Evaluation of saturation of pregnant women with vitamin D in the application of different doses of сolekalciferol


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Abstract

This article presents the results of a randomized prospective controlled study assessing the saturation of pregnant women with vitamin D deficiency with the original difficiency or a lack of 25(OH)D, the first blood sampling and randomization was produced at 12-16 weeks. two groups of women who have been daily recieving colecalciferol in doses of 500 IU (Group 1, n = 45) and 2000 IU (group 2, n = 45) from first trimester until delivery was analyzed . Initial average level of 25(OH)D in all pregnant women had no significant difference (16,45 ng/ml and 16,5 ng/ml, respectively). None of women of first group reached the final level of 25(OH)D corresponding to the value of the norm; 95,55% of patients in group 2 (n=43) reached the level of serum 25(OH)D 30 ng/ml (mean level of 39,11 ng/ml). Research has shown the efficacy of colecalciferol intake in doses of 2,000 IU, which may be recommended for pregnant women with 25(OH)D serum <30 ng/ml.

About the authors

E L Khazova

ФГБУ Федеральный медицинский исследовательский центр им. В.А.Алмазова Минздрава России, Санкт-Петербург

науч. сотр. НИЛ репродукции и здоровья женщины Института перинатологии и педиатрии

V A Bart

ФГБУ Федеральный медицинский исследовательский центр им. В.А.Алмазова Минздрава России, Санкт-Петербург

канд. физ.-мат. наук, зав. НИЛ математического моделирования

I E Zazerskaya

ФГБУ Федеральный медицинский исследовательский центр им. В.А.Алмазова Минздрава России, Санкт-Петербург

д-р мед. наук, зав. каф. акушерства и гинекологии

E N Belyaeva

ФГБУ Федеральный медицинский исследовательский центр им. В.А.Алмазова Минздрава России, Санкт-Петербург

науч. сотр. НИЛ репродукции и здоровья женщины Института перинатологии и педиатрии

References

  1. J Clin Endocrinol Metab 2013; 98: 2337-46.
  2. De-Regil L.M, Palacios C, Ansary A et al. Vitamin D supplementation for women during pregnancy. Cochrane Collaboration, 2012.
  3. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. 2011.
  4. Holick M.F. Vitamin D deficiency. N Engl J Med 2009; 357: 266-81.
  5. Karras S.N. Maternal vitamin D status during pregnancy: the Mediterranean reality. Eur J Clin Nutr 2014.
  6. Bess Dawson-Hughes and Robert Josse. Vitamin D status in North America, Osteoporosis International, 2010.
  7. Parlak M. Severe vitamin D deficiency among pregnant women and their newborns in Turkey. J Matern Fetal Neonatal Med 2014.
  8. Dietary reference intakes for calcium and vitamin D. Institute of medicine 2010.
  9. Dietary Supplement Fact Sheet: Vitamin D. Office of Dietary Supplements National Institutes of Health Bethesda, Maryland 20892 USA. 2009.
  10. Dawodu A, Hollis B.W. Cincinnati Children’s Hospital Medical Center, Medicine and Health Sciences, United Arab Emirates University, and Tawam Hospital (G.B.), Al-Ain, United Arab Emirates; and Department of Pediatrics (B.W.H.), Medical University of South Carolina. 2014.
  11. Walker V.P et al. Vitamin D connection to pediatric infections and immune function. Pediatr Research 2009.
  12. Forouhi N.G, Luan J, Cooper A et al. Baseline serum 25-hydroxy vitamin D is predictive of future glycaemic status and insulin resistance: The MRC Ely prospective study 1. Diabetes 2008.
  13. Maghbooli Z, Hossein-Nezhad A, Karimi F et al. Correlation between vitamin D(3) deficiency and insulin resistance in pregnancy. Diabetes Metab Res Rev 2008; 24: 27-32.
  14. Clifton-Bligh R.J, McElduff P, McElduff A. Maternal vitamin D deficiency, ethnicity and gestational diabetes. Diabet Med 2008; 25: 678-84.
  15. Gale C.R et al. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 2008.
  16. Wagner C.L et al. Prevention of Rickets and Vitamin D Deficiency in Infants, Children, and Adolescents, Pediatrics, 2008.
  17. Pinelli N.R. Serum 25-Hydroxy Vitamin D and Insulin Resistance, Metabolic Syndrome, and Glucose Intolerance Among Arab Americans; Articles from Diabetes Care, American Diabetes Association. 2010.
  18. Weinert L.S. Maternal-Fetal Impact of Vitamin D Deficiency: A Critical Review. Maternal Child Health J 2014.
  19. Yap C. Vitamin d supplementation and the effects on glucose metabolism during pregnancy: a randomized controlled trial. Diabetes Care 2014.
  20. Skowrońska-Józwiak E. Assessment of adequacy of vitamin D supplementation during pregnancy. Ann Agric Environ Med 2014.
  21. Zhou J. Associations between 25-hydroxyvitamin D levels and pregnancy outcomes: a prospective observational study in southern China. Eur J Clin Nutr 2014.
  22. Новикова Т.В., Зазерская И.Е. и др. Насыщенность организма витамином D и течение перинатального периода. Обзор. Журн. акушерства и женских болезней. 2014; LXIII; 3.
  23. Heaney R et al. Human serum 25-hydrocholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 2013; 74: 204-10.
  24. Солнцев В.Н., Черкашин Д.В. Анализ корреляционной структуры факторов сердечно - сосудистого риска. Тезисы Всероссийской научно - практической конференции с международным участием «Высокотехнологические методы диагностики и лечения заболеваний сердца, крови и эндокринных органов». Бюллетень федерального центра сердца, крови и эндокринологии им. В.А.Алмазова. 2010; 2: 217-8.

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