Biochemical markers of neurodegeneration in patients with cerebral small vessel disease and Alzheimer's disease
- 作者: Dobrynina L.1, Tsypushtanova M.1, Shabalina А.1, Shamtieva K.1, Makarova A.1, Trubitsyna V.1, Bitsieva E.1, Byrochkina A.1, Geints A.2
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隶属关系:
- Research Center of Neurology
- Lomonosov Moscow State University
- 期: 卷 17, 编号 3 (2023)
- 页面: 21-30
- 栏目: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/253952
- DOI: https://doi.org/10.54101/ACEN.2023.3.3
- ID: 253952
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Introduction. Cerebral small vessel disease (CSVD) as well as the Alzheimer's disease (AD) and their comorbidities are the most common causes of cognitive impairments (CIs).
Objective: to evaluate the predictive power of the biochemical neurodegeneration markers in patients with CSVD and AD.
Materials and methods. We assessed the following neurodegeneration markers in 68 patients with CSVD (61.0 ± 8.6 years; 60.3% males), 17 patients with AD (65.2 ± 8.3 years; 35.3% males), and 26 healthy volunteers (59.9 ± 6.7 years; 38.5% males): neuron-specific enolase (NSE), glial fibrillary acid protein (GFAP), neurofilament light polypeptide (NEFL) in blood (for all patients) and in cerebrospinal fluid (CSF; in patients with CSVD and AD). We assessed the predictive power of those markers with ROC analysis.
Results. As compared to the control group, serum GFAP in patients with CSVD showed its predictive power at 0.155 ng/ml (sensitivity 74%; specificity 70%). Serum NEFL > 0.0185 ng/ml (sensitivity 82%; specificity 96%) and NSE < 4.95 μg/ml (sensitivity 77%; specificity 71%) showed their predictive power in patients with AD. CSF GFAP > 1.03 ng/ml (sensitivity 84%; specificity 88%), CSF NSE < 19.10 μg/ml (sensitivity 88%; specificity 91%), serum NEFL < 0.021 ng/ml (sensitivity 71%; specificity 76%), serum NSE /CSF NSE ratio > 0.273 ng/ml (sensitivity 87%; specificity 88%) help differentiate CSVD from AD.
Conclusions. We found that serum GFAP can be a useful diagnostic marker in patients with CSVD, while serum NEFL and serum NSE can help identify the AD. In addition, CSF GFAP and CSF NSE as well as serum NEFL and serum NSE/CSF NSE can help differentiate CSVD from AD. We can use those markers in clinical and research practice to identify the vascular and neurodegenerative causes of CIs and their comorbidities, which is of a great importance in developing specific treatment and predicting the course of the disease.
作者简介
Larisa Dobrynina
Research Center of Neurology
Email: dobrla@mail.ru
ORCID iD: 0000-0001-9929-2725
D. Sci. (Med.), chief researcher, Head, 3rd Neurological department, Institute of Clinical and Preventive Neurology, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowMaria Tsypushtanova
Research Center of Neurology
Email: tzipushtanova@mail.ru
ORCID iD: 0000-0002-4231-3895
postgraduate student, neurologist, 3rd Neurological department, Institute of Clinical and Preventive Neurology, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowАlla Shabalina
Research Center of Neurology
Email: ashabalina@yandex.ru
ORCID iD: 0000-0001-9604-7775
D. Sci. (Med.), leading researcher, Head, Department of laboratory diagnostics, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowKamila Shamtieva
Research Center of Neurology
Email: kamila.shamt@gmail.com
ORCID iD: 0000-0002-6995-1352
Cand. Sci. (Med.), researcher, 3rd Neurological department, Institute of Clinical and Preventive Neurology, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowAngelina Makarova
Research Center of Neurology
Email: angelinagm@mail.ru
ORCID iD: 0000-0001-8862-654X
postgraduate student, neurologist, 3rd Neurological department, Institute of Clinical and Preventive Neurology, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowViktoria Trubitsyna
Research Center of Neurology
Email: pobeda-1994@mail.ru
ORCID iD: 0000-0001-7898-6541
postgraduate student, radiologist, Department of radiation diagnostics, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowElina Bitsieva
Research Center of Neurology
Email: elinabitsieva1997@mail.ru
ORCID iD: 0000-0003-1464-0722
postgraduate student, neurologist, 3rd Neurological department, Institute of Clinical and Preventive Neurology, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowAleksandra Byrochkina
Research Center of Neurology
Email: byrochkinasasha@mail.ru
ORCID iD: 0000-0002-2285-2533
postgraduate student, neurologist, 3rd Neurological department, Institute of Clinical and Preventive Neurology, Research Center of Neurology, Moscow, Russia
俄罗斯联邦, MoscowAnastasia Geints
Lomonosov Moscow State University
编辑信件的主要联系方式.
Email: anastasiyatarasova75@gmail.com
ORCID iD: 0009-0001-1836-2515
resident of the 6rd neurological department of the Research Center of Neurology
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