Role of Inflammatory Mediators, Growth Factors, and Osteodystrophy in Recurrent Lumbar Disk Herniation
- Authors: Chekhonatskiy V.A.1, Dreval O.N.1, Kuznetsov A.V.1, Chekhonatskiy A.A.2, Zakharova N.B.2, Grishina E.A.1, Gorozhanin A.V.3, Volna V.V.3
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Affiliations:
- Russian Medical Academy of Continuous Professional Education
- Saratov State Medical University named after V.I. Razumovsky
- S.P. Botkin City Clinical Hospital
- Issue: Vol 17, No 2 (2023)
- Pages: 36-42
- Section: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/131727
- DOI: https://doi.org/10.54101/ACEN.2023.2.5
- ID: 131727
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Abstract
Introduction. Reintervention in patients with spinal disk herniation is shown to significantly decrease likelihood of favorable outcomes in the postoperative period. Thus, it is important to individually assess risk factors for and likelihood of spinal disk herniation recurrence for each patient, and choose a suitable surgical option.
Objective: to evaluate changes in the levels of immunoregulatory mediators in the blood serum and extracted spinal disc tissue of allegedly healthy individuals and patients with lumbar disk herniation relapses.
Materials and methods. We examined 60 patients. The control group included 19 patients with traumatic spinal cord injuries at the lumbar level. The main group included 41 patients with spinal disk herniation. Twenty-two individuals had primary herniation while 11 patients presented with single clinical and neurological relapses at the pre-operated lumbar level and 8 patients presented with recurrent relapses. Solid-phase enzyme immunoassay detected proinflammatory cytokines (interleukin-6, tumor necrosis factor-α), chemokines (interleukin-8, monocyte chemoattractant protein-1), growth factors (vascular endothelial growth factor, transforming growth factor-β1), and osteodestruction markers (osteoprogesterin, matrix metalloproteinase-8) in the blood serum and the extracted spinal disc tissue.
Results. We found that spinal disk destruction and chronic inflammation developed with both locally and generally elevating levels of proinflammatory cytokines/chemokines, growth factors, and matrix metalloproteinase 8.
Conclusion. The results emphasize the significance of local changes in the studied parameters to choose and plan personalized surgical treatment in patients with spinal disk herniation.
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##article.viewOnOriginalSite##About the authors
Vladimir A. Chekhonatskiy
Russian Medical Academy of Continuous Professional Education
Author for correspondence.
Email: fax-1@yandex.ru
ORCID iD: 0000-0001-6155-1154
postgraduate student, Department of neurosurgery
Russian Federation, MoscowOleg N. Dreval
Russian Medical Academy of Continuous Professional Education
Email: odreval@nsi.ru
ORCID iD: 0000-0002-8944-9837
D. Sci. (Med.), Professor, Head, Department of neurosurgery
Russian Federation, MoscowAleksei V. Kuznetsov
Russian Medical Academy of Continuous Professional Education
Email: akuznetsov@nsi.ru
ORCID iD: 0000-0002-9487-6008
Cand. Sci. (Med.), Associate Professor, Department of neurosurgery
Russian Federation, MoscowAndrey A. Chekhonatskiy
Saratov State Medical University named after V.I. Razumovsky
Email: fax-1@yandex.ru
ORCID iD: 0000-0003-3327-1483
D. Sci. (Med.), Head, Department of neurosurgery
Russian Federation, SaratovNatalya B. Zakharova
Saratov State Medical University named after V.I. Razumovsky
Email: lipidgormon@mail.ru
ORCID iD: 0000-0003-0289-3562
D. Sci. (Med.), Professor, Department of clinical laboratory diagnostics
Russian Federation, SaratovElena A. Grishina
Russian Medical Academy of Continuous Professional Education
Email: ncmu@almazovcentre.ru
ORCID iD: 0000-0002-5621-8266
D. Sci. (Med.), Professor, Director, Research Institute of Molecular and Personalized Medicine
Russian Federation, MoscowAleksandr V. Gorozhanin
S.P. Botkin City Clinical Hospital
Email: agorozhanin@list.ru
ORCID iD: 0000-0002-3593-7034
Cand. Sci. (Med.), Head, Neurosurgery department No. 19
Russian Federation, MoscowVera V. Volna
S.P. Botkin City Clinical Hospital
Email: neurosurgeon-sidorenko@mail.ru
neurosurgeon, Neurosurgery department No. 19
Russian Federation, MoscowReferences
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