Age-Related Changes in Serine-Arginine Protein Kinase 1 (SRPK1) Content in the Human Dermis

Аннотация

The goal of the present study was to analyze the content of serine-arginine protein kinase 1 (SRPK1) in the human dermis at different ages (from gestational week 20 to 85 years of age). Indirect immunohistochemical detection was used to visualize SRPK1, proliferating cell nuclear antigen (PCNA), and CD 31, an endothelial cell marker, in skin sections. The results showed that the SRPK1 content in the dermal fibroblasts is increased between the antenatal period and 20 years of age and decreased uniformly afterwards (until 61–85 years of age). The SRPK1 content in microcirculation blood vessels of the dermis is increased uniformly between the antenatal period and the age of 61–85 years. Dermis vascularization and the numbers and proliferative activity of fibroblasts was or were decreased steadily between the antenatal period and the age of 61–85 years. The decrease in the SRPK1 content in dermal fibroblasts after 20 years of age occurs concomitantly with the decrease of fibroblast number and proliferative activity. The age-related increase in the SRPK1 content in dermal blood vessels occurs concomitantly with a decrease in vascularization. Therefore, one can assume that SRPK1 exerts dissimilar effects on the proliferation of different dermal components during aging.