Key Risk Factors for Intracerebral Hemorrhage According to Regional Population-Based Stroke Registry

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Abstract

Introduction. Intracerebral hemorrhage (ICH) registry data allow assessing epidemiological parameters and risk factors in different age, gender, race, ethnicity, and other subgroups.

This study aimed to evaluate the prevalence of key risk factors in a group of Yakutsk residents with primary hypertensive ICH included in the regional population-based stroke registry from 2015 to 2017.

Materials and methods. This study of risk factors was conducted in patients with hypertensive ICH (n = 251) from the regional population-based stroke registry, including 133 (53%) men and 118 (47%) women of Asian or Caucasian races. We performed statistical analysis of data.

Results. The analysis of risk factors showed that the prevalence of smoking and excessive alcohol consumption was higher in men with ICH compared with women (p < 0.001). There were no statistically significant differences in the incidence of hypertension, history of myocardial infarction, dyslipidemia, or diabetes mellitus in patients with ICH in gender or ethnicity subgroups. Fibrillation and other heart diseases were more common in Caucasian patients than in Asian (p = 0.005). ICH was associated with high levels of low-density lipoproteins and triglycerides with low levels of total cholesterol and high-density lipoproteins compared with healthy individuals.

Conclusions. We described gender and ethnic differences in the prevalence of risk factors in patients with hypertensive ICH.

About the authors

Marina Yu. Maksimova

Research Center of Neurology

Author for correspondence.
Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-7682-6672

