Rare co-occurrence of multiple sclerosis and Parkinson's disease: a case report

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Abstract

A review of Russian and foreign medical literature, as well as the Web of Science, PubMed and Scopus databases, revealed 8 cases of multiple sclerosis and Parkinson's disease co-occurrence. Parkinson's disease is a chronic, progressive neurological disease caused by degeneration of dopaminergic neurons in the substantia nigra. Multiple sclerosis is a chronic demyelinating disease, in which a range of autoimmune-driven inflammatory and neurodegenerative processes lead to formation of numerous focal and diffuse lesions in the central nervous system, resulting in disability and a significant decrease in patient quality of life. The co-occurrence of these two neurodegenerative CNS disorders is rarely seen in clinical practice.

The authors describe a clinical case to demonstrate their approach to the diagnosis and management of this patient group.

About the authors

Ekaterina A. Ruina

Volga Research Medical University

Email: vadik.yulin@yandex.ru
ORCID iD: 0000-0003-4595-2614

Cand. Sci. (Med.), Associate Professor, Department of neurology, psychiatry and narcology

Russian Federation, Nizhny Novgorod

Ekaterina A. Aleksandrova

Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

Email: vadik.yulin@yandex.ru
ORCID iD: 0000-0001-5012-945X

Cand. Sci. (Med.), Associate Professor, neurologist, Cabinet of extrapyramidal disorders

Russian Federation, Nizhny Novgorod

Elena V. Parshina

Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashk

Email: vadik.yulin@yandex.ru
ORCID iD: 0000-0001-7033-053X

Cand. Sci. (Med.), Head, Neurological department

Russian Federation, Nizhny Novgorod

Danil N. Rodygin

Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

Email: vadik.yulin@yandex.ru
ORCID iD: 0000-0002-3191-4249

neurologist, Neurological department

Russian Federation, Nizhny Novgorod

Vadim S. Yulin

Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko

Author for correspondence.
Email: vadik.yulin@yandex.ru
ORCID iD: 0000-0003-3956-2986

neurologist, Neurological department

Russian Federation, Nizhny Novgorod

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2. Fig. 1. Brain MRI of patient S. — T2-weighted (A) and FLAIR sequences (B), 13.03.2019.

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3. Fig. 2. Cervical spine MRI of patient S. — STIR sequence, 13.03.2019.

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4. Fig. 3. Brain MRI of patient S. — T1-weighted and T2-weighted sequences, 10.01.2020.

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Copyright (c) 2022 Ruina E.A., Aleksandrova E.A., Parshina E.V., Rodygin D.N., Yulin V.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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