EEG features in patients with Parkinson's disease during directional perception of olfactory stimuli
- Authors: Kozhevnikov S.P.1, Ivanova I.L.2, Komissarova N.V.2, Shubina A.V.2, Vlasov M.A.1
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Affiliations:
- Udmurt State University
- Izhevsk State Medical Academy
- Issue: Vol 15, No 4 (2021)
- Pages: 27-35
- Section: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124084
- DOI: https://doi.org/10.54101/ACEN.2021.4.3
- ID: 124084
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Abstract
Introduction. Olfactory dysfunction is considered to be an early and relatively important marker of Parkinson's disease (PD). Olfactory studies using objective neurophysiological methods may become one of the diagnostic tests to identify individuals with a high risk of developing PD.
The aim of the study was to assess the spectral and topographic characteristics of bioelectrical brain activity in patients with PD during directional perception of olfactory stimuli.
Materials and methods. This study included 30 patients with PD (mean age was 66.5 ± 6.5 years). The control group consisted of 20 people without PD (mean age was 65.3 ± 8.5 years). Lavender oil, clove oil, camphor oil and β-mercaptoethanol solution (an aversive stimulus) were used for olfactory stimulation, while distilled water was used as a control test. The test subject sat with their eyes closed and inhaled the presented smell for 30 seconds, while an EEG recording was made during this time.
Study results. Olfactory stimulation in patients with PD showed increased synchronicity of the α3 rhythm in the right hemisphere, as well as the θ rhythm in the parieto-occipital regions of both hemispheres. These changes indicate significant activation of internal (endogenous) attention, increased overall, non-specific readiness potential, as well as the involvement of the limbic-reticular complex in olfactory perception. Olfactory perception in the control group was accompanied by reduction in the α1 rhythm amplitude in the parieto-occipital regions bilaterally, which may indicate moderate activation of external (exogenous) attention and the posterior attention system responsible for simple perception processes.
Conclusion. Increased α3 rhythm amplitude in the right hemisphere and increased θ rhythm amplitude, observed during directional olfactory perception, may indicate olfactory dysfunction and should be viewed as an additional indicator when establishing a diagnosis of Parkinson’s disease.
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##article.viewOnOriginalSite##About the authors
Sergey P. Kozhevnikov
Udmurt State University
Author for correspondence.
Email: ksp55@yandex.ru
ORCID iD: 0000-0003-4753-0474
Cand. Sci. (Biol.), Associate Professor, Department of physiology, cell biology and biotechnology, Institute of Natural Sciences
Russian Federation, IzhevskIrina L. Ivanova
Izhevsk State Medical Academy
Email: ksp55@yandex.ru
ORCID iD: 0000-0002-6530-3497
Cand. Sci. (Med.), Associate Professor, Department of neurology, neurosurgery and medical genetics
Russian Federation, IzhevskNatalia V. Komissarova
Izhevsk State Medical Academy
Email: ksp55@yandex.ru
ORCID iD: 0000-0002-1319-9616
Cand. Sci. (Med.), Head, Department of neurology, neurosurgery and medical genetics
Russian Federation, IzhevskAnastasia V. Shubina
Izhevsk State Medical Academy
Email: ksp55@yandex.ru
ORCID iD: 0000-0002-7750-7235
clinical resident, Department of neurology, neurosurgery and medical genetics
Russian Federation, IzhevskMatvey A. Vlasov
Udmurt State University
Email: ksp55@yandex.ru
ORCID iD: 0000-0002-9623-6805
student, Institute of Natural Sciences
Russian Federation, IzhevskReferences
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