Potential and perspectives of local application of hyaluronic acid in vulvovaginal atrophy in women of reproductive age: A review
- Authors: Prilepskaya V.N.1, Nazarova N.M.1, Devyatkina A.R.1, Abakarova P.R.1, Mezhevitinova E.A.1
-
Affiliations:
- Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
- Issue: Vol 26, No 3 (2024)
- Pages: 254-259
- Section: REVIEW
- URL: https://journals.rcsi.science/2079-5831/article/view/265208
- DOI: https://doi.org/10.26442/20795696.2024.3.202932
- ID: 265208
Cite item
Full Text
Abstract
Disruption of the structure and function of the vulvovaginal epithelium in women of reproductive age is accompanied by impaired sexual function and a decrease in the quality of life. This review analyses research on the use of hyaluronic acid (HA) for women of reproductive age with conditions and diseases manifesting as vulvovaginal atrophy. HA is involved in various physiological processes, including tissue regeneration, cell migration and proliferation during inflammation, and helps maintain water balance and tissue integrity. Local therapy with HA is effective in treating the symptoms of vulvovaginal atrophy in women of reproductive age associated with hypoestrogenism, both as a monotherapy and in combination with other treatments. It improves sexual function and quality of life, helping women to improve their sexual lives and living standards.
Full Text
##article.viewOnOriginalSite##About the authors
Vera N. Prilepskaya
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: v_prilepskaya@oparina4.ru
ORCID iD: 0000-0003-3993-7629
D. Sci. (Med.), Prof.
Russian Federation, MoscowNiso M. Nazarova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Author for correspondence.
Email: n_nazarova@oparina4.ru
ORCID iD: 0000-0001-9499-7654
D. Sci. (Med.)
Russian Federation, MoscowAnastasia R. Devyatkina
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: grinasta26@mail.ru
ORCID iD: 0009-0006-1742-7555
Resident
Russian Federation, MoscowPatimat R. Abakarova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: p_abakarova@oparina4.ru
ORCID iD: 0000-0002-8243-5272
Cand. Sci. (Med.)
Russian Federation, MoscowElena A. Mezhevitinova
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology
Email: mejevitinova@mail.ru
ORCID iD: 0000-0003-2977-9065
D. Sci. (Med.)
Russian Federation, MoscowReferences
- Portman DJ, Gass ML; Vulvovaginal Atrophy Terminology Consensus Conference Panel. Genitourinary syndrome of menopause: New terminology for vulvovaginal atrophy from the International Society for the Study of Women's Sexual Health and the North American Menopause Society. Menopause. 2014;21(10):1063-8. doi: 10.1097/GME.0000000000000329
- Lev-Sagie A. Vulvar and vaginal atrophy: Physiology, clinical presentation, and treatment considerations. Clin Obs Gynecol. 2015;58(3):476-91. doi: 10.1097/GRF.0000000000000126
- Mac Bride MB, Rhodes DJ, Shuster LT. Vulvovaginal atrophy. Mayo Clin Proc. 2010;85(1):87-94. doi: 10.4065/mcp.2009.0413
- Alvisi S, Gava G, Orsili I, et al. Vaginal health in menopausal women. Medicina (Kaunas). 2019;55(10):615. doi: 10.3390/medicina55100615
- Robinson D, Cardozo LD. The role of estrogens in female lower urinary tract dysfunction. Urology. 2003;62(4 Suppl. 1):45-51. doi: 10.1016/s0090-4295(03)00676-9
- Escobar C, Rosenblum N. Vaginal estrogen – what a urologist should know. Urology. 2021;151:37-43. doi: 10.1016/j.urology.2020.05.034
- Bayer IS. Hyaluronic acid and controlled release: A review. Molecules. 2020;25(11):2649. doi: 10.3390/molecules25112649
- Toole BP. Hyaluronan: From extracellular glue to pericellular cue. Nat Rev Cancer. 2004;4(7):528-39. doi: 10.1038/nrc1391
