Neuropsychological abnormalities in early-stage Parkinson’s disease
- Authors: Vereyutina I.A.1, Illarioshkin S.N.2, Zhuravleva E.Y.3, Shikhkerimov R.K.1
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Affiliations:
- Neurological Department of Municipal Outpatients’ Clinic № 26, South Administrative District
- Research Center of Neurology
- Medical Department, Administration of President of the Russian Federation
- Issue: Vol 6, No 2 (2012)
- Pages: 11-15
- Section: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124525
- DOI: https://doi.org/10.17816/psaic276
- ID: 124525
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Full Text
Abstract
Comparative assessment of affective and cognitive abnormalities in different clinical forms of early-stage Parkinson’s disease (PD) was performed. In the majority of patients, cognitive decline of predominantly executive and neurodynamic type not reaching the dementia level was registered. The revealed cognitive disturbances prevailed in patients with an akinetic-rigid form of PD, while a trembling form turned out more benign from the viewpoint of its influence on the intellectual sphere. High prevalence of depression on early-stage PD was shown: depressive symptoms of various severities were observed in 84% examined patients. By analogy with cognitive decline, depression and anxiety at the debut of PD were significantly more frequent in patients with an akinetic-rigid form compared to a trembling phenotype. These data confirm that affective disturbances are very characteristic early (including premotor) manifestations of PD.
About the authors
I. A. Vereyutina
Neurological Department of Municipal Outpatients’ Clinic № 26, South Administrative District
Author for correspondence.
Email: vereyutina@mail.ru
Russian Federation, Moscow
Sergey N. Illarioshkin
Research Center of Neurology
Email: vereyutina@mail.ru
ORCID iD: 0000-0002-2704-6282
D. Sci. (Med.), Prof., Corr. Member of the Russian Academy of Sciences, Deputy Director, Head, Department for brain research
Russian Federation, MoscowE. Yu. Zhuravleva
Medical Department, Administration of President of the Russian Federation
Email: vereyutina@mail.ru
Russian Federation, Moscow
R. K. Shikhkerimov
Neurological Department of Municipal Outpatients’ Clinic № 26, South Administrative District
Email: vereyutina@mail.ru
Russian Federation, Moscow
References
- Вейн А.М., Вознесенская Т.Г., Голубев В.Л., Дюкова Г.М. Депрессия в неврологической практике (клиника, диагностика, лечение). М.: МИА, 2002.
- Вендрова М.И., Голубев В.Л., Садеков Р.А., Вейн А.М. Двигательные, когнитивные и аффективные расстройства при болезни Паркинсона. Журн. неврол. и психиатрии им. С.С. Корсакова 2002; 3: 13–17.
- Иллариошкин С.Н. Немоторные проявления болезни Паркинсона. Нервы 2007; 1: 7–8 .
- Левин О.С., Докадина Л.В. Эпидемиология паркинсонизма и болезни Паркинсона. Неврол. журн. 2005; 5: 41–49.
- Лурия А.Р. Основы нейропсихологии. М.: МГУ, 1973.
- Реброва О.Ю. Статистический анализ медицинских данных. Применение пакета прикладных программ STATISTICA. М.: МедиаСфера, 2006.
- Федорова Н.В., Мирецкая А.В., Кулуа Т.К. Депрессия и тревога при болезни Паркинсона. Трудный пациент 2006; 7: 11–13 .
- Экстрапирамидные расстойства. Руководство по диагностике и лечению (под ред. В.Н. Штока, И.А. Ивановой-Смоленской, О.С. Левина). М.: МЕДпресс-информ, 2002.
- Aarsland D., Karlsen K. Neuropsychiatric aspects of Parkinsonґs disease. Curr. Psychiatry. Rep. 1999; 1: 61–68.
- Burn D.J. Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson’s disease. Mov. Disord. 2002; 17: 445–454.
- Chaudhuri K.R., Healy D.J., Schapira A.H.V. Non-motor symptoms of Parkinson’s disease: diagnosis and management. Lancet Neurol. 2006; 5; 235–245.
- Cubo E., Bernard B., Leurgans S., Raman R. Cognitive and motor fanction in patients with Parkinsonґs disease with and without depression. Clin. Neuropharmacol. 2000; 23; 331–334.
- Errea J.M., Ara J.R. Depression and Parkinson disease. Rev. Neurol. 1999; 28: 694–698.
- Guttman M., Slaughter P.M., Theriault M.E. et al. Burden of parkinsonism: a population-based study. Mov. Disord. 2003; 18: 313–319.
- Happe S., Schrodl B., Faltl M., Muller C. Sleep disorders and depression in patients with Parkinson’s disease. Acta Neurol. Scand. 2001; 104: 275–280.
- Mayeux R., Stern Y., Rosen S., Leventhal J. Depression, intellectual impairment, and Parkinson disease. Neurology 1981; 31: 645–650.
- Polich J., Kok A. Cognitive and biological determinants of P300: an integrative review. Biol. Psychol. 1995; 41: 103–146.
- Slaughter J.R., Slaughter K.A., Nichols D. et al. Prevalence, clinical manifestations, etiology, and treatment of depression in Parkinson’s disease. J. Neuropsychiatry Clin. Neurosci. 2001; 13: 187–196. 19.Wolters E.Ch., Bergmans P. Preclinical (premotor) Parkinson’s disease. J. Neurol. 2000; 247: 103–109.
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