Dimephosphon radioprotective properties on the model of radiation injury in vivo

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Abstract

Radiation therapy is a commonly used cancer treatment modality. However, its application is limited because of its toxicity to healthy tissue. The search for effective radioprotective agents remains one of the key goals of radiation oncology and radiobiology. This study focuses on experimental modeling of radiation injury in animals and the investigation of Dimephosphon radioprotective properties, a drug exhibiting anti-acidotic, antitumor, and antioxidant activities. It was shown that 14-day administration of the drug at a dose of 750 mg/kg after single-dose (5 Gy) irradiation of CD-1 mice resulted in a local radioprotective effect, reducing the severity of the radiation-induced injury to the intestinal epithelium and splenic capsule. The results of metabolomic screening revealed that the levels of the key metabolites responsible for antioxidant properties such as alpha-tocopherol, nicotinamide riboside, N-carbamoyl-L-aspartate, and adenylosuccinate were significantly increased, indicating that the Dimephosphon drug provides enhanced antioxidant protection.

About the authors

Daria A. Kiseleva

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences

Author for correspondence.
Email: dasha.halikova@mail.ru
ORCID iD: 0000-0002-3932-2491
Russian Federation, Novosibirsk, 630090

Maria A. Melchenko

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences; Novosibirsk State University

Email: almariaand@gmail.com
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090

Olga I. Yarovaya

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences; Novosibirsk State University

Email: oyar@rambler.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090

Nikita V. Basov

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences; Novosibirsk State University

Email: basov@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090

Artem D. Rogachev

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences; Novosibirsk State University

Email: rogachev@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090; Novosibirsk, 630090

Andrey G. Pokrovsky

Novosibirsk State University

Email: a.pokrovskii@g.nsu.ru
Russian Federation, Novosibirsk, 630090

Nariman F. Salakhutdinov

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences

Email: anvar@nioch.nsc.ru
Russian Federation, Novosibirsk, 630090

Tatiana G. Tolstikova

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of Russian Academy of Sciences

Email: tg_tolstikova@mail.ru
ORCID iD: 0000-0002-3750-2958
Russian Federation, Novosibirsk, 630090

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Copyright (c) 2025 Kiseleva D.A., Melchenko M.A., Yarovaya O.I., Basov N.V., Rogachev A.D., Pokrovsky A.G., Salakhutdinov N.F., Tolstikova T.G.

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