We assessed the morphological changes induced by intraventricular haemorrhage (IVH) and investigated the effects of intraventricular fibrinolytic treatment following IVH. The experiment was performed in 30 Wistar rats. In first (control) group (15 rats) animals received intraventricular injection of 40 microl autologous blood with 10 microl normal saline. In second group (15 rats) 40 microl autologous blood with 10 microl t-PA recombinant tissue plasminogen activator (t-PA) was injected in ventricular of the animals. Morphological examination of the brains were carried out 2 days and 21 days following IVH. Marked losses of the ependymal covering of the ventricular walls, choroids plexus were founded in bouth groups. The results indicate that intraventricular administered t-PA significantly enhanced the lysis of intraventricular blood clots, but r-PA (in second group) promoted delayed periventricular white matter edema formation (more 21 days).
Morphological changes of the choroids plexus and ventricular walls of the cerebrum following experimental intraventricular haemorrhage
- Authors: Shirshov A.V.1, Gulevskaya T.S.1, Morgunov V.A.1, Kucheryanu V.G.2
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Affiliations:
- Research Center of Neurology, Russian Academy of Medical Sciences, Moscow
- Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 2, No 3 (2008)
- Pages: 25-29
- Section: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124395
- DOI: https://doi.org/10.17816/psaic398
- ID: 124395
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About the authors
A. V. Shirshov
Research Center of Neurology, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: platonova@neurology.ru
Russian Federation
T. S. Gulevskaya
Research Center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
V. A. Morgunov
Research Center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
V. G. Kucheryanu
Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
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