Email this article Strategies for Modulation of Pharmacokinetics of Recombinant Therapeutic Proteins
- Authors: Zvonova E.A.1,2, Tyurin A.A.2,3, Soloviev A.A.2, Goldenkova-Pavlova I.V.3
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Affiliations:
- Generium International Biotechnological Center
- Timiryazev Russian State Agrarian University Moscow
- Timiryazev Institute of Plant Physiology
- Issue: Vol 8, No 2 (2018)
- Pages: 124-141
- Section: Article
- URL: https://journals.rcsi.science/2079-0864/article/view/206769
- DOI: https://doi.org/10.1134/S2079086418020093
- ID: 206769
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Abstract
The review describes current approaches to the optimization of pharmacokinetic properties of pharmaceutical proteins in order to achieve the maximum therapeutic effect. Examples of such technologies, including PEGylation, PEG mimetics, glycosylation, protein–protein fusion, and their advantages and limitations are discussed.
About the authors
E. A. Zvonova
Generium International Biotechnological Center; Timiryazev Russian State Agrarian University Moscow
Email: irengold58@gmail.com
Russian Federation, Vol’gincky, Vladimir oblast, 601125; Moscow, 127550
A. A. Tyurin
Timiryazev Russian State Agrarian University Moscow; Timiryazev Institute of Plant Physiology
Email: irengold58@gmail.com
Russian Federation, Moscow, 127550; Moscow, 127276
A. A. Soloviev
Timiryazev Russian State Agrarian University Moscow
Email: irengold58@gmail.com
Russian Federation, Moscow, 127550
I. V. Goldenkova-Pavlova
Timiryazev Institute of Plant Physiology
Author for correspondence.
Email: irengold58@gmail.com
Russian Federation, Moscow, 127276
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