Role of Myeloperoxidase, Paraoxonase, and Nitric Oxide System in the Blood and Pericardial Fluid of Patients with Ischemic Heart Disease after Direct Myocardial Revascularization
- 作者: Vnukov V.1, Sidorov R.2, Gvaldin D.1, Milyutina N.1, Ananyan A.1, Pospelov D.2, Plotnikov A.1, Shlyk I.2, Doltmurzieva N.2
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隶属关系:
- Southern Federal University
- Rostov State Medical University
- 期: 卷 9, 编号 4 (2019)
- 页面: 426-433
- 栏目: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/206753
- DOI: https://doi.org/10.1134/S2079057019040167
- ID: 206753
如何引用文章
详细
To study the role of paraoxonase, myeloperoxidase, arginase, asymmetric dimethylarginine, and nitric oxide in the mechanisms of the pathogenesis of postpericardiotomy syndrome (PPCS), 76 patients with ischemic heart disease (IHD) who underwent coronary artery bypass grafting were examined. Patients were divided into two groups: Group 1, IHD patients who were not diagnosed with PPCS as a result of clinical studies, and Group 2, IHD patients who were diagnosed with PPCS. The results indicate that the postoperative period after coronary artery bypass grafting is associated with the inhibition of paraoxonase, the activation of myeloperoxidase, enhanced arginase activity, increased nitrite/nitrate and asymmetric dimethylarginine levels; it may also be accompanied by the development of endothelial dysfunction and increased systemic inflammatory response. In the present work, inverse correlations were found between the paraoxonase aryl esterase activity and myeloperoxidase activity in plasma, as well as the paraoxonase aryl esterase activity in blood plasma and arginase activity in erythrocytes in patients of both groups. Tests to predict the development of postpericardiotomy syndrome were developed based on the ratio of activity of the studied enzymes.
作者简介
V. Vnukov
Southern Federal University
编辑信件的主要联系方式.
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344006
R. Sidorov
Rostov State Medical University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344022
D. Gvaldin
Southern Federal University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344006
N. Milyutina
Southern Federal University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344006
A. Ananyan
Southern Federal University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344006
D. Pospelov
Rostov State Medical University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344022
A. Plotnikov
Southern Federal University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344006
I. Shlyk
Rostov State Medical University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344022
N. Doltmurzieva
Rostov State Medical University
Email: vvvnukov@sfedu.ru
俄罗斯联邦, Rostov-on-Don, 344022