Human papilloma virus and bacterial vaginosis: is there a connection?


Cite item

Full Text

Abstract

Analysis of the results of several studies has shown a correlation between human papillomavirus (HPV) infection and bacterial vaginosis (BV), and a more frequent persistence of HPV and its recurrence until the occurrence of HPV-associated diseases. Susceptibility to HPV tropism and local immunity's ability to eliminate the infection can be changed under the influence of a number of adverse factors. One of these factors is bacterial vaginosis (BV), which gives a balanced ecosystem of the vagina and its defense mechanisms against other infections and diseases.

About the authors

V N Prilepskaya

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва

д-р мед. наук, проф., зам. дир. по науч. работе, рук. научно-поликлинического отд-ния

N M Nazarova

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва

д-р мед. наук, вед. науч. сотр. научно-поликлинического отд-ния

References

  1. Dunne E.F, Unger E.R, Sternberg M et al. Prevalence of HPV infection among females in the United States. J Am Med Assoc 2007; 297 (8): 813-9.
  2. Gillet E, Meys J.F, Verstraelen H et al. Bacterial vaginosis is associated with uterine cervical human papillomavirus infection: a meta - analysis. BMC Infectious Diseases 2011; 11, article 10.
  3. Moscicki A.B, Hills N, Shiboski S et al. Risks for incident human papillomavirus infection and low - grade squamous intraepithelial lesion development in young females. J Am Med Assoc 2001; 285 (23): 2995-3002.
  4. Rahkola P, Mikkola T.S, Ylikorkala O, Vaisanen-Tommiska M. Association between high risk papillomavirus DNA and nitric oxide release in the human uterine cervix. Gynecol Oncol 2009; 114 (2): 323-6.
  5. Verteramo R, Pierangeli A, Mancini E et al. Human Papillomaviruses and genital co - infections in gynaecological outpatients. BMC Infect Dis 2009; 9, article 16.
  6. Kahn J.A, Lan D, Kahn R.S. Sociodemographic factors associated with high - risk human papillomavirus infection. Obstet Gynecol 2007; 110 (1): 87-95.
  7. King C.C, Jemieson D.J, Wiener J et al. Bacterial vaginosis and the natural history of human papillomavirus. Infect Dis Obstet Gynecol 2011; 319460 (10): 1155.
  8. Quayle A.J. The innate and early immune response to pathogen challenge in the female genital tract and the pivotal role of epithelial cells. J Reprod Immunol 2002; 57: 61-79.
  9. Cole A.M. Innate host defense of human vaginal and cervical mucosae. Curr Top Microbiol Immunol 2006; 306: 199-230.
  10. Iijima N, Thompson J.M, Iwasaki A. Dendritic cells and macrophages in the genitourinary tract. Mucosal Immunol 2008; 1: 451-9.
  11. Ochiel D.O, Fahey J.V, Ghosh M et al. Innate Immunity in the Female Reproductive Tract: Role of Sex Hormones in Regulating Uterine Epithelial Cell Protection Against Pathogens. Curr Womens Health Rev 2008; 4: 102-17.
  12. Eschenbach D.A, Thwin S.S, Patton D.L et al. Influence of the normal menstrual cycle on vaginal tissue, discharge, and microflora. Clin Infect Dis 2000; 30: 901-7.
  13. Valore E.V, Park C.H, Igreti S.L, Ganz T. Antimicrobial components of vaginal fluid. Am J Obstet Gynecol 2002; 187: 561-8.
  14. Rohan L.C, Sassi A.B. Vaginal drug delivery systems for HIV prevention. AAPS J 2009; 11: 78-87.
  15. Wira C.R, Grant-Tschudy K.S, Crane-Godreau M.A. Epithelial cells in the female reproductive tract: a central role as sentinels of immune protection. Am J Reprod Immunol 2005; 53: 65-76.
  16. Klein L.L, Jonscher K.R, Heerwagen M.J et al. Shotgun proteomic analysis of vaginal fluid from women in late pregnancy. Reprod Sci 2008; 15: 263-73.
  17. St John E, Mares D, Spear G.T. Bacterial vaginosis and host immunity. Curr HIV/AIDS Rep 2007; 4: 22-8.
  18. Balu R.B, Savitz D.A, Ananth C.V et al. Bacterial vaginosis, vaginal fluid neutrophil defensins, and preterm birth. Obstet Gynecol 2003; 101: 862-8.
  19. Novak R.M, Donoval B.A, Graham P.J et al. Cervicovaginal levels of lactoferrin, secretory leukocyte protease inhibitor, and RANTES and the effects of coexisting vaginoses in human immunodeficiency virus (HIV)-seronegative women with a high risk of heterosexual acquisition of HIV infection. Clin Vaccine Immunol 2007; 14: 1102-7.
  20. Valore E.V, Wiley D.J, Ganz T. Reversible deficiency of antimicrobial polypeptides in bacterial vaginosis. Infect Immun 2006; 74: 5693-702.
  21. Wiesenfeld H.C, Heine R.P, Krohn M.A et al. Association between elevated neutrophil defensin levels and endometritis. J Infect Dis 2002; 186: 792-7.
  22. Xu J, Holzman C.B, Arvidson C.G et al. Midpregnancy vaginal fluid defensins, bacterial vaginosis, and risk of preterm delivery. Obstet Gynecol 2008; 112: 524-31.
  23. Сухих Г.Т., Трофимов Д.Ю., Бурменская О.В. и др. Профиль экспрессии мРНК генов цитокинов в вагинальных мазках женщин репродуктивного возраста при неспецифическом вагините и бактериальном вагинозе. Акуш. и гинекол. 2011; 7/2: 33-8.
  24. Прилепская В.Н. Вагинальные инфекции и локальные препараты комплексного действия. В чем причина успеха? Гинекология. 2011; 13 (6).
  25. Лаврова Л.В., Левочкина Л.Н., Копейкина Е.А., Шеманаева Т.В. Бактериальный вагиноз: сравнительная оценка эффективности локальной антибактериальной терапии. Гинекология. 2011; 13 (3): 41-3.
  26. Уварова Е.В., Анкирская А.С., Григоренко Ю.П., Кумыкова З.Х. Эффективность терапии бактериального вагиноза у женщин вне беременности (результаты многоцентрового исследования). Акуш. и гинекол. 2010; 1: 1-10.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2014 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).