D. Sci (Med), Prof., Head of the 2nd Neurology Department, Institute of Clinical and Preventive Neurology

Russian Federation, Moscow

Sargylana A. Chugunova

North-Eastern Federal University named after M.K. Ammosov

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-2019-2455

Cand. Sci. (Med.), Associated Professor

Russian Federation, Yakutsk

References

  1. Инсульт: современные технологии диагностики и лечения / под ред. М.А. Пирадова, М.М. Танашян, М.Ю. Максимовой. М.; 2018. 360 с. Piradov M.A., M.M. M.Yu. Maksimova (eds.) Stroke: modern technologies for diagnosis and treatment Moscow; 2018. 360 p.
  2. Суслина З.А., Гулевская Т.С., Максимова М.Ю., Моргунов В.А. Нарушения мозгового кровообращения: диагностика, лечение, профилактика. М.; 2016. 536 с. Suslina Z.A., Gulevskaya T.S., Maksimova M.Yu., Morgunov V.A. Cerebral circulation disorders: diagnosis, treatment, prevention. Moscow; 2016. 536 p.
  3. Zia E., Hedblad B., Pessah-Rasmussen H. et al. Blood pressure in relation to the incidence of cerebral infarction and intracerebral hemorrhage. Hypertensive hemorrhage: debated nomenclature is still relevant. Stroke. 2007;38(10):2681–2685. doi: 10.1161/STROKEAHA.106.479725
  4. Martini S.R., Flaherty M.L., Brown W.M. et al. Risk factors for intracerebral hemorrhage differ according to hemorrhage location. Neurology. 2012;79(23):2275–2282. doi: 10.1212/WNL.0b013e318276896f
  5. Chen Y.W., Li C.H., Yang C.D. et al. Low cholesterol level associated with severity and outcome of spontaneous intracerebral hemorrhage: results from Taiwan Stroke Registry. PLoS One. 2017;12(4):e0171379. doi: 10.1371/journal.pone.0171379
  6. Yaghi S., Elkind M.S. Lipids and cerebrovascular disease: research and practice. Stroke. 2015;46(11):3322–3328. doi: 10.1161/STROKEAHA.115.011164
  7. Suh I., Jee S.H., Kim H.C. et al. Low serum cholesterol and haemorrhagic stroke in men: Korea Medical Insurance Corporation Study. Lancet. 2001;357(9260):922–925. doi: 10.1016/S0140-6736(00)04213-6
  8. Tsai C.F., Jeng J.S., Anderson N., Sudlow C.L.M. Comparisons of risk factors for intracerebral hemorrhage versus ischemic stroke in Chinese patients. Neuroepidemiology. 2017;48(1-2):72–78. doi: 10.1159/000475667
  9. Smeeton N.C., Heuschmann P.U., Rudd A.G. et al. Incidence of hemorrhagic stroke in black Caribbean, black African, and white populations: the South London stroke register, 1995-2004. Stroke. 2007;38(12):3133–3138. doi: 10.1161/STROKEAHA.107.487082
  10. Springer M.V., Schmidt J.M., Wartenberg K.E. et al. Predictors of global cognitive impairment 1 year after subarachnoid hemorrhage. Neurosurgery. 2009;65(6):1043–1051. doi: 10.1227/01.NEU.0000359317.15269.20
  11. He W., Liu Y., Feng J. et al. The epidemiological characteristics of stroke in Hunan Province, China. Front. Neurol. 2018;9:583. doi: 10.3389/fneur.2018.00583
  12. Khan N.A., Quan H., Hill M.D. et al. Risk factors, quality of care and prognosis in South Asian, East Asian and White patients with stroke. BMC Neurol. 2013;13:74. doi: 10.1186/1471-2377-13-74
  13. Третьякова Н.Н., Варакин Ю.Я., Кузьмина З.M. и др. Клинико-эпидемиологическое исследование инсульта в городе Якутске. Анналы клинической и экспериментальной неврологии. 2008;2(2):18–22. Tretyakova N.N., Varakin Y.Y., Kuzmina Z.M. et al. Сlinical-epidemiological study of stroke in the city of Yakutsk. Annals of Clinical and Experimental Neurology. 2008;2(2):18–22.
  14. Chugunova S.A., Nikolaeva T.Y. The ethnic differences of stroke in Yakutia. Int. J. Circumpolar. Health. 2013;72. doi: 10.3402/ijch.v72i0.21221
  15. Unnithan A.K.A., M Das J., Mehta P. Hemorrhagic Stroke. 2023 May 8. In: StatPearls [Internet]. Treasure Island; 2023.
  16. Virani S.S., Alonso A., Benjamin E.J. et al. Heart Disease and Stroke Statistics-2020 Update: a report from the American Heart Association. Circulation. 2020;141(9):e139–e596. doi: 10.1161/CIR.0000000000000757
  17. An S.J., Kim T.J., Yoon B.W. Epidemiology, risk factors, and clinical features of intracerebral hemorrhage: an update. J. Stroke. 2017;19(1):3–10. doi: 10.5853/jos.2016.00864
  18. Poon M.T., Bell S.M., Al-Shahi Salman R. Epidemiology of intracerebral haemorrhage. Front. Neurol. Neurosci. 2015;37:1–12. doi: 10.1159/000437109
  19. Cordonnier C., Demchuk A., Ziai W., Anderson C.S. Intracerebral haemorrhage: current approaches to acute management. Lancet. 2018;392(10154): 1257–1268. doi: 10.1016/S0140-6736(18)31878-6
  20. Lovelock C.E., Molyneux A.J., Rothwell P.M.; Oxford Vascular Study. Change in incidence and aetiology of intracerebral haemorrhage in Oxfordshire, UK, between 1981 and 2006: a population-based study. Lancet Neurol. 2007;6(6):487–493. doi: 10.1016/S1474-4422(07)70107-2
  21. Cho S., Rehni A.K., Dave K.R. Tobacco use: a major risk factor of intracerebral hemorrhage. J. Stroke. 2021;23(1):37–50. doi: 10.5853/jos.2020.04770
  22. Feldmann E., Broderick J.P., Kernan W.N. et al. Major risk factors for intracerebral hemorrhage in the young are modifiable. Stroke. 2005;36(9):1881–1885. doi: 10.1161/01.STR.0000177480.62341.6b
  23. Zou Y., Zhang C., Ge H. et al. Comparison of epidemiological and clinical features between two chronological cohorts of patients with intracerebral hemorrhage. J. Clin. Neurosci. 2020;72:169–173. doi: 10.1016/j.jocn.2019.12.031
  24. George J., Rapsomaniki E., Pujades-Rodriguez M. et al. How does cardiovascular disease first present in women and men? Incidence of 12 cardiovascular diseases in a contemporary cohort of 1,937,360 people. Circulation. 2015;132(14):1320–1328. doi: 10.1161/CIRCULATIONAHA.114.013797
  25. Honjo K., Iso H., Tsugane S. et al. The effects of smoking and smoking cessation on mortality from cardiovascular disease among Japanese: pooled analysis of three large-scale cohort studies in Japan. Tob. Control. 2010;19(1):50–57. doi: 10.1136/tc.2009.029751
  26. Bharosay A., Bharosay V.V., Bandyopadhyay D. et al. Effect of lipid profile upon prognosis in ischemic and haemorrhagic cerebrovascular stroke. Indian J. Clin. Biochem. 2014;29(3):372–376. doi: 10.1007/s12291-013-0372-6
  27. Yi S.W., Shin D.H., Kim H. et al. Total cholesterol and stroke mortality in middle-aged and elderly adults: a prospective cohort study. Atherosclerosis. 2018;270:211–217. doi: 10.1016/j.atherosclerosis.2017.12.003
  28. Пирадов М.А., Танашян М.М., Домашенко М.А. и др. Нейропротекция при цереброваскулярных заболеваниях: поиск жизни на Марсе или перспективное направление лечения? Часть 1. Острые нарушения мозгового кровообращения. Анналы клинической и экспериментальной неврологии. 2015;9(1):41–50. Piradov M.A., Tanashyan M.M., Domashenko M.A. et al. Neuroprotection in cerebrovascular diseases: is it the search for life on Mars or a promising trend of treatment? Part 1. Acute stroke. Annals of Clinical and Experimental Neurology. 2015;9(1):41–50.
  29. Танашян М.М., Орлов С.В., Домашенко М.А., Ионова В.Г. Метаболический синдром и ишемический инсульт. Анналы клинической и экспериментальной неврологии. 2007;1(3):5–11. Tanashyan M.M., Orlov S.V., Domashenko M.A., Ionova V.G. Metabolic syndrome and ischemic stroke. Annals of Clinical and Experimental Neurology. 2007;1(3):5–11.
  30. Lučić Prokin A., Čuzdi A., Zivanović Z. et al. Dyslipidemia as risk factor for primary intracerebral hemorrhage. Med. Glas (Zenica). 2014;11(1):31–36.
  31. Valappil A.V., Chaudhary N.V., Praveenkumar R. et al. Low cholesterol as a risk factor for primary intracerebral hemorrhage: a case-control study. Ann. Indian Acad. Neurol. 2012;15(1):19–22. doi: 10.4103/0972-2327.93270
  32. Xu C., Zarins C.K., Glagov S. Aneurysmal and occlusive atherosclerosis of the human abdominal aorta. J. Vasc. Surg. 2001;33(1):91–96. doi: 10.1067/mva.2001.109744

Copyright (c) 2024 Maksimova M.Y., Chugunova S.A.

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