Heterogeneity and Plasticity of Immune Inflammatory Responses in the Tumor Microenvironment: Their Role in the Antitumor Effect and Tumor Aggressiveness
- Autores: Perelmuter V.1, Tashireva L.1, Manskikh V.2, Denisov E.1,3, Savelieva O.1,3, Kaygorodova E.1, Zavyalova M.1,3,4
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Afiliações:
- Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
- Department of Bioengineering and Bioinformatics, Moscow State University
- Tomsk State University
- Siberian State Medical University
- Edição: Volume 8, Nº 5 (2018)
- Páginas: 431-448
- Seção: Article
- URL: https://journals.rcsi.science/2079-0864/article/view/206645
- DOI: https://doi.org/10.1134/S2079086418050055
- ID: 206645
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Resumo
This review considers the role that immune inflammatory responses (IIRs) play in tumor development and progression. Intratumoral IIR heterogeneity is presumably due to simultaneous differentiation and activation of certain T helper (Th) subpopulations and macrophages in various loci of the tumor, their phenotypic plasticity, and their antagonism of Th1 and Th2 responses. Evidence is provided to demonstrate that the IIR type in the tumor microenvironment determines the probability of the epithelial–mesenchymal transition (EMT), the emergence of invasive properties in tumor cells, the formation of tumor and premetastatic niches, and chemosensitivity. It is hypothesized that the effect of IIRs on tumor cells depends on the IIR type, which determines the cell and cytokine spectrum in the tumor microenvironment, rather than on the efficiency of specific immune responses to tumor antigens. Lastly, it is assumed that more efficient targets for IIR guidance are not provided by single molecules, but rather by the signaling pathways that can permanently prevent the Th2-type IIRs or suppress inflammatory reactions in the tumor.
Sobre autores
V. Perelmuter
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: d_evgeniy@oncology.tomsk.ru
Rússia, Tomsk, 634050
L. Tashireva
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: d_evgeniy@oncology.tomsk.ru
Rússia, Tomsk, 634050
V. Manskikh
Department of Bioengineering and Bioinformatics, Moscow State University
Email: d_evgeniy@oncology.tomsk.ru
Rússia, Moscow, 119991
E. Denisov
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Tomsk State University
Autor responsável pela correspondência
Email: d_evgeniy@oncology.tomsk.ru
Rússia, Tomsk, 634050; Tomsk, 634050
O. Savelieva
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Tomsk State University
Email: d_evgeniy@oncology.tomsk.ru
Rússia, Tomsk, 634050; Tomsk, 634050
E. Kaygorodova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences
Email: d_evgeniy@oncology.tomsk.ru
Rússia, Tomsk, 634050
M. Zavyalova
Cancer Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences; Tomsk State University; Siberian State Medical University
Email: d_evgeniy@oncology.tomsk.ru
Rússia, Tomsk, 634050; Tomsk, 634050; Tomsk, 634050