The birth of a healthy child in a married couple with a history of multiple unsuccessful attempts at ART by selecting sperm on oocyte-cumulus complexes. Case report

Cover Page

Cite item

Full Text

Abstract

In male infertility, couples must use assisted reproductive technologies with the intracytoplasmic sperm injection (ICSI) technique. A significant disadvantage of ICSI is bypassing natural selection barriers since selective processes in the female reproductive tract are replaced by the choice of an embryologist based on sperm motility and morphological criteria. Various selection methods are being actively studied, bringing fertilization by ICSI closer to physiological, ensuring the selection of sperm with high DNA quality and good potential for fertilization. The article presents a clinical case of the birth of a healthy child in a married couple with severe male infertility and many ineffective attempts at assisted reproductive technologies using the method of sperm selection on oocyte-cumulus complexes. The child is physically healthy and develops according to age.

About the authors

Alina V. Chistyakova

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: alinadubinina_07@mail.ru

Graduate Student

Russian Federation, Moscow

Alina A. Babayan

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: a_babayan@oparina4.ru
ORCID iD: 0000-0003-0963-6382

Cand. Sci. (Med.)

Russian Federation, Moscow

Alina А. Dovgan

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: lina.dovgan@gmail.com
ORCID iD: 0000-0002-4927-3590

Obstetrician-Gynecologist

Russian Federation, Moscow

Natalya P. Makarova

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: np_makarova@oparina4.ru
ORCID iD: 0000-0003-1396-7272

D. Sci. (Biol.)

Russian Federation, Moscow

Natalya N. Lobanova

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: n_lobanova@oparina4.ru

Res. Assist.

Russian Federation, Moscow

Veronika Yu. Smolnikova

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Author for correspondence.
Email: v_smolnikova@oparina4.ru
ORCID iD: 0000-0003-4866-8002

D. Sci. (Med.), Gynecology and Perinatology

Russian Federation, Moscow

References

  1. Williams M, Barratt CL, Hill CJ, et al. Recovery of artificially inseminated spermatozoa from the Fallopian tubes of a woman undergoing total abdominal hysterectomy. Hum Reprod. 1992;7(4):506-9. doi: 10.1093/oxfordjournals.humrep.a137680
  2. Palermo GD, Neri QV, Takeuchi T, Rosenwaks Z. ICSI: Where We Have Been and Where We Are Going. Semin Reprod Med. 2009;27(2):191-201. doi: 10.1055/s-0029-1202309
  3. Всемирная организация здравоохранения. Руководство ВОЗ по исследованию и обработке эякулята человека: Пятое издание. М.: КАПИТАЛ ПРИНТ, 2012. Режим доступа: https://apps.who.int/iris/handle/10665/112544. Ссылка активна на 29.01.2023 [Vsemirnaia organizatsiia zdravookhraneniia. Rukovodstvo VOZ po issledovaniiu i obrabotke eiakuliata cheloveka: Piatoe izdanie. Moscow: KAPITAL PRINT, 2012. Available at: https://apps.who.int/iris/handle/10665/112544. Accessed: 29.01.2023 (in Russian)].
  4. Malvezzi H, Sharma R, Agarwal A, et al. Sperm quality after density gradient centrifugation with three commercially available media: a controlled trial. Reprod Biol Endocrinol. 2014;12:121. doi: 10.1186/1477-7827-12-121
  5. Parmegiani L, Cognigni GE, Bernardi S, et al. Physiologic ICSI: Hyaluronic acid (HA) favors selection of spermatozoa without DNA fragmentation and with normal nucleus, resulting in improvement of embryo quality. Fertil Steril. 2010;93(2):598-604. doi: 10.1016/j.fertnstert.2009.03.033
  6. Luna D, Hilario R, Dueñas-Chacón J, et al. The IMSI Procedure Improves Laboratory and Clinical Outcomes without Compromising the Aneuploidy Rate When Compared to the Classical ICSI Procedure. Clin Med Insights Reprod Health. 2015;9:29-37. doi: 10.4137/CMRH.S33032
  7. Li K, Li R, Ni Y, et al. Novel distance-progesterone-combined selection approach improves human sperm quality. J Transl Med. 2018;16(1):203. doi: 10.1186/s12967-018-1575-7
  8. Pérez-Cerezales S, Laguna-Barraza R, de Castro AC, et al. Sperm selection by thermotaxis improves ICSI outcome in mice. Sci Rep. 2018;8(1):2902. doi: 10.1038/s41598-018-21335-8
  9. De Martin H, Cocuzza MS, Tiseo BC, et al. Positive rheotaxis extended drop: a one-step procedure to select and recover sperm with mature chromatin for intracytoplasmic sperm injection. J Assist Reprod Genet. 2017;34(12):1699-708. doi: 10.1007/s10815-017-1024-1
  10. Wang C, Feng G, Shu J, et al. Cumulus oophorus complexes favor physiologic selection of spermatozoa for intracytoplasmic sperm injection. Fertil Steril. 2018;109(5):823-31.
  11. Zhuo L, Kimata K. Cumulus Oophorus Extracellular Matrix: Its Construction and Regulation. Cell Struct Funct. 2001;26(4):189-96. doi: 10.1016/j.fertnstert.2017.12.026
  12. Huszar G, Ozkavukcu S, Jakab A, et al. Hyaluronic acid binding ability of human sperm reflects cellular maturity and fertilizing potential: selection of sperm for intracytoplasmic sperm injection. Curr Opin Obstet Gynecol. 2006;18(3):260-7. doi: 10.1097/01.gco.0000193018.98061.2f
  13. Sun F, Bahat A, Gakamsky A, et al. Human sperm chemotaxis: both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants. Hum Reprod. 2005;20(3):761-7. doi: 10.1093/humrep/deh657
  14. Hong SJ, Chiu PC, Lee KF, et al. Cumulus cells and their extracellular matrix affect the quality of the spermatozoa penetrating the cumulus mass. Fertil Steril. 2009;92(3):971-8. doi: 10.1016/j.fertnstert.2008.07.1760
  15. Franken DR, Bastiaan HS. Can a cumulus cell complex be used to select spermatozoa for assisted reproduction? Andrologia. 2009;41(6):369-76. doi: 10.1111/j.1439-0272.2009.00938.x
  16. Naknam W, Salang L, Sothornwit J, et al. Effect of sperm selection method by cumulus oophorus complexes and conventional sperm preparation method on sperm quality and DNA fragmentation for assisted reproduction techonology. Eur J Obstet Gynecol Reprod Biol. 2019;243:46-50. doi: 10.1016/j.ejogrb.2019.10.004
  17. Gardner DK, Schoolcraft WB. Culture and transfer of human blastocysts. Curr Opin Obstet Gynecol. 1999;11(3):307-11. doi: 10.1097/00001703-199906000-00013

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2023 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Согласие на обработку персональных данных

 

Используя сайт https://journals.rcsi.science, я (далее – «Пользователь» или «Субъект персональных данных») даю согласие на обработку персональных данных на этом сайте (текст Согласия) и на обработку персональных данных с помощью сервиса «Яндекс.Метрика» (текст Согласия).