krasilnikova

Rostov State Medical University of the Ministry of Health of the Russian Federation

Email: cool.dalida2014@yandex.ru
аспирантка ФГБОУ ВО РостГМУ 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29

K A Areshyan

Rostov Research Institute of Obstetrics and Pediatrics of the Ministry of Health of the Russian Federation

Email: arieshian@bk.ru
аспирантка ФГБУ РНИИАП 344012, Russian Federation, Rostov-on-Don, ul. Mechnikova, d. 43

A I Lukash

Rostov State Medical University of the Ministry of Health of the Russian Federation

канд. мед. наук, ассистент каф. хирургических болезней №4 ФГБОУ ВО РостГМУ 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29

References

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  2. Taylor H.S, Osteen K.G, Bruner-Tran K.L et al. Novel therapies targeting endometriosis. Reprod Sci 2011; 18 (9): 814-23. doi: 10.1177/1933719111410713.
  3. Duke C.M, Taylor H.S. Stem cells and the reproductive system: historical perspective and future directions. Maturitas 2013; 76 (3): 284-9. doi: 10.1016/j.maturitas.2013.08.012.
  4. Olive D.L. Medical therapy of endometriosis. Semin Reprod Med 2003; 21 (2): 209-22.
  5. Moggio A, Pittatore G, Cassoni P et al. Sorafenib inhibits growth, migration, and angiogenic potential of ectopic endometrial mesenchymal stem cells derived from patients with endometriosis. Fertil Steril 2012; 98 (6): 1521-30.e2. doi: 10.1016/j.fertnstert.2012.08.003.
  6. Sakr S, Naqvi H, Komm B et al. Endometriosis impairs bone marrow - derived stem cell recruitment to the uterus whereas bazedoxifene treatment leads to endometriosis regression and improved uterine stem cell engraftment. Endocrinology 2014; 155 (4): 1489-97. doi: 10.1210/en.2013-1977.
  7. Kulak J.Jr, Fischer C, Komm B, Taylor H.S. Treatment with bazedoxifene, a selective estrogen receptor modulator, causes regression of endometriosis in a mouse model. Endocrinology 2011; 152 (8): 3226-32. doi: 10.1210/en.2010-1010.
  8. Hufnagel D, Li F, Cosar E et al. The Role of Stem Cells in the Etiology and Pathophysiology of Endometriosis. Semin Reprod Med 2015; 33 (5): 333-40. doi: 10.1055/s-0035-1564609.

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