The reproductive function of patients with prior atypical endometrial hyperplasia and endometrial cancer treatment: cohort study

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Abstract

Aim. To define the management of realization of reproductive function implementation in patients experienced atypical endometrial hyperplasia and endometrial cancer IA stage.

Materials and methods. 150 patients aged 21–42 years were included. Among them 78 patients with atypical endometrial hyperplasia (group 1) and 72 – with endometrial cancer IA stage (group 2). General clinical, anamnestic and laboratory examination and follow-up with monitoring of gonadotropins and steroid hormones, as well as pelvic ultrasound supplemented with outcomes of reproductive function and in vitro fertilization (IVF) programs.

Results. It was shown a possibility of spontaneous pregnancy in young patients with regular cycles without other infertility factors with pathomorfosis 2–3 stages and the endometrial receptivity. The practicability of IVF-programs with frozen oocytes and embryo transfer in young women with a lower ovarian reserve and high-risk cancer relapse was demonstrated when their reproductive plan was uncertain.

Conclusion. The reproductive function in patients who experienced atypical endometrial hyperplasia and endometrial cancer IA stage might be realized through a personified approach using assisted reproductive technologies and modified IVF-programs with frozen oocytes and embryo transfer.

About the authors

Lana G. Dzhanashvili

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Author for correspondence.
Email: lana.janashvili@gmail.com
ORCID iD: 0000-0002-2891-3974

Cand. Sci. (Med.)

Russian Federation, Moscow

Nelly A. Khachatryan

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: lana.janashvili@gmail.com
ORCID iD: 0000-0001-6833-1787

Cand. Sci. (Med.)

Russian Federation, Moscow

Tat'iana A. Nazarenko

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: lana.janashvili@gmail.com
ORCID iD: 0000-0002-5823-1667

D. Sci. (Med.), Prof.

Russian Federation, Moscow

Al'mina M. Biriukova

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: lana.janashvili@gmail.com

Cand. Sci. (Med.)

Russian Federation, Moscow

Irina E. Dmitrieva

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Email: lana.janashvili@gmail.com
ORCID iD: 0000-0001-5119-3816

Graduate Student

Russian Federation, Moscow

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2. Fig. 1. The personalized approach of infertility treatment in patients with prior atypical endometrial hyperplasia and endometrial cancer treatment.

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3. Fig. 2. Modified frozen embryo transfer protocol.

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