Results of the study of HPV-typing of anogenital area in patients with cervical intraepithelial neoplasia


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Abstract

Objective: to study the prevalence of different types of human papilloma virus (HPV) in cervix and anal canal in patients with HPV-associated cervical intraepithelial neoplasia (CIN) of varying severity.Material and methods: the clinical examination, colposcopy; high resolution anoscopy; cytology; typing of HPV.Results. The study involved 204 women, mean age 30±1.2 years. By results of inspection are formed 2 groups: 1 - 92 (45%) with CIN I-III, 2 - 112 (55%) without CIN. In group 1 in the cervical canal were detected HPV 16, 68 (р<0.05), in anal region 15, 56 (р<0.05). In group 2 in the cervical canal were detected HPV 16 (21.4%), 52(19.6%), 31, 44 (12.5%), 33 (10.7%), in anal region 44 (25%), 31 (19.4%), 53, 6(13.8%), 16, 52, 11, 18 (11.1%). In patients in group 1, 1.5 times more likely was found changes of anal epithelium compared with the group 2. Abnormal anal cytology was found in 12% of patients. High risk HPV cause more severe changes in the anal epithelium similar to the cervix.Conclusion. In patients with HPV-associated diseases of anogenital region revealed differences in the types of HPV in the cervical canal and anal region. The dominant type of HPV in women with CIN in the cervix and anus is the HPV type 16. HPV-associated cervical disease, including CIN, pose a risk of infection and HPV-associated diseases of the anal region, including anal intraepithelial neoplasia.

About the authors

L A Sulamanidze

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: lika.sulamanidze@gmail.com
аспирант ФГБУ НЦАГиП им. акад. В.И.Кулакова 1179974, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

N M Nazarova

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: grab2@yandex.ru
д-р мед. наук, вед. науч. сотр. научно- поликлинического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова 1179974, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

V N Prilepskaya

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: VPrilepskaya@mail.ru
д-р мед. наук, проф., зам. дир., рук. научно- поликлинического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова 1179974, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

O V Burmenskaya

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: o_bourmenskaya@oparina4.ru
д-р биол. наук, науч. сотр. лаб. молекулярно-генетических методов ФГБУ НЦАГиП им. акад. В.И.Кулакова 1179974, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

T A Demura

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: demura-t@yandex.ru
д-р мед. наук, ст. науч. сотр. 1-го патологоанатомического отд-ния ФГБУ НЦАГиП им. акад. В.И. Кулакова 1179974, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

S S Gordeev

N.N.Blokhin Russian Cancer Research Center

Email: ss.netoncology@gmail.com
канд. мед. наук, хирург-онколог хирургического отд- ния №3 ФГБНУ РОНЦ им. Н.Н.Блохина 115478, Russian Federation, Moscow, Kashirskoe sh., d. 23

V D Chuprynin

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: v_chuprynin@oparina4.ru
канд. мед. наук, рук. хирургического отд-ния ФГБУ НЦАГиП им. акад. В.И.Кулакова 1179974, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

D Yu Trofimov

V.I.Kulakov Research Center for Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation

Email: d.trofimov@dna-tech.ru
д-р биол. наук, зав. лаб. молекулярно- генетических методов ФГБУ НЦАГиП им. акад. В.И.Кулакова 1179974, Russian Federation, Moscow, ul. Akademika Oparina, d. 4

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