The role of cytokines in memory consolidation
- Authors: Malashenkova I.K.1,2, Krynskiy S.A.1,2, Khailov N.A.1, Kazanova G.V.1, Velichkovsky B.B.3, Didkovsky N.A.2
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Affiliations:
- National Research Center
- Research Institute of Physicochemical Medicine
- Department of Psychology
- Issue: Vol 6, No 2 (2016)
- Pages: 126-140
- Section: Article
- URL: https://journals.rcsi.science/2079-0864/article/view/206212
- DOI: https://doi.org/10.1134/S2079086416020055
- ID: 206212
Cite item
Abstract
This review discusses the molecular mechanisms underlying memory consolidation, in particular, the neuroimmune interactions that take place during memory consolidation. Animal models of hippocampus-dependent learning show that cytokines secreted by immune cells are necessary for the neural functions that underlie cognition, such as the long-term potentiation of synaptic plasticity and neurogenesis in the subgranular zone of the hippocampus. The basic principles of neuroimmune interactions in acute and chronic stress are discussed, as well as the causes of neuroimmune dysregulation that may compromise cognitive functions and promote the development of neurodegenerative pathology.
About the authors
I. K. Malashenkova
National Research Center; Research Institute of Physicochemical Medicine
Email: didkovskinic@gmail.com
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123182; ul. Malaya Pirogovskaya 1A, Moscow, 119435
S. A. Krynskiy
National Research Center; Research Institute of Physicochemical Medicine
Email: didkovskinic@gmail.com
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123182; ul. Malaya Pirogovskaya 1A, Moscow, 119435
N. A. Khailov
National Research Center
Email: didkovskinic@gmail.com
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123182
G. V. Kazanova
National Research Center
Email: didkovskinic@gmail.com
Russian Federation, pl. Akademika Kurchatova 1, Moscow, 123182
B. B. Velichkovsky
Department of Psychology
Email: didkovskinic@gmail.com
Russian Federation, Moscow, 119991
N. A. Didkovsky
Research Institute of Physicochemical Medicine
Author for correspondence.
Email: didkovskinic@gmail.com
Russian Federation, ul. Malaya Pirogovskaya 1A, Moscow, 119435