Long-Term Outcomes of Management of Inferior Alveolar Neuropathy Following Orthognatic Surgeries in Patients with Mandibular Anomalies and Deformities

Cover Page

Cite item

Full Text

Abstract

Introduction. Orthognatic surgery is a routine method to manage mandibular anomalies and deformities.

Objective: To assess long-term outcomes of rhythmic peripheral magnetic stimulation (rPMS) in patients with neuropathy of the inferior alveolar nerve (IAN) resulting from the surgical treatment of mandibular anomalies and deformities.

Materials and methods. The study included 8 males and 16 females aged 32 ± 12 years with IAN neuropathy following the surgical treatment of mandibular anomalies and deformities. Therapeutic rPMS was performed with the Neuro-MS magnetic stimulator (Neurosoft, Ivanovo, Ivanovo Region, Russian Federation). Trigeminal and brainstem acoustic evoked potentials (EPs) were registered with Neuro-MVP (Neurosoft) to assess rPMS both at baseline (in 10 days) and in long term (in 18 ± 2 months).

Results. Sensory disorders and pain prevailed in postoperative IAN neuropathy. Sensory disorders improved in 20 patients following 10-day rPMS. The clinical effect persisted in re-assessment. In long term, acoustic brainstem EPs normalized and trigeminal EPs did not change negatively.

Conclusion. The use of rPMS in IAN neuropathy following orthognatic surgeries contributes to the functional improvement and stabilization of the peripheral and central brainstem and the trigeminal system.

About the authors

Marine M. Tanashyan

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-5883-8119

D. Sci (Med.), Prof., Deputy Director for Scientific Research Work, Head, 1st Neurology Department, Institute of Clinical and Preventive Neurology

Russian Federation, Moscow

Marina Yu. Maximova

Research Center of Neurology; A.I. Evdokimov Moscow State University of Medicine and Dentistry, Ministry of Health of Russia

Author for correspondence.
Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-7682-6672

D. Sci (Med.), Prof., Head, 2nd Neurology Department, Institute of Clinical and Preventive Neurology, Research Center of Neurology; Professor, Department of Nervous Diseases, A.I. Evdokimov Moscow State University of Medicine and Dentistry

