Regulation of Telomerase Activity
- Авторы: Nalobin D.S.1, Galiakberova A.A.1, Alipkina S.I.1, Glukhov A.I.1,2
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Учреждения:
- Moscow State University
- Sechenov First Moscow State Medical University
- Выпуск: Том 8, № 2 (2018)
- Страницы: 142-154
- Раздел: Article
- URL: https://journals.rcsi.science/2079-0864/article/view/206775
- DOI: https://doi.org/10.1134/S2079086418020068
- ID: 206775
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Аннотация
The published data on the regulation of telomerase activity are systemized. The structure and functions of telomeres and telomerase are described. The main pathways of epigenetic regulation of telomerase activity—modification of the TERT (telomerase reserve transcriptase) gene histone and its methylation— are described. Particular attention is paid to the regulation of telomerase activity at the transcriptional level (transcriptional activators and inhibitors of TERT, as well as two-way transcription regulators) and posttranscriptional regulation (alternative splicing of TERT mRNA, phosphorylation, and ubiquitination of TERT).
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Об авторах
D. Nalobin
Moscow State University
Автор, ответственный за переписку.
Email: Denis.Nalobin@gmail.com
Россия, Moscow
A. Galiakberova
Moscow State University
Email: Denis.Nalobin@gmail.com
Россия, Moscow
S. Alipkina
Moscow State University
Email: Denis.Nalobin@gmail.com
Россия, Moscow
A. Glukhov
Moscow State University; Sechenov First Moscow State Medical University
Email: Denis.Nalobin@gmail.com
Россия, Moscow; Moscow
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