Embryo aneuploidy and ivf outcomes in patients with different spermatozoa aneuploidy rates


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Abstract

Our goal was to study the 13, 18, 21, X, Y chromosomes aneuploidy rate in the embryos of the couples with different spermatozoa aneuploidy rate.In prospective cohort study 56 infertile couples were divided into 3 groups by the spermatozoa aneuploidy rate and preimplantation genetic diagnosis (PGD) by fluorescence in situ hybridization performance.There was a statistically significant correlation between the spermatozoa aneuploidy rate and the number of aneuploid embryos (r=0,19; p=0,0248). The most common types of chromosomal aberrations were 21 and X chromosome monosomy, and sex chromosomes polysomy. In the PGD group with spermatozoa aneuploidy level >0,7% the pregnancy rate was 50% as compared with no-PGD group with pregnancy rate of 8,6% (Kaplan–Meier; p=0,0135).Patients with high rate of spermatozoa aneuploidy are at risk of chromosomal aberrations in the embryos.

About the authors

S A Sokur

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва

Email: sokursv@yandex.ru
аспирант лаб. репродуктивной генетики

N V Dolgushina

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва

Email: n_dolgushina@oparina4.ru
д-р мед. наук, рук. Службы научно-организационного обеспечения

Zh I Glinkina

ООО Центр материнства и репродуктивной медицины «Петровские ворота», Москва

Email: janna435@yandex.ru
д-р биол. наук, зав. лаб. репродуктивной генетики

A G Gorshkova

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва

Email: a_gorshkova@oparina4.ru
аспирант отд-ния вспомогательных технологий в лечении бесплодия

E A Kalinina

ФГБУ Научный центр акушерства, гинекологии и перинатологии им. акад. В.И.Кулакова Минздрава России, Москва

Email: e_kalinina@oparina4.ru
д-р мед. наук, зав. отд-нием вспомогательных технологий в лечении бесплодия

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