The Parkinson’s disease (PD) pathology is not limited by degeneration of the nigrostriatal dopaminergic system, but includes also wide involvement of different regions of cerebral cortex. The aim of this study was the identification of differences in the brain cortical thickness in patients with early and advanced PD with the use of MRI morphometry. Sixty seven PD patients with Hoehn-Yahr 2 and 3 stages were examined. All patients underwent MRI with subsequent post-processing and receiving of cortical thickness parameters in different brain regions. Significant differences in the visual cortex, the cingulated and fusiform gyri and the frontopolar zone of a dominant hemisphere, and the Brodmann’s areas 1, 2, 3 and 4 of a non-dominant hemisphere were obtained. These data allow revealing relationships between non-motor manifestations of PD and degeneration of certain cortical regions of the brain.
Cortical cerebral atrophy in patients with Parkinson’s disease: new trends in the diagnostics in vivo
- 作者: Trufanov A.1, Litvinenko I.1, Odinak M.1, Voronkov L.2, Khaimov D.2, Efimzev A.2, Fokin V.2
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隶属关系:
- S.M. Kirov Military Medical Academy
- Military Medical Academy named after S.M. Kirov
- 期: 卷 7, 编号 3 (2013)
- 页面: 37-41
- 栏目: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124582
- DOI: https://doi.org/10.17816/psaic228
- ID: 124582
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作者简介
Artem Trufanov
S.M. Kirov Military Medical Academy
编辑信件的主要联系方式.
Email: trufanovart@gmail.com
俄罗斯联邦, St. Petersburg
Igor Litvinenko
S.M. Kirov Military Medical Academy
Email: trufanovart@gmail.com
俄罗斯联邦, St. Petersburg
Miroslav Odinak
S.M. Kirov Military Medical Academy
Email: trufanovart@gmail.com
俄罗斯联邦, St. Petersburg
L. Voronkov
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
俄罗斯联邦, St.-Petersburg
D. Khaimov
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
俄罗斯联邦, St.-Petersburg
A. Efimzev
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
俄罗斯联邦, St.-Petersburg
V. Fokin
Military Medical Academy named after S.M. Kirov
Email: trufanovart@gmail.com
俄罗斯联邦, St.-Petersburg
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