Functional Cumulation of the Influence of Vascular Peptide Bioregulator on Microcirculation in the Brain Cortex of Spontaneously Hypertensive Rats

Abstract

We investigated the influence of the vascular peptide bioregulator on microcirculation in the brain cortex of spontaneously hypertensive rats of different ages and determined whether there was functional cumulation during two applications of the drug Slavinorm by above-mentioned animals. It was shown that a single course treatment with vascular peptide bioregulator had increased the density of the microvascular network of the pia mater in young animals by ~1.2 times and did not affect the perfusion and oxygen saturation of sensorimotor cortex. The second course treatment with Slavinorm was given in six months. Functional cumulation was revealed in 12-month-old rats that had two course treatments with vascular peptide bioregulation: the density of the microvascular network of the pia mater was increased by ~1.6 times; the perfusion level was increased ~15% in comparison with intact animals of the same age. These animals were more tolerant to cerebral vasospasm (the application of vasoconstrictor on the brain surface): the highest level of tissue oxygen saturation was remained at fairly constant perfusion in comparison with other animals.