Prediction of individual chemoprophylaxis for radiation carcinogenesis in experiment

Abstract

The predictive possibilities of cytological, genetic, and biochemical indicators of tumor development with the action of ionizing radiation are considered. The results are presented for the use of the genotoxicity indicator, which makes it possible to evaluate changes in the content and structure of DNA in the blood of rats, in the prediction of the efficacy of α-difluoromethylornitin and extracts of Eleutherococcus or Leuzea as possible chemopreventive drugs in radiation carcinogenesis. A significant decrease in the genotoxicity indicator in comparison with the frequency and multiplicity of tumors developed after irradiation was observed only in the case of neoplasms in the endocrine and reproductive organs of rats receiving the preventive Eleutherococcus extract.