mRNA-based personalized cancer vaccines: opportunities, challenges and outcomes

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

mRNA-based cancer vaccines represent an innovative approach to cancer treatment. Cancer mRNA vaccines are structurally based on specific tumor antigens, a technique which enables the patient’s immune system to become activated against cancer cells. Clinical trials of mRNA vaccines against various types of tumors, including melanoma, lung cancer, pancreatic carcinoma, breast cancer and others, are currently underway. Because of their favorable safety profile and adaptability, these therapeutics hold considerable promise in efforts to enhance cancer treatment efficacy and prolong patient life. This review outlines steps in the development of manufacturing technologies for mRNA-based therapeutics, describes the algorithm used to design personalized anti-tumor mRNA vaccines, discusses their practical implementation, and summarizes current clinical trials in cancer immunotherapy.

Авторлар туралы

Arina Ibragimova

Tomsk National Research Medical Center, Russian Academy of Sciences

Email: arina.budnitskaya@gmail.com
ORCID iD: 0009-0003-1728-0723
SPIN-код: 3726-8132
ResearcherId: NPJ-0555-2025

Cancer Research Institute

Ресей, Tomsk, 634009

Anton Fedorov

Tomsk National Research Medical Center, Russian Academy of Sciences

Email: anton.fedorov.2014@mail.ru
ORCID iD: 0000-0002-5121-2535
Scopus Author ID: 57211136209

Cancer Research Institute

Ресей, Tomsk, 634009

Kirill Kirilenko

Tomsk National Research Medical Center, Russian Academy of Sciences

Email: kirillkirilenko.tomsk@gmail.com
ORCID iD: 0009-0005-5208-2495

Center for Systems Bioinformatics

Ресей, Tomsk, 634050

Evgeny Choynzonov

Tomsk National Research Medical Center, Russian Academy of Sciences

Email: choinzonov.el@ssmu.ru
ORCID iD: 0000-0002-3651-0665
SPIN-код: 2240-8730
Scopus Author ID: 6603352329
ResearcherId: C-9892-2012

Cancer Research Institute

Ресей, Tomsk, 634009

Evgeny Denisov

Tomsk National Research Medical Center, Russian Academy of Sciences

Email: d_evgeniy@oncology.tomsk.ru
ORCID iD: 0000-0003-2923-9755
Scopus Author ID: 26653961800
ResearcherId: C-8662-2012

Cancer Research Institute

Ресей, Tomsk, 634009

Marina Patysheva

Tomsk National Research Medical Center, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: patysheva_mr@onco.tnimc.ru
ORCID iD: 0000-0003-2865-7576
Scopus Author ID: 57200569624
ResearcherId: Q-9364-2017

Cancer Research Institute

Ресей, Tomsk, 634009

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