Features of calcium metabolism during pregnancy depending on body saturation of vitamin D


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Objective. The objective of this research was to estimate influence of vitamin D saturation on calcium metabolism in pregnancy. Materials and methods. Cohort retrospective and prospective study. 110 pregnant women (mean age 29,64±2,3 years) at 30-38 weeks of pregnancy were examined. Investigation time lasted from September 2013 to June 2014. All patients had blood sampling done with the following determination of the levels of 25-hydroxycalciferol, calcium, parathyroid hormone. All patients lived in Saint Petersburg and Leningrad region. From 12 gestational week all patients were using a multivitamin complex, which contained 400 IU of vitamin D. Results. 110 pregnant were analyzed. Among all examined pregnant women the normal blood serum level of 25-OH-D was in 49 (44,5%) pregnant, 25-OH-D insufficiency - in 22 (20%) patients, 25-OH-D deficiency - in 39 (35,5%) pregnant. Calcium level in blood serum in pregnant with normal vitamin D saturation was 2,32±0,06 mmol/L, with insufficiency - 2,17±0,03 mmol/L, with vitamin D deficiency - 2,08±0,02 mmol/L Parathyroid hormone levels in blood serum in pregnant with normal vitamin D saturation was 23,63±1,9 pg/ml, with vitamin D deficiency - 31,±2,3 pg/ml. Conclusion. The increase of parathyroid hormone in blood serum occurs during the insufficient saturation of vitamin D in pregnant women. In pregnant with vitamin D deficiency and insufficiency relative hypocalcemia occurs. Received data confirm correlation between body saturation of vitamin D and calcium metabolism during pregnancy.

About the authors

E S Shelepova

V.A.Almazov North-West federal medical research center of the Ministry of Health of the Russian Federation

Email: garbunchik@mail.ru
науч. сотр. НИЛ репродукции и здоровья женщины Института перинатологии и педиатрии ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

I E Zazerskaya

V.A.Almazov North-West federal medical research center of the Ministry of Health of the Russian Federation

д-р мед. наук, зав. каф. акушерства и гинекологии ФГБУ СЗФМИЦ им.В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

E L Chazova

V.A.Almazov North-West federal medical research center of the Ministry of Health of the Russian Federation

науч. сотр. НИЛ репродукции и здоровья женщины Института перинатологии и педиатрии ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

L V Kuznetsova

V.A.Almazov North-West federal medical research center of the Ministry of Health of the Russian Federation

канд. мед. наук, зав. НИЛ репродукции и здоровья женщины Института перинатологии и педиатрии ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

N Yu Yakovleva

V.A.Almazov North-West federal medical research center of the Ministry of Health of the Russian Federation

науч. сотр. НИЛ физиологии и патологии беременности и родов Института перинатологии и педиатрии ФГБУ СЗФМИЦ им. В.А.Алмазова 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

E Yu Vasileva

V.A.Almazov North-West federal medical research center of the Ministry of Health of the Russian Federation

зав. ЦКДЛ ФГБУ СЗФМИЦ им. В.А.Алмазова, ассистент каф. клин. лабораторной диагностики 197341, Russian Federation, Saint Petersburg, ul. Akkuratova, d. 2

References

  1. Hollis B.W, Wagner C.L. Vitamin D requirements during lactation: high - dose maternal supplementation as therapy to prevent hypovitaminosis D for both the mother and the nursing infant. Am J Clin Nutr 2004;80 (Suppl. 6):1752S-8S.
  2. Lee J.M, Smith J.R, Philipp B.L et al. Vitamin D deficiency in a healthy group of mothers and newborn infants. Clin Pediatr (Phila) 2007; 46 (1): 42-4.
  3. Bodnar L.M, Simhan H.N, Powers R.W et al. High prevalence of vitamin D insufficiency in black and white pregnant women residing in the northern United States and their neonates. J Nutr 2007; 137 (2): 447-52.
  4. Dawson-Hughes B, Mithal A, Bonjour J.P et al. IOF position statement: vitamin D recommendations for older adults. Osteoporos Int 2010; 21 (7): 1151-4.
  5. Bischoff-Ferrari H.A, Burckhardt P, Quack-Loetscher K et al. Vitamin D deficiency: Evidence, safety, and recommendations for the Swiss population. Report written by a group of experts on behalf of the Federal Commission for Nutrition (FCN) 2012.
  6. Gómez de Tejada Romero M.J, Sosa Henríquez M, Del Pino Montes J et al. Position document on the requirements and optimum levels of vitamin D. Rev Osteoporos Metab Miner 2011; 3 (1): 53-64.
  7. Singht H.J, Mohammad N.H, Nila A. Serum calcium and parathormone during normal pregnancy in Malay women. J Maternal-Fetal med 1999; 8 (Issue 3): 95-100.
  8. Hollis B.W, Wagner C.L, Drezner M.K, Binkley N.C. Circulating vitamin D3 and 25-hydroxyvitamin D in humans: An important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol 2007; 103 (3-5): 631-4.
  9. Ritchi L.D, King J.C. Dietary calcium and pregnancy induced hypertension: is there a relation? Am J Clin Nutrit 2000; 71 (5): 1371-4.
  10. O' Brien K.O, Nathanson M.S, Mancini J, Witter F.R. Сalcium absorption is significantly higher in adolescents during pregnancy than in early postpartum period. Am J Clin Nutrit 2003; 78 (6): 1188-93.
  11. Абрамченко В.В. Профилактика и лечение нарушений обмена кальция в акушерстве, гинекологии и перинатологии. Спб.: ЭЛБИ, 2006.
  12. Cockburn F et al. Maternal vitamin D intake and mineral metabolism in mothers and their newborn infants. Br Med J 1980; 281 (6232): 11-4.
  13. Brooke O.G et al. Vitamin D supplements in pregnant Asian women: effects on calcium status and fetal growth. Br Med J 1980; 80: 751-4.
  14. Datta S et al. Vitamin D deficiency in pregnant women from a non-European ethnic minority population - an interventional study. BJOG 2002; 109: 905-8.
  15. Delvin Е.E et al. Vitamin D supplementation during pregnancy: effect on neonatal calcium gomeostasis. J Pediatr 1986; 109 (2): 328-34.
  16. Davis O.K et al. Serum parathyroid hormone (PTH) in pregnant women determined by an immunoradiometric assay for intact PTH. J Clin Endocrinol Metab 1988; 67 (4): 850-2.
  17. Seely E.W et al. A prospective study of calciotropic hormones in pregnancy and post partum: reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am J Obstet Gynecol 1997; 176 (1): 214-7.
  18. Кеттайл В.М., Арки Р.А. Патофизиология эндокринной системы. Пер. с англ. М.: БИНОМ, 2007.
  19. Holick M.F. Vitamin D, sunlight and cancer connection. Anticancer Agents Med Chem 2013; 13: 70-82.

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