The comparative analysis of pathogenic mechanisms of ischemic stroke in patients with and without Patent Foramen Ovale (PFO) was performed. 101 patients with cryptogenic stroke and stroke of known etiology were examined. All patients underwent a diagnostic protocol including brain CT/MRI scan, haemostatic system testing, ECG, standard echocardiography, transthoracal echocardiography with bubble test and transcranial Doppler with bubble test; 51 patient underwent transesophageal echocardiography. PFO was found in half of the patients with ischemic stroke. However, the paradoxical cerebral embolism could not be considered as a main stroke risk factor in the studied cases: the mechanism of stroke in PFO was clarified with the same frequency, as in patients without PFO. So, in the presence of other competing risk factors of cerebral lesion, PFO does not play independent pathogenic role in the genesis of brain ischemia.
Pathogenic heterogenety of ischemic stroke and patent foramen ovale
- Authors: Suslina Z.A.1, Fonyakin A.V.1, Chechetkin A.O.1, Glebov M.V.1, Geraskina L.A.1, Nikitin Y.M.1, Kravchenko M.A.1
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Affiliations:
- Research center of Neurology, Russian Academy of Medical Sciences, Moscow
- Issue: Vol 2, No 3 (2008)
- Pages: 4-8
- Section: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124389
- DOI: https://doi.org/10.17816/psaic402
- ID: 124389
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About the authors
Z. A. Suslina
Research center of Neurology, Russian Academy of Medical Sciences, Moscow
Author for correspondence.
Email: platonova@neurology.ru
Russian Federation
A. V. Fonyakin
Research center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
A. O. Chechetkin
Research center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
M. V. Glebov
Research center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
L. A. Geraskina
Research center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
Yu. M. Nikitin
Research center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
M. A. Kravchenko
Research center of Neurology, Russian Academy of Medical Sciences, Moscow
Email: platonova@neurology.ru
Russian Federation
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