Отправить статью по E-mail Oxidative DNA damage in the pathogenesis of chronic obstructive pulmonary disease in older patients
- Авторы: Kytikova O.Y.1, Gvozdenko T.A.1, Vitkina T.I.1
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Учреждения:
- Vladivostok Branch, Far Eastern Scientific Center of Physiology and Pathology of Respiration
- Выпуск: Том 7, № 2 (2017)
- Страницы: 163-165
- Раздел: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205653
- DOI: https://doi.org/10.1134/S2079057017020096
- ID: 205653
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Аннотация
Oxidative stress has long been recognized to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and aging, initiating oxidative damage of biomolecules. This study reveals the development of imbalances in the system of lipid peroxidation and an increase in the level of the marker of oxidative damage to DNA, 8-hydroxy-deoxyguanosine (8-OHdG), in patients with COPD and healthy individuals. Evaluation of the relationship between the parameters of the system of lipid peroxidation and the level of 8-OHdG made it possible to detail different oxidative mechanisms in the pathogenesis of COPD in patients of middle or old age.
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O. Kytikova
Vladivostok Branch, Far Eastern Scientific Center of Physiology and Pathology of Respiration
Автор, ответственный за переписку.
Email: vfdnz@mail.ru
Россия, Vladivostok, 690105
T. Gvozdenko
Vladivostok Branch, Far Eastern Scientific Center of Physiology and Pathology of Respiration
Email: vfdnz@mail.ru
Россия, Vladivostok, 690105
T. Vitkina
Vladivostok Branch, Far Eastern Scientific Center of Physiology and Pathology of Respiration
Email: vfdnz@mail.ru
Россия, Vladivostok, 690105
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