Biomarkers of fibroplastic changes in the kidney in unilateral ureteral obstruction
- Autores: Shormanov I.S.1, Zhigalov S.A.1, Solovyev A.S.1, Bazhina O.V.1, Shormanova N.S.1
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Afiliações:
- Yaroslavl State Medical University
- Edição: Volume 17, Nº 2 (2025)
- Páginas: 37-41
- Seção: Nephrourology
- URL: https://journals.rcsi.science/2075-3594/article/view/330403
- DOI: https://doi.org/10.18565/nephrology.2025.2.37-41
- ID: 330403
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Resumo
Objective. Evaluation of the dynamics of blood serum markers of fibroplastic transformation of the kidney in unilateral ureteral obstruction.
Material and methods. The study was approved by the local ethics committee of Yaroslavl State Medical University. A prospective comparative study was conducted, which included 33 patients with urolithiasis and unilateral ureteral obstruction caused by a stone less than 7 mm, and 15 healthy volunteers. The concentration of profibrotic cytokines TGF-β1 and CTGF was determined by ELISA. Diagnostics was performed using ultrasound and plain urography.
Results. In patients with ureteral obstruction, serum TGF-β1 (264±16.9 ng/ml) and CTGF (1141±33.1 ng/ml) concentrations at admission were significantly higher (p<0.001) than in the control group (TGF-β1 – 33±6.9 ng/ml, CTGF – 216.3±56.9 ng/ml). After 1 week, a sharp increase in TGF-β1 (18,239±556 ng/ml) and CTGF (45,765±123 ng/ml) levels was observed, indicating the development of severe fibrosis. After 1 month, blood cytokine concentrations decreased but remained above control values. Complete normalization of TGF-β1 (45±5.2 ng/ml) and CTGF (177±11.9 ng/ml) levels was observed only 2 months after obstruction elimination. In patients with prolonged obstruction (3–7 days), cytokine levels were significantly higher (p=0.03), indicating more pronounced fibrosis formation.
Conclusion. Unilateral ureteral obstruction leads to a significant increase in plasma TGF-β1 and CTGF levels, indicating the development of renal tissue fibrosis. The duration of obstruction affects the degree of fibrosis, emphasizing the need for early intervention and the promise of antifibrotic therapy.
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##article.viewOnOriginalSite##Sobre autores
Igor Shormanov
Yaroslavl State Medical University
Autor responsável pela correspondência
Email: i-s-shormanov@yandex.ru
ORCID ID: 0000-0002-2062-0421
Dr.Med. (Med.), Professor, Head of the Urology and Nephrology Department
Rússia, YaroslavlSergey Zhigalov
Yaroslavl State Medical University
Email: sergey.zhigalow@gmail.com
ORCID ID: 0000-0003-2464-572X
Cand.Sci. (Med.), Associate Professor, Urology and Nephrology Department
Rússia, YaroslavlAndrey Solovyev
Yaroslavl State Medical University
Email: a-s-soloviev89@yandex.ru
ORCID ID: 0000-0001-5612-3227
Cand.Sci. (Med.), Associate Professor at the Urology and Nephrology Department
Rússia, YaroslavlOlga Bazhina
Yaroslavl State Medical University
Email: mascot212@mail.ru
ORCID ID: 0009-0004-5741-261X
Cand.Sci. (Med.), Associate Professor at the Urology with Nephrology Department
Rússia, YaroslavlNatalia Shormanova
Yaroslavl State Medical University
Email: lady.schormanova@yandex.ru
Cand.Sci. (Med.), Associate Professor at the Department of Pathological Anatomy
Rússia, YaroslavlBibliografia
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