- Fallacara A, Baldini E, Manfredini S, Vertuani S. Hyaluronic acid in the third millennium. Polymers (Basel). 2018;10(7):701. doi: 10.3390/polym10070701
- Leeman LM, Rogers RG. Sex after childbirth: Postpartum sexual function. Obstet Gynecol. 2012;119(3):647-55. doi: 10.1097/AOG.0b013e3182479611
- Banaei M, Azizi M, Moridi A, et al. Sexual dysfunction and related factors in pregnancy and postpartum: A systematic review and meta-analysis protocol. Syst Rev. 2019;8(1):161. doi: 10.1186/s13643-019-1079-4
- Rowland M, Foxcroft L, Hopman WM, Patel R. Breastfeeding and sexuality immediately postpartum. Can Fam Physician. 2005;51(10):1366-7. PMID: 16926969
- Agarwal SK, Kim J, Korst LM, Hughes CL. Application of the estrogen threshold hypothesis to the physiologic hypoestrogenemia of lactation. Breastfeed Med. 2015;10(2):77-83. doi: 10.1089/bfm.2014.0030
- Gustavino C, Sala P, Cusini N, et al. Efficacy and safety of prolonged-release hyaluronic acid derivative vaginal application in the postpartum period: A prospective randomised clinical trial. Ann Med. 2021;53(1):1589-97. doi: 10.1080/07853890.2021.1974083
- Менопауза и климактерическое состояние у женщины. Клинические рекомендации РОАГ. 2021. Режим доступа: https://cr.minzdrav.gov.ru/recomend/117_2. Ссылка активна на 16.05.2024 [Menopauza i klimaktericheskoe sostoianie u zhenshchiny. Klinicheskie rekomendatsii ROAG. 2021. Available at: https://cr.minzdrav.gov.ru/recomend/117_2. Accessed: 16.05.2024 (in Russian)].
- Ekin M, Yaşar L, Savan K, et al. The comparison of hyaluronic acid vaginal tablets with estradiol vaginal tablets in the treatment of atrophic vaginitis: A randomized controlled trial. Arch Gynecol Obstet. 2011;283(3):539-43. doi: 10.1007/s00404-010-1382-8
- Jokar A, Davari T, Asadi N, et al. Comparison of the hyaluronic acid vaginal cream and conjugated estrogen used in treatment of vaginal atrophy of menopause women: A randomized controlled clinical trial. Int J Community Based Nurs Midwifery. 2016;4(1):69-78. PMID: 26793732
- Cox P, Panay N. Vulvovaginal atrophy in women after cancer. Climacteric. 2019;22(6):565-71. doi: 10.1080/13697137.2019.1643180
- Sabatini R, Cagiano R. Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives. Contraception. 2006;74(3):220-3. doi: 10.1016/j.contraception.2006.03.022
- Handy AB, McMahon LN, Goldstein I, Meston CM. Reduction in genital sexual arousal varies by type of oral contraceptive pill. J Sex Med. 2023;20(8):1094-102. doi: 10.1093/jsxmed/qdad072
- Cotangco K, Class QA, Johnson TP, Kothari R. Cervical cancer survivors' attitudes and understanding of menopause and hormone therapy. Menopause. 2020;27(6):701-5. doi: 10.1097/GME.0000000000001520
- Dafni U, Tsourti Z, Alatsathianos I. Breast cancer statistics in the European Union: Incidence and survival across European Countries. Breast Care (Basel). 2019;14(6):344-53. doi: 10.1159/000503219
- Lubián López DM. Management of genitourinary syndrome of menopause in breast cancer survivors: An update. World J Clin Oncol. 2022;13(2):71-100. doi: 10.5306/wjco.v13.i2.71
- Santen RJ, Stuenkel CA, Davis SR, et al. Managing menopausal symptoms and associated clinical issues in breast cancer survivors. J Clin Endocrinol Metab. 2017;102(10):3647-61. doi: 10.1210/jc.2017-01138
- Kingsberg SA, Larkin L, Krychman M, et al. WISDOM survey: Attitudes and behaviors of physicians toward vulvar and vaginal atrophy (VVA) treatment in women including those with breast cancer history. Menopause. 2019;26(2):124-31. doi: 10.1097/GME.0000000000001194
