Obstetric and perinatal outcomes among pregnant women after influenza vaccination and after transferred respiratory infection


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Abstract

Objective. To examine a course of pregnancy, perinatal outcomes in pregnant women vaccinated against influenza and pregnant women who have had an acute respiratory infection (ARI). Material and methods. A comparative study of 108 pregnant women, vaccinated against influenza with vaccines Grippol® plus and Agrippal S1, and 93 unvaccinated; as well as study of 185 pregnant women (50 of whom had experienced ARI during pregnancy, 135 - not) during the 2009-2010 influenza pandemic. Were applied clinical, instrumental, immunological, statistical methods. Results. It has been proven that immunization with inactivated subunit vaccines in the second and third trimester does not impact on the clinical course of pregnancy or the intrauterine growth of fetus. Respiratory infections result in increased frequency of obstetrics pathologies (subcompensated placental insufficiency 49.6%, chronic fetal hypoxia 49.6%, gestosis 35.5% and other). Adaptation in the early neonatal period among infants born to the vaccinated women is comparable to that of infants from the placebo group. The infants born to the women having a history of ARI were 3 times or more frequent to have impaired adaptation, grade I cerebral ischemia, neonatal hyperbilirubinemia. Conclusion. Vaccination of pregnant women in the II and III trimester of gestation with immunoadjuvant and unadjuvanted subunit influenza vaccine does not affect the course of pregnancy and the early neonatal period.

About the authors

M P Kostinov

I.I.Mechnikov Research Institute of Vaccines and Sera

Email: vaccinums@gmail.com
д-р мед. наук, проф., засл. деят. науки РФ, зав. лаб. вакцинопрофилактики и иммунотерапии аллергических заболеваний ФГБНУ НИИВС им. И.И.Мечникова 105064, Russian Federation, Moscow, Malyi Kazennyi per., d. 5a

A P Cherdantsev

Ulyanovsk State University

Email: a_cherdantsev@rambler.ru
д-р мед. наук, доц. каф. педиатрии ГБОУ ВПО УлГУ 432700, Russian Federation, Ulyanovsk, pl. 100-letiia so dnia rozhdeniia V.I.Lenina, d. 4

S S Semenova

City Clinical Hospital №45 of the Department of Health of the Russian Federation

Email: Semenovasusanna@yandex.ru
врач акушер-гинеколог ГБУЗ ГП №45, филиал №4 125171, Russian Federation, Moscow, 1-ia Radiatorskaia, d. 5

D A Tarbaeva

Chita State Medical Academy

Email: dolgorma35@mail.ru
канд. мед. наук, ассистент каф. акушерства и гинекологии педиатрического фак-та повышения квалификации и профессиональной переподготовки специалистов ГБОУ ВПО ЧитГМА 672090, Russian Federation, Chita, ul. Gor'kogo, d. 39a

A A Savisko

Rostov State Medical University

Email: Annsav@mail.ru
канд. мед. наук, доц. каф. пропедевтики детских болезней с курсом здорового ребенка ГБОУ ВПО РостГМУ 344022, Russian Federation, Rostov-on-Don, per. Nakhichevanskii, d. 29

O F Serova

Moscow Regional Perinatal Center; A.I.Burnazyan Federal Medical Biophysical Center

Email: Olga-serova@yandex.ru
д-р мед. наук, проф., гл. врач ГБУЗ МО МОПЦ, зав. каф. акушерства, гинекологии и перинатологии ФГБУ ГНЦ РФ ФМБЦ им. А.И.Бурназяна 143900, Russian Federation, Balashikha, sh. Entuziastov, d. 12

S A Iozefson

Chita State Medical Academy

Email: dolgorma35@mail.ru
д-р мед. наук, проф. каф. акушерства и гинекологии педиатрического фак-та повышения квалификации и профессиональной переподготовки специалистов ГБОУ ВПО ЧитГМА 672090, Russian Federation, Chita, ul. Gor'kogo, d. 39a

N K Akhmatova

I.I.Mechnikov Research Institute of Vaccines and Sera

Email: anelly@mail.ru
д-р мед. наук, зав. лаб. механизмов регуляции иммунитета ФГБНУ НИИВС им. И.И.Мечникова 105064, Russian Federation, Moscow, Malyi Kazennyi per., d. 5a

T A Kostinova

I.I.Mechnikov Research Institute of Vaccines and Sera

Email: vaccinums@gmail.com
мл. науч. сотр. ФГБНУ НИИВС им. И.И.Мечникова 105064, Russian Federation, Moscow, Malyi Kazennyi per., d. 5a

D A Praulova

Dmitrii Rogachev Federal Research Center of Pediatric Hematology, Oncology and Immunology of the Ministry of Health of the Russian Federation

Email: Dariacherdantseva@gmail.com
врач-ординатор ФГБУ ФНКЦ ДГОИ им. Дмитрия Рогачева 117997, Russian Federation, Moscow, ul. Samory Mashela, d. 1

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