Russian Federation, Moscow; Moscow

Pavel A. Fedin

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0001-9907-9393

Cand. Sci (Med.), Leading Researcher, Laboratory of Clinical Neurophysiology

Russian Federation, Moscow

Tatiana Yu. Noskova

Research Center of Neurology

Email: ncnmaximova@mail.ru
ORCID iD: 0000-0002-1634-1497

Cand. Sci (Med.), Senior Researcher, Scientific and Consulting Department

Russian Federation, Moscow

References

  1. Agbaje J.O., Salem A.S., Lambrichts I. et al. Systematic review of the incidence of inferior alveolar nerve injury in bilateral sagittal split osteotomy and the assessment of neurosensory disturbances. Int. J. Oral Maxillofac. Surg 2015;44:447–451. doi: 10.1016/j.ijom.2014.11.010
  2. Degala S., Shetty S.K., Bhanumathi M. Evaluation of neurosensory disturbance following orthognathic surgery: a prospective study. J. Maxillofac. Oral Surg 2015;14: 24–31. doi: 10.1007/s12663-013-0577-5
  3. Robert R.C., Bacchetti P., Pogrel M.A. Frequency of trigeminal nerve injuries following third molar removal. J. Oral Maxillofac. Surg 2005;63:732–735. doi: 10.1016/j.joms.2005.02.006
  4. Politis C., Sun Y., Lambrichts I., Agbaje J.O. Self-reported hypoesthesia of the lower lip after sagittal split osteotomy. Int. J. Oral Maxillofac. Surg. 2013;42:823–829. doi: 10.1016/j.ijom.2013.03.020
  5. Yamauchi K., Takahashi T., Kaneuji T. et al. Risk factors for neurosensory disturbance after bilateral sagittal split osteotomy based on position of mandibular canal and morphology of mandibular angle. J. Oral Maxillofac. Surg. 2011;70:401–406. doi: 10.1016/j.joms.2011.01.040
  6. Wijbenga J.G., Verlinden C.R., Jansma J. et al. Long-lasting neurosensory disturbance following advancement of the retrognathic mandible: distraction osteogenesis versus bilateral sagittal split osteotomy. Int. J. Oral Maxillofac. Surg. 2009;38:719–725. doi: 10.1016/j.ijom.2009.03.714
  7. Carballo Cuello C.M., De Jesus O. Neurapraxia. In: StatPearls.Treasure Island; 2023.
  8. Teerijoki-Oksa T., Jääskeläinen S.K., Soukka T. et al. Subjective sensory symptoms associated with axonal and demyelinating nerve injuries after mandibular sagittal split osteotomy. Oral Maxillofac. Surg. 2011;69(6):e208–e213. doi: 10.1016/j.joms.2011.01.024
  9. Korczeniewska O.A., Kohli D., Benoliel R. et al. pathophysiology of post-traumatic trigeminal neuropathic pain. Biomolecules. 2022;12(12):1753. doi: 10.3390/biom12121753
  10. Танашян М.М., Максимова М.Ю., Федин П.А. и др. Диагностика и лечение травматичеcкой невропатии тройничного нерва. Анналы клинической и экспериментальной неврологии 2018;12(2):22–26. Tanashyan M.M., Maximova M.Yu., Fedin P.A. et al. Diagnosis and management of traumatic neuropathy. Annals of clinical and experimental neurology. 2018;12(2):22–26 doi: 10.18454/ACEN.2018.2.3
  11. D'Agostino A., Trevisiol L., Gugole F. et al. Complications of orthognathic surgery: the inferior alveolar nerve. J. Craniofac. Surg. 2010;21(4):1189–1195. doi: 10.1097/SCS.0b013e3181e1b5ff
  12. Guerra A, López-Alonso V, Cheeran B, Suppa A. Variability in non-invasive brain stimulation studies: Reasons and results. Neurosci. Lett. 2020;719:133330. doi: 10.1016/j.neulet.2017.12.058
  13. Пойдашева А.Г., Синицын Д.О., Бакулин И.С. и др. Структурные и функциональные биомаркеры эффекта навигационной ритмической транскраниальной магнитной стимуляции у пациентов с фармакорезистентной депрессией. Неврология, нейропсихиатрия, психосоматика. 2022;14(4):12–19. Poydasheva A.G., Sinitsyn D.O., Bakulin I.S. et al. Structural and functional biomarkers of the effect of navigational repetitive transcranial magnetic stimulation in patients with drug-resistant depression. Neurology, Neuropsychiatry, Psychosomatics. 2022;14(4):12–19. doi: 10.14412/2074-2711-2022-4-12-19
  14. Struppler A., Angerer B., Gundisch C., Havel P. Modulatory effect of repetitive peripheral magnetic stimulation on skeletal muscle tone in healthy subjects stabilization of the elbow joint. Exp. Brain Res. 2004;157(1):59–66. doi: 10.1007/s00221-003-1817-6
  15. Золотухина Е.И, Улащик В.С. Основы импульсной магнитотерапии: пособие. Витебск; 2012. 144 с. Zolotukhina E.I., Ulashchik V.S. Fundamentals of pulsed magnetotherapy: a manual. Vitebsk; 2012. 144 p.
  16. Krause P., Straube A. Peripheral repetitive magnetic stimulation induces intracortical inhibition in healthy subjects. Neurol. Res. 2008;30(7):690–694. doi: 10.1179/174313208X297959