- The NAMS 2020 GSM Position Statement Editorial Panel. The 2020 genitourinary syndrome of menopause position statement of The North American Menopause Society. Menopause. 2020;27(9):976-92. doi: 10.1097/GME.0000000000001609
- Shah MB, Hoffstetter S. Contraception and sexuality. Minerva Ginecol. 2010;62(4):331-47. PMID: 20827250
- Casey PM, MacLaughlin KL, Faubion SS. Impact of contraception on female sexual function. J Womens Health (Larchmt). 2017;26(3):207-13. doi: 10.1089/jwh.2015.5703
- Журавлева Ю.А., Прохорова О.В., Гептинг Н.А., и др. Женская сексуальность и комбинированные оральные контрацептивы: проблемы и возможности коррекции. Российский вестник акушера-гинеколога. 2020;20(6):101-6 [Zhuravleva JA, Prokhorova OV, Gepting NA, et al. Female sexuality and combined oral contraceptive pills: Administration and correction issues. Russian Bulletin of Obstetrician-Gynecologist. 2020;20(6):101-6 (in Russian)]. doi: 10.17116/rosakush202020061101
- Krapf JM, Mitchell L, Holton MA, Goldstein AT. Vulvar lichen sclerosus: Current perspectives. Int J Womens Health. 2020;12:11-20. doi: 10.2147/IJWH.S191200
- Singh N, Ghatage P. Etiology, clinical features, and diagnosis of vulvar lichen sclerosus: A scoping review. Obstet Gynecol Int. 2020;2020:7480754. doi: 10.1155/2020/7480754
- Шперлинг Н.В., Шперлинг М.И. Лечение и профилактика рецидивирования склероатрофического лихена половых органов у женщин. Акушерство и гинекология. 2022;12:70-8 [Shperling NV, Shperling MI. Treatment and prevention of recurrent genital lichen sclerosus in women. Obstetrics and Gynecology. 2022;12:70-8 (in Russian)]. doi: 10.18565/aig.2022.280
- Van der Meijden WI, Boffa MJ, Ter Harmsel B, et al. 2021 European guideline for the management of vulval conditions. J Eur Acad Dermatol Venereol. 2022;36(7):952-72. doi: 10.1111/jdv.18102
- Лишай красный плоский. Клинические рекомендации. 2020. Режим доступа: https://cnikvi.ru/docs/klinicheskie-rekomendacii/КР%20КПЛ%202020.docx. Ссылка активна на 16.05.2024 [Lishai krasnyi ploskii. Klinicheskie rekomendatsii. 2020. Available at: https://cnikvi.ru/docs/klinicheskie-rekomendacii/КР%20КПЛ%202020.docx. Accessed: 16.05.2024 (in Russian)].
- Charman CR, Morris AD, Williams HC. Topical corticosteroid phobia in patients with atopic eczema. Br J Dermatol. 2000;142(5):931-6. DOI:10.1046 j.1365-2133.2000.03473.x
- Aubert-Wastiaux H, Moret L, Le Rhun A, et al. Topical corticosteroid phobia in atopic dermatitis: A study of its nature, origins and frequency. Br J Dermatol. 2011;165(4):808-14. doi: 10.1111/j.1365-2133.2011.10449.x
- Dreisler E, Kjer JJ. Asherman's syndrome: Current perspectives on diagnosis and management. Int J Womens Health. 2019;11:191-8. doi: 10.2147/IJWH.S165474
- Lee WL, Liu CH, Cheng M, et al. Focus on the primary prevention of intrauterine adhesions: Current concept and vision. Int J Mol Sci. 2021;22(10):5175. doi: 10.3390/ijms22105175
- Tafti SZG, Javaheri A, Firoozabadi RD, et al. Role of hyaluronic acid intrauterine injection in the prevention of Asherman's syndrome in women undergoing uterine septum resection: An RCT. Int J Reprod Biomed. 2021;19(4):339-46. doi: 10.18502/ijrm.v19i4.9060
- Huang CY, Chang WH, Cheng M, et al. Crosslinked hyaluronic acid gels for the prevention of intrauterine adhesions after a hysteroscopic myomectomy in women with submucosal myomas: A prospective, randomized, controlled trial. Life (Basel). 2020;10(5):67. DOI:10.3390life10050067
- Wang YQ, Song XH, Wu SL, et al. Comparison of autocross-linked hyaluronic acid gel and intrauterine device for preventing intrauterine adhesions in infertile patients: A randomized clinical trial. Gynecol Minim Invasive Ther. 2020;9(2):74-80. doi: 10.4103/GMIT.GMIT_103_19
Supplementary files