  17. Меркулов Ю.А., Гореликов А.Е., Пятков А.А., Меркулова Д.М. Ритмическая трансспинальная магнитная стимуляция в терапии хронической боли в нижней части спины. Метаанализ (Часть II). Патологическая физиология и экспериментальная терапия. 2021;65(4):97–108. Merkulov Y.A., Gorelikov A.E., Pyatkov A.A., Merkulova D.M. Repetitive transspinal magnetic stimulation in the treatment of chronic low back pain. A meta-analysis (Part II). Pathological Physiology and Experimental Therapy, Russian Journal. 2021;65(4):97–108. doi: 10.25557/0031-2991.2021.04.97-108
  18. Khedr E.M., Ahmed M.A., Alkady E.A. et al. Therapeutic effects of peripheral magnetic stimulation on traumatic brachial plexopathy: clinical and neurophysiological study. Neurophysiol. Clin. 2012;42(3):111–118. doi: 10.1016/j.neucli.2011.11.003
  19. Stidd D.A., Wuollet A.L., Bowden K. et al. Peripheral nerve stimulation for trigeminal neuropathic pain. Pain Physician. 2012;15(1):27–33.
  20. Мусаев А.В., Гусейнова С.Г., Мустафаева Э.Э. Высокоинтенсивная магнитная стимуляция в реабилитации больных с травматическими поражениями нервов верхних конечностей. Физиотерапия, бальнеология и реабилитация 2010;3:14–17. Musaev A.V., Huseynova S.G., Mustafayeva E.E. High-intensity magnetic stimulation in the rehabilitation of patients with traumatic lesions of the nerves of the upper extremities. Physiotherapy, balneology and rehabilitation. 2010;3:14–17.
  21. Mert T., Gunay I., Gocmen C. et al. Regenerative effects of pulsed magnetic field on injured peripheral nerves. Altern. Ther. Health Med. 2006;12(5):42–49.
  22. Танашян М.М., Максимова М.Ю., Иванов С.Ю. и др. Невропатия тройничного нерва после ортогнатических операций. Неврология, нейропсихиатрия, психосоматика. 2020;12(4):37–42. Tanashyan M.M., Maksimova M.Yu., Ivanov S.Yu. et al. Trigeminal neuropathy following orthognathic surgery. Neurology, Neuropsychiatry, Psychosomatics. 2020;12(4):37–42. doi: 10.14412/2074-2711-2020-4-37-42
  23. Максимова М.Ю., Федин П.А., Суанова Е.Т., Тюрников В.М. Нейрофизиологические особенности атипичной лицевой боли. Анналы клинической и экспериментальной неврологии. 2013;7(3):9–16. Maksimova M.Yu., Fedin P.A., Suanova E.T., Tyurnikov V.M. [Neurophysiological features of atypical facial pain. Annals of clinical and experimental neurology. 2013;7(3):9–16.
  24. Jiang Y.F., Zhang D., Zhang J. et al. A randomized controlled trial of repetitive peripheral magnetic stimulation applied in early subacute stroke: effects on severe upper-limb impairment. Clin. Rehabil. 2022;36(5):693–702. doi: 10.1177/02692155211072189
  25. Gallasch E., Christova M., Kunz A. et al. Modulation of sensorimotor cortex by repetitive peripheral magnetic stimulation. Front. Hum. Neurosci. 2015;9:407. doi: 10.3389/fnhum.2015.00407
  26. Fan Z., Wen X., Ding X. et al. Advances in biotechnology and clinical therapy in the field of peripheral nerve regeneration based on magnetism. Front. Neurol. 2023;14:1079757. doi: 10.3389/fneur.2023.1079757
  27. Rosen A.D. Mechanism of action of moderate-intensity static magnetic fields on biological systems. Cell Biochem. Biophys. 2003;39(2):163–173. doi: 10.1385/CBB:39:2:163
  28. Mathie A., Kennard L.E., Veale E.L. Neuronal ion channels and their sensitivity to extremely low frequency weak electric field effects. Radiat. Prot. Dosimetry. 2003;106(4):311–316. doi: 10.1093/oxfordjournals.rpd.a006365
  29. Marchionni I., Paffi A., Pellegrino M. et al. Comparison between low-level 50 Hz and 900 MHz electromagnetic stimulation on single channel ionic currents and on firing frequency in dorsal root ganglion isolated neurons. Biochim. Biophys. Acta 2006;1758(5):597–605. doi: 10.1016/j.bbamem.2006.03.014
  30. Saunders R.D., Jefferys J.G.R. A neurobiological basis for ELF guidelines. Health Phys. 2007;929(6):596–603. doi: 10.1097/01.HP.0000257856.83294.3e
  31. Lin T.C., Lin F.H., Lin J.C. In vitro feasibility study of the use of a magnetic electrospun chitosan nanofiber composite for hyperthermia treatment of tumor cells. Acta Biomater. 2012;8:2704–2711. doi: 10.1016/j.actbio.2012.03.045
  32. Cancalon P. Influence of temperature on various mechanisms associated with neuronal growth and nerve regeneration. Prog. Neurobiol. 1985;25(1):27–92. doi: 10.1016/0301-0082(85)90022-x

Copyright (c) 2023 Tanashyan M.M., Maximova M.Y., Fedin P.A., Noskova T.Y.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies